Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Mitchell A. Hamman"'
Autor:
Stephen D. Hall, Srikar R. Malireddy, Raj Vuppalanchi, Mitchell A. Hamman, Sara K. Quinney, Naga Chalasani, J. Christopher Gorski
Publikováno v:
European Journal of Clinical Pharmacology. 69:439-448
To determine the extent and time-course of hepatic and intestinal cytochrome P450 3A (CYP3A) inactivation due to the mechanism-based inhibitor clarithromycin.Intestinal and hepatic CYP3A inhibition was examined in 12 healthy volunteers following the
Autor:
Raj Vuppalanchi, Paul Y. Kwo, Naga Chalasani, Vijay Laxmi Misra, Charles J. Kahi, Mitchell A. Hamman, David R. Jones
Publikováno v:
Alimentary Pharmacology & Therapeutics. 32:1044-1050
Aliment Pharmacol Ther 2010; 32: 1044–1050 Summary Background Resistance to loop diuretics is common in patients with ascites. Diminished glomerular filtration rate (GFR) is thought to mediate resistance to loop diuretics. Midodrine, a commonly use
Autor:
Stephen D. Hall, Mitchell A. Hamman, Narjis A. Zaheer, Zaiqi Wang, G. L. Lemma, J. Christopher Gorski
Publikováno v:
Clinical Pharmacology & Therapeutics. 79:218-230
Background Verapamil has the capability to inhibit and induce cytochrome P450 (CYP) 3A and P-glycoprotein (P-gp), but the relative extent and time course of these events in vivo are unclear. The effect of verapamil on CYP3A and P-gp activity was dete
Autor:
Amar G. Pinto, John C. Horlander, Ali Asghar, Stephen D. Hall, Mitchell A. Hamman, Dhanashri Kolwankar, Naga Chalasani
Publikováno v:
British Journal of Clinical Pharmacology. 59:440-446
Aims To determine the effect of diltiazem on intestinal CYP3A activity and protein and mRNA expression in vivo in healthy subjects. Methods Intestinal biopsies were obtained from ten healthy controls and from ten healthy subjects after receiving dilt
Autor:
Stephen D. Hall, A. Q. Adigun, Nina Vasavada, Shiew-Mei Huang, J. Christopher Gorski, Zaiqi Wang, Mitchell A. Hamman, J. Hilligoss, Margaret Miller
Publikováno v:
Clinical Pharmacology & Therapeutics. 74:525-535
The popular herbal remedy St John's wort is an inducer of cytochrome P450 (CYP) 3A enzymes and may reduce the efficacy of oral contraceptives. Therefore we evaluated the effect of St John's wort on the disposition and efficacy of Ortho-Novum 1/35 (Or
Autor:
J. Christopher Gorski, Barbara Haehner‐Daniels, Mitchell A. Hamman, Walter T. Ambrosius, Suda Vannaprasaht, Stephen D. Hall, Melissa A. Bruce
Publikováno v:
Clinical Pharmacology & Therapeutics. 74:275-287
Background The relative susceptibility of intestinal and hepatic cytochrome P450 (CYP) 3A to induction by rifampin (INN, rifampicin), as a function of age and sex, was investigated with the CYP3A substrate midazolam. Methods Fourteen young women (mea
Autor:
Steven A. Wrighton, Varon E. Cantrell, Barbara J. Ring, James A. Eckstein, J. Andrew Williams, Stephen D. Hall, Mitchell A. Hamman, David R. Jones, Kenneth J. Ruterbories
Publikováno v:
Drug Metabolism and Disposition. 30:883-891
The human cytochromes P450 (P450) CYP3A contribute to the biotransformation of 50% of oxidatively metabolized drugs. The predominant hepatic form is CYP3A4, but recent evidence indicates that CYP3A5 contributes more significantly to the total liver C
Autor:
Mitchell A. Hamman, J. Christopher Gorski, Stephen D. Hall, Zaiqi Wang, Shiew-Mei Huang, Lawrence J. Lesko
Publikováno v:
Clinical Pharmacology & Therapeutics. 70:305-310
Background St John's wort(Hypericum perforatum) is a popular over-the-counter dietary supplement and herbal remedy that has been implicated in drug interactions with substrates of several cytochrome P450 (CYP) isozymes. The effect of St John's wort o
Autor:
Steven A. Wrighton, Barbara D. Haehner‐Daniels, Stephen D. Hall, Allan E. Rettie, Mitchell A. Hamman
Publikováno v:
Biochemical Pharmacology. 60:7-17
The stereoselective sulfoxidation of the pharmacologically active metabolite of sulindac, sulindac sulfide, was characterized in human liver, kidney, and cDNA-expressed enzymes. Kinetic parameter estimates (pH = 7.4) for sulindac sulfoxide formation
Publikováno v:
Xenobiotica. 29:931-944
1. To aid in the prediction of drug interactions with alprazolam, the human CYP involved in the 1'- and 4-hydroxylation of alprazolam were characterized using human liver microsomes, expressed enzymes and selective chemical inhibitors. 2. The formati