Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Mitchell H, Keylor"'
Autor:
David A. Candito, Vladimir Simov, Anmol Gulati, Solomon Kattar, Ryan W. Chau, Blair T. Lapointe, Joey L. Methot, Duane E. DeMong, Thomas H. Graham, Ravi Kurukulasuriya, Mitchell H. Keylor, Ling Tong, Gregori J. Morriello, John J. Acton, Barbara Pio, Weiguo Liu, Jack D. Scott, Michael J. Ardolino, Theodore A. Martinot, Matthew L. Maddess, Xin Yan, Hakan Gunaydin, Rachel L. Palte, Spencer E. McMinn, Lisa Nogle, Hongshi Yu, Ellen C. Minnihan, Charles A. Lesburg, Ping Liu, Jing Su, Laxminarayan G. Hegde, Lily Y. Moy, Janice D. Woodhouse, Robert Faltus, Tina Xiong, Paul Ciaccio, Jennifer A. Piesvaux, Karin M. Otte, Matthew E. Kennedy, David Jonathan Bennett, Erin F. DiMauro, Matthew J. Fell, Santhosh Neelamkavil, Harold B. Wood, Peter H. Fuller, J. Michael Ellis
Publikováno v:
Journal of Medicinal Chemistry. 65:16801-16817
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::365ba0e1a6a6d085b4344b637344b726
https://doi.org/10.1021/acs.jmedchem.2c01605
https://doi.org/10.1021/acs.jmedchem.2c01605
Autor:
David A, Candito, Vladimir, Simov, Anmol, Gulati, Solomon, Kattar, Ryan W, Chau, Blair T, Lapointe, Joey L, Methot, Duane E, DeMong, Thomas H, Graham, Ravi, Kurukulasuriya, Mitchell H, Keylor, Ling, Tong, Gregori J, Morriello, John J, Acton, Barbara, Pio, Weiguo, Liu, Jack D, Scott, Michael J, Ardolino, Theodore A, Martinot, Matthew L, Maddess, Xin, Yan, Hakan, Gunaydin, Rachel L, Palte, Spencer E, McMinn, Lisa, Nogle, Hongshi, Yu, Ellen C, Minnihan, Charles A, Lesburg, Ping, Liu, Jing, Su, Laxminarayan G, Hegde, Lily Y, Moy, Janice D, Woodhouse, Robert, Faltus, Tina, Xiong, Paul, Ciaccio, Jennifer A, Piesvaux, Karin M, Otte, Matthew E, Kennedy, David Jonathan, Bennett, Erin F, DiMauro, Matthew J, Fell, Santhosh, Neelamkavil, Harold B, Wood, Peter H, Fuller, J Michael, Ellis
Publikováno v:
Journal of medicinal chemistry. 65(24)
Inhibition of leucine-rich repeat kinase 2 (LRRK2) kinase activity represents a genetically supported, chemically tractable, and potentially disease-modifying mechanism to treat Parkinson's disease. Herein, we describe the optimization of a novel ser
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d1e71dbb505d333749f04ff7e2a07818
https://pubmed.ncbi.nlm.nih.gov/36475697
https://pubmed.ncbi.nlm.nih.gov/36475697
Autor:
Mitchell H. Keylor, Anmol Gulati, Solomon D. Kattar, Rebecca E. Johnson, Ryan W. Chau, Kaila A. Margrey, Michael J. Ardolino, Cayetana Zarate, Kelsey E. Poremba, Vladimir Simov, Gregori J. Morriello, John J. Acton, Barbara Pio, Xin Yan, Rachel L. Palte, Spencer E. McMinn, Lisa Nogle, Charles A. Lesburg, Donovon Adpressa, Shishi Lin, Santhosh Neelamkavil, Ping Liu, Jing Su, Laxminarayan G. Hegde, Janice D. Woodhouse, Robert Faltus, Tina Xiong, Paul J. Ciaccio, Jennifer Piesvaux, Karin M. Otte, Harold B. Wood, Matthew E. Kennedy, David Jonathan Bennett, Erin F. DiMauro, Matthew J. Fell, Peter H. Fuller
Publikováno v:
Journal of medicinal chemistry. 65(1)
The leucine-rich repeat kinase 2 (LRRK2) protein has been genetically and functionally linked to Parkinson's disease (PD), a disabling and progressive neurodegenerative disorder whose current therapies are limited in scope and efficacy. In this repor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6720c280fccf3e18653a864a196348ad
https://pubmed.ncbi.nlm.nih.gov/34967623
https://pubmed.ncbi.nlm.nih.gov/34967623
Autor:
Ethan J Strobel, Markus Griesser, Mitchell H. Keylor, Kevin J Romero, Corey R. J. Stephenson, Derek A. Pratt, Xu Zhu
Publikováno v:
J Am Chem Soc
The first total synthesis of the resveratrol tetramers vitisin A and vitisin D is reported. Electrochemical generation and selective dimerization of persistent radicals is followed by thermal isomerization of the symmetric C8b–C8c dimer to the C3c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64df51a1a41badf07d32bfc5e61c8a2c
https://europepmc.org/articles/PMC8162734/
https://europepmc.org/articles/PMC8162734/
Autor:
Ethan J Strobel, Kevin J Romero, Markus Griesser, Derek A. Pratt, Corey R. J. Stephenson, Mitchell H. Keylor, Xu Zhu
The total synthesis of oligomer natural products derived from resveratrol has been achieved through a putative biogenetic bond migration from a presumed common intermediate in a divergent biosynthetic pathway.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b34f94f53af11dad19d355543693b179
https://doi.org/10.26434/chemrxiv.10294826.v1
https://doi.org/10.26434/chemrxiv.10294826.v1
Autor:
YuXuan Lin, Shelby Allison, Mitchell H. Keylor, Derek A. Pratt, Bryan S. Matsuura, Bo Li, Corey R. J. Stephenson
Publikováno v:
Angewandte Chemie International Edition. 54:3754-3757
An efficient synthetic route to the resveratrol oligomers quadrangularin A and pallidol is reported. It features a scalable biomimetic oxidative dimerization that proceeds in excellent yield and with complete regioselectivity. A systematic evaluation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0b71ec448a954a9f5a9e92a822efd28
https://doi.org/10.1002/anie.201409773
https://doi.org/10.1002/anie.201409773
Publikováno v:
Journal of the American Chemical Society. 139(31)
A new catalyst system capable of selective chloride functionalization in the Pd-catalyzed amination of 3,2- and 5,2- Br/Cl-pyridines is reported. A reaction optimization strategy employing ligand parametrization led to the identification of 1,1′-bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80e70e6fe86e036c3666b341736671ab
https://pubmed.ncbi.nlm.nih.gov/28715180
https://pubmed.ncbi.nlm.nih.gov/28715180
Autor:
Ryan A. Harding, Mariia S. Kirillova, Jean-Philippe R. Chauvin, Derek A. Pratt, Bryan S. Matsuura, Mitchell H. Keylor, Oliver J. Fischer, Corey R. J. Stephenson, Xu Zhu, Markus Griesser
Catching a break in polyphenol synthesis Chemical synthesis is usually rather different from playing with a modeling kit. If two large fragments of a molecule are not properly oriented, it is not typically possible to break them apart, rotate one, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8512d2fedbdc407f147501dbe711bfe
https://europepmc.org/articles/PMC5310221/
https://europepmc.org/articles/PMC5310221/
Publikováno v:
Chemical Reviews
Since the dawn of the 20th century, the average life expectancy at birth has nearly doubled due to advances in science and medicine. As medical records grew more reliable, it became apparent that, while overall life span was increasing, there were si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fddda32ed88b1a964ed3a5c2dcf87c6d
https://pubmed.ncbi.nlm.nih.gov/25835567
https://pubmed.ncbi.nlm.nih.gov/25835567
Publikováno v:
ChemInform. 45
A photocatalytic method for thiol-ene click reactions as well as a methodology for the preparation of thiomorpholin-3-ones are described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b39562b67a60ffa046b57189d6aaa18
https://doi.org/10.1002/chin.201443050
https://doi.org/10.1002/chin.201443050