Macrophages preserve endothelial cell specialization in the adrenal gland to modulate aldosterone secretion and blood pressure

Autor: Zheng Fan, Mara Karakone, Shunmugam Nagarajan, Nadine Nagy, Wiebke Mildenberger, Ekaterina Petrova, Laura Catharina Hinte, Mitchell Bijnen, Philipp Häne, Eric Nelius, Jing Chen, Irina Ferapontova, Ferdinand von Meyenn, Francesco Trepiccione, Mesut Berber, David Penton Ribas, Anne Eichmann, Maria-Christina Zennaro, Norihiko Takeda, Jens W. Fischer, Ariadni Spyroglou, Martin Reincke, Felix Beuschlein, Johannes Loffing, Melanie Greter, Christian Stockmann

Publikováno v: Cell Reports, Vol 43, Iss 7, Pp 114395- (2024)

Summary: Macrophages play crucial roles in organ-specific functions and homeostasis. In the adrenal gland, macrophages closely associate with sinusoidal capillaries in the aldosterone-producing zona glomerulosa. We demonstrate that macrophages preser

Externí odkaz: https://doaj.org/article/02b69b219d364673aaf81f6bfedf2bb0

Hepatic Fat Content and Liver Enzymes Are Associated with Circulating Free and Protein-Bound Advanced Glycation End Products, Which Are Associated with Low-Grade Inflammation: The CODAM Study

Autor: Mitchell Bijnen, Marleen M. J. van Greevenbroek, Carla J. H. van der Kallen, Jean L. Scheijen, Marjo P. H. van de Waarenburg, Coen D. A. Stehouwer, Kristiaan Wouters, Casper G. Schalkwijk

Publikováno v: Journal of Diabetes Research, Vol 2019 (2019)

Advanced glycation end products (AGEs) accumulate in fatty livers and may contribute to low-grade inflammation (LGI), potentially via their receptor, RAGE. It is unknown if the AGE accumulation in fatty livers results in elevated circulating AGEs. In

Externí odkaz: https://doaj.org/article/009eb056902c40e5b87a3ba6266b9119

Adipose tissue macrophages do not affect atherosclerosis development in mice

Autor: Mitchell Bijnen, Marion J.J. Gijbels, José van de Gaar, Casper G. Schalkwijk, Maria Vroomen, Kristiaan Wouters, Menno P.J. de Winther

Publikováno v: Atherosclerosis, 281, 31-37. Elsevier Ireland Ltd

Background and aims: Obese individuals have a higher risk of developing atherosclerosis, possibly driven by adipose tissue (AT) inflammation. We recently showed that AT macrophages (ATMs), which accumulate in the expanding obese AT, produce mediators

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8abc19bff5fc9d291fa84b219e6ca031
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85059866239&origin=inward

The endothelial function biomarker soluble E-selectin is associated with nonalcoholic fatty liver disease

Autor: Martijn C. G. J. Brouwers, Joline W.J. Beulens, Mitchell Bijnen, Coen D.A. Stehouwer, Carla J.H. van der Kallen, Leen M 't Hart, Casper G. Schalkwijk, Nicolaas C. Schaper, Jan Greve, Nynke Simons, Kristiaan Wouters, Marleen M.J. van Greevenbroek, Sander S. Rensen

Publikováno v: Liver International, 40(5), 1079-1088. WILEY
Liver International, 40(5), 1079-1088. Wiley
Liver International
Simons, N, Bijnen, M, Wouters, K A M, Rensen, S S, Beulens, J W J, van Greevenbroek, M M J, ’t Hart, L M, Greve, J W M, van der Kallen, C J H, Schaper, N C, Schalkwijk, C G, Stehouwer, C D A & Brouwers, M C G J 2020, ' The endothelial function biomarker soluble E-selectin is associated with nonalcoholic fatty liver disease ', Liver International, vol. 40, no. 5, pp. 1079-1088 . https://doi.org/10.1111/liv.14384
Liver International, 40(5), 1079-1088. Wiley-Blackwell

Background & Aims: Plasma soluble E-selectin (sE-selectin) is a frequently used biomarker of systemic endothelial dysfunction. The present study explored the relationship between nonalcoholic fatty liver disease (NAFLD) and plasma sE-selectin levels.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dd8b20ed24942d6452c49540db5f54e
https://hdl.handle.net/1887/3181501

MicroRNA-221/222 Family Counteracts Myocardial Fibrosis in Pressure Overload-Induced Heart Failure

Autor: Mitchell Bijnen, Tessa van Herwaarden, Michiel T H M Henkens, Wouter Verhesen, Marie-José Goumans, Marc van Bilsen, Frans A. van Nieuwenhoven, Arantxa González, Tim J Peters, Francisco J. Beaumont, Javier Díez, Rick van Leeuwen, Robin Verjans, Leon J. De Windt, Blanche Schroen, Stephane Heymans, Chantal Munts

Publikováno v: Frontiers in Cardiovascular Medicine
Hypertension, 71(2), 280-288. LIPPINCOTT WILLIAMS & WILKINS

Pressure overload causes cardiac fibroblast activation and transdifferentiation, leading to increased interstitial fibrosis formation and subsequently myocardial stiffness, diastolic and systolic dysfunction, and eventually heart failure. A better un

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03cabe8458cf9ee5b203b83c9261a907
https://doi.org/10.1161/hypertensionaha.117.10094