Zobrazeno 1 - 10
of 868
pro vyhledávání: '"Mitchell A. Cohen"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Cybermedical systems that regulate patient clotting in real time with personalized blood product delivery will improve treatment outcomes. These systems will harness popular viscoelastic assays of clot strength such as thromboelastography (T
Externí odkaz:
https://doaj.org/article/a4fedfeb77ad443c98cc3d905c287de1
Autor:
Akshay Pratap, Andrea Qualman, Hedlund Garrett, Lindsey Westbrook, Erlinda The, Sanchayita Mitra, Mila Cordero, Kenneth Meza Monge, Juan- Pablo Idrovo, Argudit Chauhan, Linling Cheng, Mitchell Jay Cohen, Benedetto Mungo, Sachin Wani, Robert Alexander Meguid, Martin D McCarter, Xianzhong Meng
Publikováno v:
Molecular & Cellular Oncology, Vol 10, Iss 1 (2023)
Poorly differentiated esophageal adenocarcinoma (PDEAC) has a dismal prognosis. Glypican-1(GPC-1) is known to be upregulated in several cancer types in contrast to healthy tissues, rendering it as a biomarker. Nevertheless, the potential therapeutic
Externí odkaz:
https://doaj.org/article/9b512504642c4c6e84d762da96a2d019
Publikováno v:
npj Systems Biology and Applications, Vol 7, Iss 1, Pp 1-17 (2021)
Abstract Current trauma-induced coagulopathy resuscitation protocols use slow laboratory measurements, rules-of-thumb, and clinician gestalt to administer large volumes of uncharacterized, non-tailored blood products. These one-size-fits-all treatmen
Externí odkaz:
https://doaj.org/article/5e7c57f3f56d4bd48f0aa293fdb0d4f9
Autor:
Alexis L Cralley, Margot DeBot, Jamie Hadley, Fredric Pieracci, Barry K Platnick, Eric Campion, Ernest E Moore, Mitchell J Cohen, Charles J Fox, Ryan A Lawless
Publikováno v:
Journal of Endovascular Resuscitation and Trauma Management, Vol 6, Iss 3 (2023)
Background: We hypothesized that emergent placement of 7 French (Fr) common femoral artery (CFA) sheaths during trauma resuscitation for potential resuscitative endovascular balloon occlusion of the aorta (REBOA) carries a low complication rate. Met
Externí odkaz:
https://doaj.org/article/ce883ee69c01480b90d992501d5693e6
Autor:
Paul Vulliamy, Lucy Z. Kornblith, Matthew E. Kutcher, Mitchell J. Cohen, Karim Brohi, Matthew D. Neal
Publikováno v:
Platelets, Vol 32, Iss 3, Pp 295-304 (2021)
Platelets are damage sentinels of the intravascular compartment, initiating and coordinating the primary response to tissue injury. Severe trauma and hemorrhage induce profound alterations in platelet behavior. During the acute post-injury phase, pla
Externí odkaz:
https://doaj.org/article/7c67f68c99cc4addac9700161caa9268
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-13 (2021)
Abstract Background Trauma-induced coagulopathy (TIC) is a disorder that occurs in one-third of severely injured trauma patients, manifesting as increased bleeding and a 4X risk of mortality. Understanding the mechanisms driving TIC, clinical risk fa
Externí odkaz:
https://doaj.org/article/40725b36b14d4f2399ceffa32d3426f8
Autor:
Hunter B. Moore, MD, PhD, Matthew D. Neal, MD, Marnie Bertolet, PhD, Brian A. Joughin, PhD, Michael B. Yaffe, MD, PhD, Christopher D. Barrett, MD, Molly A. Bird, BS, Russell P. Tracy, PhD, Ernest E Moore, MD, Jason L. Sperry, MD, Brian S. Zuckerbraun, MD, Myung S. Park, MD, Mitchell J. Cohen, MD, Stephen R. Wisniewski, PhD, James H. Morrissey, PhD, TACTIC Investigators
Publikováno v:
Annals of Surgery Open, Vol 3, Iss 2, p e167 (2022)
Objective:. Trauma-induced coagulopathy (TIC) is provoked by multiple mechanisms and is perceived to be one driver of massive transfusions (MT). Single laboratory values using prothrombin time (INR) or thrombelastography (TEG) are used to clinically
Externí odkaz:
https://doaj.org/article/99cb90e1cb8743f7a15129fd3f2eac4c
Autor:
Preston Stafford, Sanchayita Mitra, Margot Debot, Patrick Lutz, Arthur Stem, Jamie Hadley, Patrick Hom, Terry R Schaid, Mitchell J Cohen
Publikováno v:
PLoS ONE, Vol 17, Iss 7, p e0270817 (2022)
Blood Brain Barrier (BBB) breakdown is a secondary form of brain injury which has yet to be fully elucidated mechanistically. Existing research suggests that breakdown of tight junction proteins between endothelial cells is a primary driver of increa
Externí odkaz:
https://doaj.org/article/1c1eb1f476fb406195be3bf4c3749620
Autor:
Wil Lieberman-Cribbin, Stephanie Tuminello, Christina Gillezeau, Maaike van Gerwen, Rachel Brody, David J. Mulholland, Lori Horton, Maureen Sisco, Colette Prophete, Judith Zelikoff, Hyun-Wook Lee, Sung-Hyun Park, Lung-Chi Chen, Mitchell D. Cohen, Emanuela Taioli
Publikováno v:
Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-8 (2019)
Abstract World Trade Center (WTC) responders were exposed to mixture of dust, smoke, chemicals and carcinogens. New York University (NYU) and Mount Sinai have recreated WTC exposure in rodents to observe the resulting systemic and local biological re
Externí odkaz:
https://doaj.org/article/e242335de01247d4b50cabdb57c73a10
Autor:
Zachary A. Matthay, Zane J. Hellmann, Brenda Nunez-Garcia, Alexander T. Fields, Joseph Cuschieri, Matthew D. Neal, Jeffrey S. Berger, Elliot Luttrell-Williams, M. Margaret Knudson, Mitchell J. Cohen, Rachael A. Callcut, Lucy Z. Kornblith
Publikováno v:
The journal of trauma and acute care surgery. 93(5)
Posttraumatic venous thromboembolism (VTE) remains prevalent in severely injured patients despite chemoprophylaxis. Importantly, although platelets are central to thrombosis, they are not routinely targeted in prevention of posttraumatic VTE. Further
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::878067e71b45ef21ce85b61a5a8846cf
https://pubmed.ncbi.nlm.nih.gov/35444156
https://pubmed.ncbi.nlm.nih.gov/35444156