Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Mitchell G Rezzonico"'
Autor:
Yuanyuan Wang, Tiffany Wu, Ming-Chi Tsai, Mitchell G Rezzonico, Alyaa M Abdel-Haleem, Luke Xie, Vineela D Gandham, Hai Ngu, Kimberly Stark, Caspar Glock, Daqi Xu, Oded Foreman, Brad A Friedman, Morgan Sheng, Jesse E Hanson
Publikováno v:
eLife, Vol 12 (2023)
Tumor progression locus 2 (TPL2) (MAP3K8) is a central signaling node in the inflammatory response of peripheral immune cells. We find that TPL2 kinase activity modulates microglial cytokine release and is required for microglia-mediated neuron death
Externí odkaz:
https://doaj.org/article/0de297db33c643f2ae2e401f38b89b3b
Autor:
Borislav Dejanovic, Tiffany Wu, Ming-Chi Tsai, David Graykowski, Vineela D. Gandham, Christopher M. Rose, Corey E. Bakalarski, Hai Ngu, Yuanyuan Wang, Shristi Pandey, Mitchell G. Rezzonico, Brad A. Friedman, Rose Edmonds, Ann De Mazière, Raphael Rakosi-Schmidt, Tarjinder Singh, Judith Klumperman, Oded Foreman, Michael C. Chang, Luke Xie, Morgan Sheng, Jesse E. Hanson
Publikováno v:
Nature Aging. 2:837-850
Microglia and complement can mediate neurodegeneration in Alzheimer’s disease (AD). By integrative multi-omics analysis, here we show that astrocytic and microglial proteins are increased in TauP301S synapse fractions with age and in a C1q-dependen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3123df57638f9af969ca987e8610231
https://doi.org/10.1038/s43587-022-00281-1
https://doi.org/10.1038/s43587-022-00281-1
Autor:
Yuanyuan Wang, Tiffany Wu, Ming-Chi Tsai, Mitchell G Rezzonico, Alyaa M Abdel-Haleem, Luke Xie, Vineela D Gandham, Hai Ngu, Kimberly Stark, Caspar Glock, Daqi Xu, Oded Foreman, Brad A Friedman, Morgan Sheng, Jesse E Hanson
TPL2 (MAP3K8) is a central signaling node in the inflammatory response of peripheral immune cells. We find that TPL2 kinase activity modulates microglial cytokine release and is required for microglia-mediated neuron deathin vitro. In acutein vivoneu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7fc4ffd68bf6c136e87a0857d07f9a45
https://doi.org/10.1101/2022.10.13.512193
https://doi.org/10.1101/2022.10.13.512193
Autor:
Shristi Pandey, Kimberle Shen, Seung-Hye Lee, Yun-An A. Shen, Yuanyuan Wang, Marcos Otero-García, Natalya Kotova, Stephen T. Vito, Benjamin I. Laufer, Dwight F. Newton, Mitchell G. Rezzonico, Jesse E. Hanson, Joshua S. Kaminker, Christopher J. Bohlen, Tracy J. Yuen, Brad A. Friedman
Publikováno v:
Cell Reports. 40:111189
Oligodendrocyte dysfunction has been implicated in the pathogenesis of neurodegenerative diseases, so understanding oligodendrocyte activation states would shed light on disease processes. We identify three distinct activation states of oligodendrocy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d468c3ee18ff004b00fa74d78b995d6
https://doi.org/10.1016/j.celrep.2022.111189
https://doi.org/10.1016/j.celrep.2022.111189
Autor:
Seung-Hye Lee, Mitchell G. Rezzonico, Brad A. Friedman, Melanie H. Huntley, William J. Meilandt, Shristi Pandey, Ying-Jiun J. Chen, Amy Easton, Zora Modrusan, David V. Hansen, Morgan Sheng, Christopher J. Bohlen
Publikováno v:
Cell Reports. 37:110158
Non-neuronal responses in neurodegenerative disease have received increasing attention as important contributors to disease pathogenesis and progression. Here we utilize single-cell RNA sequencing to broadly profile 13 cell types in three different m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9bf97ad65dcc8fce051d9e2fc13e321
https://doi.org/10.1016/j.celrep.2021.110158
https://doi.org/10.1016/j.celrep.2021.110158
Autor:
William J. Meilandt, Oded Foreman, Luke Xie, Christopher J. Bohlen, Brad A. Friedman, Amy Easton, Hai Ngu, David V. Hansen, Vineela D. Gandham, Richard A.D. Carano, Guita Lalehzadeh, Mitchell G. Rezzonico, Seung-Hye Lee, Kimberly L. Stark, Jose Imperio, Melanie A. Huntley, Kai H. Barck, Morgan Sheng
Publikováno v:
Neuron. 109:1283-1301.e6
Loss-of-function TREM2 mutations strongly increase Alzheimer's disease (AD) risk. Trem2 deletion has revealed protective Trem2 functions in preclinical models of β-amyloidosis, a prominent feature of pre-diagnosis AD stages. How TREM2 influences lat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ec2c8a3c5d683db273bd161547979e2
https://doi.org/10.1016/j.neuron.2021.02.010
https://doi.org/10.1016/j.neuron.2021.02.010