Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Mitchell Brigell"'
Autor:
Roomasa Channa, MD, Risa M. Wolf, MD, Rafael Simo, MD, PhD, Mitchell Brigell, PhD, Patrice Fort, PhD, Christine Curcio, PhD, Stephanie Lynch, MD, Frank Verbraak, MD, PhD, Michael D. Abramoff, MD, PhD, Michael D. Abramoff, Roomasa Channa, Risa M. Wolf, Rafael Simo, Mitch Brigell, Patrice Fort, Christine Curcio, Stephanie Lynch, Frank Verbraak, Thomas W. Gardner
Publikováno v:
Ophthalmology Science, Vol 4, Iss 3, Pp 100420- (2024)
Topic: The goal of this review was to summarize the current level of evidence on biomarkers to quantify diabetic retinal neurodegeneration (DRN) and diabetic macular edema (DME). Clinical relevance: With advances in retinal diagnostics, we have more
Externí odkaz:
https://doaj.org/article/96ef4c0a4b904c46ab1afcd1b8121189
Autor:
Jay Pepose, Mitchell Brigell, Eliot Lazar, Curtis Heisel, Jonah Yousif, Kavon Rahmani, Ajay Kolli, Min Hwang, Cara Mitrano, Audrey Lazar, Konstantinos Charizanis, Mina Sooch, Marguerite McDonald
Publikováno v:
BMC Ophthalmology, Vol 22, Iss 1, Pp 1-11 (2022)
Abstract Purpose Dim light vision disturbances (DLD) comprise a wide range of symptoms affecting the quality of vision at low illumination including glare, halos, and starbursts. This exploratory study investigated 1.0% phentolamine mesylate ophthalm
Externí odkaz:
https://doaj.org/article/ae48f09373974398b5963ac579059bf2
Autor:
Eric M. Moult, Emily S. Levine, James G. Fujimoto, Nadia K Waheed, Eugenia Custo Greig, Frank Cao, Kevin G. Peters, Mitchell Brigell
Publikováno v:
American Journal of Ophthalmology. 219:66-76
Purpose To identify optical coherence tomography angiography (OCTA) derived vessel metrics of the macula and optic nerve head (ONH) that predict diabetic retinopathy (DR) disease progression. Design Secondary analysis of clinical trial data Methods T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::859d6cba8c7d461b36acf09e8684dfbe
https://doi.org/10.1016/j.ajo.2020.06.009
https://doi.org/10.1016/j.ajo.2020.06.009
Publikováno v:
Translational Vision Science & Technology
Purpose To evaluate the ocular hypotensive efficacy and safety of razuprotafib, a novel Tie2 activator, when used as an adjunct to latanoprost in patients with open-angle glaucoma (OAG) or ocular hypertension (OHT). Methods Subjects with OAG or OHT a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bbc184d7d9ef493612309cb10818cad
https://pubmed.ncbi.nlm.nih.gov/34989803
https://pubmed.ncbi.nlm.nih.gov/34989803
Autor:
Heather Schmitt, Astrid F. Nottebaum, Ute Ipe, Mitchell Brigell, Sarthak Mishra, Barbara Withers, Dietmar Vestweber, Brandi Soldo, Iris Navarro, Steve Pakola, W. Daniel Stamer, Kevin G. Peters, Guorong Li, Maria Gomez-Caraballo
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose Tyrosine kinase with immunoglobulin-like and EGF-like domains 2 (Tie2) activation in Schlemm's canal (SC) endothelium is required for the maintenance of IOP, making the angiopoietin/Tie2 pathway a target for new and potentially disease modify
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a084add86a0a7fd8c00ae9a18e8a3a68
https://pubmed.ncbi.nlm.nih.gov/33315051
https://pubmed.ncbi.nlm.nih.gov/33315051
Publikováno v:
Documenta ophthalmologica. Advances in ophthalmology. 140(1)
The International Society for the Clinical Electrophysiology of Vision (ISCEV) standard for full-field electroretinography (ERG) describes a minimum set of tests, but encourages the use of additional protocols for clinical ERG testing. This extended
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46924ec14fbf43f292759163009c4bf6
https://pubmed.ncbi.nlm.nih.gov/31902035
https://pubmed.ncbi.nlm.nih.gov/31902035
OR14-6 The Role of the Angiopoietin-Tie2 Pathway in Microvascular Complications of Diabetes Mellitus
Publikováno v:
Journal of the Endocrine Society
INTRODUCTION: The Tie2 pathway is a key regulator of vascular stability. Deactivation of this pathway, caused by hyperglycemia or ischemia, results in pathological vascular inflammation, permeability and neovascularization. AKB-9778 is a small molecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c62fae75b0f48161c22d60fa0126359b
https://doi.org/10.1210/js.2019-or14-6
https://doi.org/10.1210/js.2019-or14-6
Autor:
C. Stephen Foster, Steven Yeh, Mitchell Brigell, Cynthia L. Grosskreutz, Erik Letko, Uwe Pleyer
Publikováno v:
Ophthalmology. 122:939-948
Purpose Secukinumab, a fully human anti–interleukin-17A monoclonal antibody, exhibited promising activity in a proof-of-concept study when administered in intravenous (IV) doses to patients with active, chronic, noninfectious uveitis. This study co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7b5e5ab655b16cd3938e20b12757f81
https://doi.org/10.1016/j.ophtha.2014.12.033
https://doi.org/10.1016/j.ophtha.2014.12.033
Autor:
David A. Quillen, Mitchell Brigell, Gregory R. Jackson, Laura E. Walter, Ingrid U. Scott, Mark E. Clark
Publikováno v:
Optometry and Vision Science. 91:925-931
Purpose A sensitive endpoint is required for clinical trials evaluating preventative therapies for early age-related macular degeneration (AMD). Dark adaptation (DA) is a sensitive marker of AMD and has been proposed as a potential endpoint. This stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::933e08b7a2b2901792803e7f8c237a1f
https://doi.org/10.1097/opx.0000000000000247
https://doi.org/10.1097/opx.0000000000000247
Autor:
Michael Bach, Mitchell Brigell, Daphne L. McCulloch, Ruth Hamilton, Radouil Tzekov, Michael F. Marmor, Graham E. Holder
Publikováno v:
Documenta Ophthalmologica. 131:81-83
There is an error in Table 1 of the recently published ISCEV Standard for full-field clinical electroretinography (2015 update) [1]. Users of this standard should note that the filter settings for dark-adapted oscillatory potentials (OPs), as correct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb4f27c9a7539e998fc3701650c141c4
https://doi.org/10.1007/s10633-015-9504-z
https://doi.org/10.1007/s10633-015-9504-z