Zobrazeno 1 - 10
of 250
pro vyhledávání: '"Mitchell A. Avery"'
Autor:
Mohamed Jahan, Francisco Leon, Frank R. Fronczek, Khaled M. Elokely, John Rimoldi, Shabana I. Khan, Mitchell A. Avery
Publikováno v:
Molecules, Vol 26, Iss 14, p 4163 (2021)
An efficient synthesis of rac-6-desmethyl-5β–hydroxy-d-secoartemisinin 2, a tricyclic analog of R-(+)-artemisinin 1, was accomplished and the racemate was resolved into the (+)-2b and (−)-2a enantiomers via their Mosher Ester diastereomers. Anti
Externí odkaz:
https://doaj.org/article/59636c55b63643668d647005f941cecf
Publikováno v:
ARKIVOC, Vol 2011, Iss 7, Pp 297-311 (2011)
Externí odkaz:
https://doaj.org/article/1022d2f2f1c2445ead237fab1123c869
Publikováno v:
Acta Crystallographica Section E, Vol 69, Iss 3, Pp o410-o411 (2013)
Stevioside is a naturally occurring diterpenoid glycoside in Stevia rebaudiana Bertoni. The title compound, C38H60O18·4CH3OH, crystallized as its methanol tetrasolvate. Stevioside consists of an aglycone steviol (a tetracyclic diterpene in which the
Externí odkaz:
https://doaj.org/article/beb3c86198a54c8f835d7e8ba1ee0f07
Publikováno v:
Acta Crystallographica Section E, Vol 65, Iss 2, Pp o358-o359 (2009)
The title compound, C22H30O7, is a fused five-ring system that is of interest for its anticancer and antimalarial activity. The six-membered C6 and C5O rings display chair conformations. The six-membered C3O3 ring containing the ether and peroxy func
Externí odkaz:
https://doaj.org/article/c14a48bb71d64f1abb2a43e81ed4f146
Publikováno v:
Acta Crystallographica Section E, Vol 64, Iss 9, Pp o1686-o1686 (2008)
In the crystal structure of the title compound, C28H36O4S, the p-tolyl ring is inclined at 35.8° to the aromatic ring. The cyclohexene ring adopts a boat conformation and the heterocyclic ring is in a slightly distorted screw boat conformation.
Externí odkaz:
https://doaj.org/article/d00214169225484d9bcc46de9125d68c
Publikováno v:
Acta Crystallographica Section E, Vol 64, Iss 7, Pp o1370-o1371 (2008)
The salvinorin A analog dimethyl (2R,3aR,4R,6aR,7R,9S,9aS,9bS)-2-(3-furyl)-9,9a-dihydroxy-3a,6a-dimethyldodecahydrobenzo[de]chromene-4,7-dicarboxylate, C22H30O8, has a relatively simple spatial arrangement in which molecules are linked into layers by
Externí odkaz:
https://doaj.org/article/f5f549a6118b4c1ca6d99a0bed32b13c
Publikováno v:
Acta Crystallographica Section E, Vol 64, Iss 2, Pp o395-o396 (2008)
Crystals of the title compound [systematic name: (3R,6R,7S,8aR,9R,12aR)-7-hydroxy-3,6,9-trimethyloctahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one], C15H22O6, were obtained from microbial transformation of artemisinin by a culture of Cun
Externí odkaz:
https://doaj.org/article/fa0e62950593470f85007110dbeb713d
Autor:
Catherine M. Moore, Jigang Wang, Qingsong Lin, Pedro Ferreira, Mitchell A. Avery, Khaled Elokely, Henry M. Staines, Sanjeev Krishna
Treatment failures with artemisinin combination therapies (ACTs) threaten global efforts to eradicate malaria. They highlight the importance of identifying drug targets and new inhibitors and of studying how existing antimalarial classes work. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::556e13b777a2c72bfe1dbc05910e3000
https://openaccess.sgul.ac.uk/id/eprint/114308/1/aac.02079-21.pdf
https://openaccess.sgul.ac.uk/id/eprint/114308/1/aac.02079-21.pdf
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 84:129194
Autor:
Abir T. El-Alfy, Mitchell A. Avery, Xiong Zhang, Jakob Magolan, Anna J Kochanowska-Karamyan, Hugo C. Araujo, Mark T. Hamann, Paulo Carvalho, Stephen D Holmbo
Publikováno v:
Journal of Natural Products. 83:1092-1098
The natural product veranamine was isolated from the marine sponge Verongula rigida. It contains a unique heterocyclic scaffold and demonstrates in vivo antidepressant activity and selective affinity for 5HT2B and sigma-1 receptors. The first total s