Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Mitchell D. Green"'
Autor:
R. Thomas Williamson, Edward C. Sherer, Mitchell D. Green, Christopher J. Welch, Erik L. Regalado, Leo A. Joyce, Derek W. Hendersonl
Publikováno v:
Chirality. 26:95-101
The absolute configuration of several hydroxywarfarin isomers was assigned using a comparison of elution order on chiral stationary phases, optical rotation, and circular dichroism (CD) spectra, with confirmation of assignments made by comparison bet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c019545566e55d0f29442937a48ed833
https://doi.org/10.1002/chir.22274
https://doi.org/10.1002/chir.22274
Autor:
Kelly M. Treonze, Russell B. Lingham, Richard A. Mumford, Kenneth Alves, Benito Munoz, Weichao Chen, Joyce P. James, Jasmine Zunic, Nicholas D. Smith, Thomas S. Reger, Bowei Wang, Michael F. Gardner, Nicholas Stock, Mitchell D. Green, Qian Si
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:1173-1176
A variety of N-linked tertiary amines and heteroarylamines were examined at the 4-position of sulfonylated proline dipeptides in order to improve VLA-4 receptor off-rates and overcome the issue of CYP3A4 time-dependent inhibition of ester prodrugs. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::418233da95288470cb2c8fbb4c8b2413
https://doi.org/10.1016/j.bmcl.2009.12.009
https://doi.org/10.1016/j.bmcl.2009.12.009
Publikováno v:
Life Sciences. 75:947-953
Characterization of new chemical entities for their potential to produce drug-drug interactions is an important aspect of early drug discovery screening. In the present study, the potential for three metabotropic glutamate receptor antagonists to int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ed5e5d67346bd724604243fb3e9032b
https://doi.org/10.1016/j.lfs.2004.02.009
https://doi.org/10.1016/j.lfs.2004.02.009
Publikováno v:
Journal of separation science. 37(9-10)
In this study, we investigate the separation of a variety of mixtures of drugs, metabolites, and related analogs including representatives of the carbamazepine, methylated xanthine, steroid hormone, nicotine, and morphine families using several autom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::27864e5670cf61a6d862fa412abcbf05
https://pubmed.ncbi.nlm.nih.gov/24596023
https://pubmed.ncbi.nlm.nih.gov/24596023
Publikováno v:
Molecular Pharmacology. 59:1464-1469
The UDP-glucuronosyltransferase UGT2B7 is an important human UGT isoform that catalyzes the conjugation of many endogenous and exogenous compounds, among them opioids, resulting in the formation of D-glucuronides. The binding site of the aglycone is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1ae66d4b7683018401418b130a935b4
https://doi.org/10.1124/mol.59.6.1464
https://doi.org/10.1124/mol.59.6.1464
Autor:
Éric Lévesque, Thomas R. Tephly, Dean W. Hum, Alain Bélanger, Mitchell D. Green, Martin Beaulieu
Publikováno v:
Pharmacogenetics. 7:317-325
Genetic polymorphisms occur in many of the drug metabolizing enzymes. However, the effect of polymorphisms in the genes encoding phase II drug metabolizing UDP-glucuronosyltransferases is still undescribed, despite the many reported cases of variatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1591a6277be9391517a5307ed29dcc8
https://doi.org/10.1097/00008571-199708000-00007
https://doi.org/10.1097/00008571-199708000-00007
Autor:
Catherine Abbadie, Vivien A. Warren, Xiaohua Li, James B Herrington, Gregory J. Kaczorowski, Shruti Mistry, Feng Ye, Andrew M. Swensen, Prasun K. Chakravarty, Rodolfo Haedo, Kathryn A. Lyons, Owen B. McManus, Randal M. Bugianesi, Mitchell D. Green, Shao Pengcheng Patrick, Maria L. Garcia, Shu-Yu Sun, McHardy M. Smith, Erin McGowan, Nina Jochnowitz, Joseph L. Duffy, Ge Dai
We report the investigation of sulfonamide-derived Cav2.2 inhibitors to address drug-metabolism liabilities with this lead class of analgesics. Modification of the benzamide substituent provided improvements in both potency and selectivity. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a14af3d556993551af77251b7d66937
https://europepmc.org/articles/PMC4027232/
https://europepmc.org/articles/PMC4027232/
Autor:
Erik L, Regalado, Edward C, Sherer, Mitchell D, Green, Derek W, Hendersonl, R, Thomas Williamson, Leo A, Joyce, Christopher J, Welch
Publikováno v:
Chirality. 26(2)
The absolute configuration of several hydroxywarfarin isomers was assigned using a comparison of elution order on chiral stationary phases, optical rotation, and circular dichroism (CD) spectra, with confirmation of assignments made by comparison bet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::99c139e2181b88b38b3384333325abf4
https://pubmed.ncbi.nlm.nih.gov/24339228
https://pubmed.ncbi.nlm.nih.gov/24339228
Autor:
Grace Chan, Cheri M Maciolek, Thomayant Prueksaritanont, Xiaoyan Chu, Yuhsin Kuo, Mitchell D. Green, Xiaoxin Cai, Yuexia Liang, Anima Ghosal, Donghui Cui, Jairam Palamanda, Cuyue Tang, Raymond Evers
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 41(3)
The inhibitory effect of boceprevir (BOC), an inhibitor of hepatitis C virus nonstructural protein 3 protease was evaluated in vitro against a panel of drug-metabolizing enzymes and transporters. BOC, a known substrate for cytochrome P450 (P450) CYP3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::067772cc5431f630bae1a7c620c493eb
https://pubmed.ncbi.nlm.nih.gov/23293300
https://pubmed.ncbi.nlm.nih.gov/23293300
Autor:
Gladys R. Rios, Ida S. Owens, Mitchell D. Green, Birgit L. Coffman, Warren P. Bishop, Thomas R. Tephly, Christopher D. King
Publikováno v:
Archives of Biochemistry and Biophysics. 332:92-100
Rat and human UDP-glucuronosyltransferase (UGT)1.1 share >70% identity in their deduced primary amino acid sequences. We have previously shown that rat UGT1.1, stably expressed in human embryonic kidney 293 cells, catalyzes the glucuronidation of bil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::414888d236ada24a7a501882fc54ff2f
https://doi.org/10.1006/abbi.1996.0320
https://doi.org/10.1006/abbi.1996.0320