Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Mitchell D. Green"'
Autor:
R. Thomas Williamson, Mitchell D. Green, Yong Liu, Wolfgang Bermel, Rosemary Marques, Tony Pereira, Roy Helmy, Gary E. Martin
Publikováno v:
Tetrahedron Letters. 55:5450-5453
Difficulties in isolating samples from complex biological matrices and sensitivity limitations have long stymied the utilization of heteronuclear 2D NMR for the characterization of drug metabolites. Small diameter cryogenic NMR probes have largely am
Publikováno v:
Journal of Separation Science. 37:1094-1102
In this study, we investigate the separation of a variety of mixtures of drugs, metabolites, and related analogs including representatives of the carbamazepine, methylated xanthine, steroid hormone, nicotine, and morphine families using several autom
Autor:
R. Thomas Williamson, Edward C. Sherer, Mitchell D. Green, Christopher J. Welch, Erik L. Regalado, Leo A. Joyce, Derek W. Hendersonl
Publikováno v:
Chirality. 26:95-101
The absolute configuration of several hydroxywarfarin isomers was assigned using a comparison of elution order on chiral stationary phases, optical rotation, and circular dichroism (CD) spectra, with confirmation of assignments made by comparison bet
Autor:
Kelly M. Treonze, Russell B. Lingham, Richard A. Mumford, Kenneth Alves, Benito Munoz, Weichao Chen, Joyce P. James, Jasmine Zunic, Nicholas D. Smith, Thomas S. Reger, Bowei Wang, Michael F. Gardner, Nicholas Stock, Mitchell D. Green, Qian Si
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:1173-1176
A variety of N-linked tertiary amines and heteroarylamines were examined at the 4-position of sulfonylated proline dipeptides in order to improve VLA-4 receptor off-rates and overcome the issue of CYP3A4 time-dependent inhibition of ester prodrugs. A
Publikováno v:
Life Sciences. 75:947-953
Characterization of new chemical entities for their potential to produce drug-drug interactions is an important aspect of early drug discovery screening. In the present study, the potential for three metabotropic glutamate receptor antagonists to int
Publikováno v:
Journal of separation science. 37(9-10)
In this study, we investigate the separation of a variety of mixtures of drugs, metabolites, and related analogs including representatives of the carbamazepine, methylated xanthine, steroid hormone, nicotine, and morphine families using several autom
Publikováno v:
Molecular Pharmacology. 59:1464-1469
The UDP-glucuronosyltransferase UGT2B7 is an important human UGT isoform that catalyzes the conjugation of many endogenous and exogenous compounds, among them opioids, resulting in the formation of D-glucuronides. The binding site of the aglycone is
Autor:
Éric Lévesque, Thomas R. Tephly, Dean W. Hum, Alain Bélanger, Mitchell D. Green, Martin Beaulieu
Publikováno v:
Pharmacogenetics. 7:317-325
Genetic polymorphisms occur in many of the drug metabolizing enzymes. However, the effect of polymorphisms in the genes encoding phase II drug metabolizing UDP-glucuronosyltransferases is still undescribed, despite the many reported cases of variatio
Autor:
Catherine Abbadie, Vivien A. Warren, Xiaohua Li, James B Herrington, Gregory J. Kaczorowski, Shruti Mistry, Feng Ye, Andrew M. Swensen, Prasun K. Chakravarty, Rodolfo Haedo, Kathryn A. Lyons, Owen B. McManus, Randal M. Bugianesi, Mitchell D. Green, Shao Pengcheng Patrick, Maria L. Garcia, Shu-Yu Sun, McHardy M. Smith, Erin McGowan, Nina Jochnowitz, Joseph L. Duffy, Ge Dai
We report the investigation of sulfonamide-derived Cav2.2 inhibitors to address drug-metabolism liabilities with this lead class of analgesics. Modification of the benzamide substituent provided improvements in both potency and selectivity. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a14af3d556993551af77251b7d66937
https://europepmc.org/articles/PMC4027232/
https://europepmc.org/articles/PMC4027232/
Autor:
Erik L, Regalado, Edward C, Sherer, Mitchell D, Green, Derek W, Hendersonl, R, Thomas Williamson, Leo A, Joyce, Christopher J, Welch
Publikováno v:
Chirality. 26(2)
The absolute configuration of several hydroxywarfarin isomers was assigned using a comparison of elution order on chiral stationary phases, optical rotation, and circular dichroism (CD) spectra, with confirmation of assignments made by comparison bet