Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Mitchell G. Lawrence"'
Autor:
Zifeng Wang, Scott L. Townley, Songqi Zhang, Mingyu Liu, Muqing Li, Maryam Labaf, Susan Patalano, Kavita Venkataramani, Kellee R. Siegfried, Jill A. Macoska, Dong Han, Shuai Gao, Gail P. Risbridger, Renea A. Taylor, Mitchell G. Lawrence, Housheng Hansen He, Luke A. Selth, Changmeng Cai
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract FOXA family proteins act as pioneer factors by remodeling compact chromatin structures. FOXA1 is crucial for the chromatin binding of the androgen receptor (AR) in both normal prostate epithelial cells and the luminal subtype of prostate can
Externí odkaz:
https://doaj.org/article/948df13babe245438050b25ad66931fd
Autor:
Daisuke Obinata, Daigo Funakoshi, Kenichi Takayama, Makoto Hara, Birunthi Niranjan, Linda Teng, Mitchell G. Lawrence, Renea A. Taylor, Gail P. Risbridger, Yutaka Suzuki, Satoru Takahashi, Satoshi Inoue
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Androgen and androgen receptor (AR) targeted therapies are the main treatment for most prostate cancer (PC) patients. Although AR signaling inhibitors are effective, tumors can evade this treatment by transforming to an AR-negative PC via li
Externí odkaz:
https://doaj.org/article/d6c03cc267064f57ba8c32b937a95a5a
Autor:
Gail P. Risbridger, Ashlee K. Clark, Laura H. Porter, Roxanne Toivanen, Andrew Bakshi, Natalie L. Lister, David Pook, Carmel J. Pezaro, Shahneen Sandhu, Shivakumar Keerthikumar, Rosalia Quezada Urban, Melissa Papargiris, Jenna Kraska, Heather B. Madsen, Hong Wang, Michelle G. Richards, Birunthi Niranjan, Samantha O’Dea, Linda Teng, William Wheelahan, Zhuoer Li, Nicholas Choo, John F. Ouyang, Heather Thorne, Lisa Devereux, Rodney J. Hicks, Shomik Sengupta, Laurence Harewood, Mahesh Iddawala, Arun A. Azad, Jeremy Goad, Jeremy Grummet, John Kourambas, Edmond M. Kwan, Daniel Moon, Declan G. Murphy, John Pedersen, David Clouston, Sam Norden, Andrew Ryan, Luc Furic, David L. Goode, Mark Frydenberg, Mitchell G. Lawrence, Renea A. Taylor
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The prognosis of castration-resistant prostate cancers remains dismal, but accurate preclinical models can lead to effective therapies. Here the Melbourne Urological Research Alliance establish prostate cancer patient-derived xenografts, use the tumo
Externí odkaz:
https://doaj.org/article/72ce33db9321419ba5cb98782c40a1e1
Autor:
Daisuke Obinata, Mitchell G. Lawrence, Kenichi Takayama, Nicholas Choo, Gail P. Risbridger, Satoru Takahashi, Satoshi Inoue
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
The androgen receptor (AR) is the main therapeutic target in advanced prostate cancer, because it regulates the growth and progression of prostate cancer cells. Patients may undergo multiple lines of AR-directed treatments, including androgen-depriva
Externí odkaz:
https://doaj.org/article/720e286b5246441484ff9ecd57055955
Autor:
Renea A. Taylor, Michael Fraser, Julie Livingstone, Shadrielle Melijah G. Espiritu, Heather Thorne, Vincent Huang, Winnie Lo, Yu-Jia Shiah, Takafumi N. Yamaguchi, Ania Sliwinski, Sheri Horsburgh, Alice Meng, Lawrence E. Heisler, Nancy Yu, Fouad Yousif, Melissa Papargiris, Mitchell G. Lawrence, Lee Timms, Declan G. Murphy, Mark Frydenberg, Julia F. Hopkins, Damien Bolton, David Clouston, John D. McPherson, Theodorus van der Kwast, Paul C. Boutros, Gail P. Risbridger, Robert G. Bristow
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Men that carrierBRCA2germline mutations are at risk of developing prostate cancer. Here, the authors analyse the genomes of prostate cancer from these individuals and demonstrate increased genomic instability in comparison to sporadic prostate cancer
Externí odkaz:
https://doaj.org/article/8d920a8293a04405b9542b7f3b199b5c
Autor:
Linda K. H. Teng, Brooke A. Pereira, Shivakumar Keerthikumar, Cheng Huang, Birunthi Niranjan, Sophie N. Lee, Michelle Richards, Ralf B. Schittenhelm, Luc Furic, David L. Goode, Mitchell G. Lawrence, Renea A. Taylor, Stuart J. Ellem, Gail P. Risbridger, Natalie L. Lister
Publikováno v:
Cancers, Vol 13, Iss 6, p 1237 (2021)
Mast cells (MCs) are important cellular components of the tumor microenvironment and are significantly associated with poor patient outcomes in prostate cancer and other solid cancers. The promotion of tumor progression partly involves heterotypic in
Externí odkaz:
https://doaj.org/article/01e103df16a74ec79013e91e9a9c030d
Autor:
Rachel S Lee, Luxi Zhang, Adeline Berger, Mitchell G Lawrence, Jiangning Song, Birunthi Niranjan, Rebecca G Davies, Natalie L Lister, Shahneen K Sandhu, Mark A Rubin, Gail P Risbridger, Renea A Taylor, David S Rickman, Lisa G Horvath, Roger J Daly
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 21, Iss 4, Pp 389-400 (2019)
Approximately 50% of prostate cancers harbor the TMPRSS2:ERG fusion, resulting in elevated expression of the ERG transcription factor. Despite the identification of this subclass of prostate cancers, no personalized therapeutic strategies have achiev
Externí odkaz:
https://doaj.org/article/4a7b029a212c4c5ca3411e35327e4a0c
Autor:
Daryl Thompson, Nicholas Choo, Damien M. Bolton, Nathan Lawrentschuk, Gail P. Risbridger, Mitchell G. Lawrence, Renea A. Taylor
Publikováno v:
Current Opinion in Urology. 32:472-480
Many clinical trials are currently underway to target the epigenome of castration-resistant prostate cancer. In this review, we summarize the major epigenetic alterations that occur during prostate cancer progression, describe their biological conseq
Publikováno v:
Journal of Endocrinology. 257
There is longstanding interest in the role of androgens in the aetiology of prostate cancer, one of the most common malignancies worldwide. In this review, we reflect on the ways that knowledge of prostate development and hormone action have catalyse
Autor:
Luc Furic, Gail P. Risbridger, Renea A. Taylor, Kaylene J. Simpson, Ross D. Hannan, Richard B. Pearson, Elaine Sanij, David L. Goode, Andrew Bakshi, Jennii Luu, Susanne Ramm, Shahneen Sandhu, Carmel J. Pezaro, Jeremy P. Grummet, David Pook, Nicholas Choo, Laura H. Porter, Mitchell G. Lawrence
Supplementary Methods, Figures, and Tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::241fa416456af669f6859202417c09a5
https://doi.org/10.1158/1535-7163.22522815.v1
https://doi.org/10.1158/1535-7163.22522815.v1