Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Mitchel Ruigrok"'
Publikováno v:
Expert Opinion on Drug Delivery. 19:1471-1485
Introduction: Injected mRNA vaccines have been proven effective and safe in the SARS-CoV-2 pandemic. Using the machinery of the cell, mRNA vaccines translate into an antigen, which triggers an adaptive immune response. The effectiveness of intramuscu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::988de8100bf2bfe523a501e96849ab0a
https://doi.org/10.1080/17425247.2022.2131767
https://doi.org/10.1080/17425247.2022.2131767
Publikováno v:
Frontiers in Medicine, Vol 8 (2022)
Frontiers in Medicine
Frontiers in Medicine
Great efforts have been made toward addressing the demand for donor kidneys. One of the most promising approaches is to use kidneys from donation after circulatory death donors. These kidneys, however, suffer from more severe ischemia and reperfusion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7920b666a957620d56a3927222bc684f
https://www.frontiersin.org/articles/10.3389/fmed.2021.806774/full
https://www.frontiersin.org/articles/10.3389/fmed.2021.806774/full
Autor:
Peter Olinga, Barbro N. Melgert, Henderik W. Frijlink, Wouter L. J. Hinrichs, Mitchel Ruigrok, Jia Ling Xian
Publikováno v:
AAPS PharmSci360
European Journal of Pharmaceutics and Biopharmaceutics, 133, 339-348. ELSEVIER SCIENCE BV
University of Groningen
European Journal of Pharmaceutics and Biopharmaceutics, 133, 339-348. ELSEVIER SCIENCE BV
University of Groningen
Small interfering RNA (siRNA) can induce RNA interference, which leads to the knockdown of messenger RNA (mRNA) and protein. As a result, siRNA is often used in vitro and in vivo to unravel the function of genes and as a therapeutic agent to disrupt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81fac0cae02c26a47bf75387a0304815
https://hdl.handle.net/11370/23eba869-2da3-4eab-b4b7-a64de5929aeb
https://hdl.handle.net/11370/23eba869-2da3-4eab-b4b7-a64de5929aeb
Autor:
Henderik W. Frijlink, Wouter L. J. Hinrichs, Diana Julie Leeming, Jannie M.B. Sand, Peter Olinga, Khaled E. M. El Amasi, Mitchel Ruigrok
Publikováno v:
Frontiers in Medicine
Frontiers in Medicine, 8:607962. Frontiers Media S.A.
Frontiers in Medicine, Vol 8 (2021)
Frontiers in Medicine, 8:607962. Frontiers Media S.A.
Frontiers in Medicine, Vol 8 (2021)
Idiopathic pulmonary fibrosis (IPF) is a chronic disease that is characterized by the excessive deposition of scar tissue in the lungs. As currently available treatments are unable to restore lung function in patients, there is an urgent medical need
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66b8f09735bd8cdd653f3d5034d9242a
https://hdl.handle.net/11370/c8b7909b-83ad-4e74-97c0-10c93a925ce0
https://hdl.handle.net/11370/c8b7909b-83ad-4e74-97c0-10c93a925ce0
Autor:
Peter Olinga, Barbro N. Melgert, Henderik W. Frijlink, Wouter L. J. Hinrichs, Jasmine Tomar, Mitchel Ruigrok
Publikováno v:
Scientific Reports, 9(1):16239. Nature Publishing Group
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports
Although animal models are often used in drug research, alternative experimental models are becoming more popular as they reduce animal use and suffering. Of particular interest are precision-cut lung slices, which refer to explants – with a reprod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a47fe70887028786dccea18f9c42e6b
https://research.rug.nl/en/publications/ecb6f1cb-d152-4e97-84b8-da6fef642600
https://research.rug.nl/en/publications/ecb6f1cb-d152-4e97-84b8-da6fef642600
Autor:
Mitchel Ruigrok
Idiopathic pulmonary fibrosis (IPF) is a disease with a poor prognosis that is marked by excessive scarring in the lungs, leading to breathlessness and, ultimately, death. To slow the progression of IPF, physicians often prescribe drugs, such as nint
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a788151c7e9977595a5743ce2e472234
https://doi.org/10.33612/diss.102801030
https://doi.org/10.33612/diss.102801030
Publikováno v:
Journal of Controlled Release. 235:14-23
Ever since the discovery of RNA interference (RNAi), which is a post-transcriptional gene silencing mechanism, researchers have been studying the therapeutic potential of using small interfering RNA (siRNA) to treat diseases that are characterized by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::308db8ab78691b69fe719352f01efc93
https://doi.org/10.1016/j.jconrel.2016.05.054
https://doi.org/10.1016/j.jconrel.2016.05.054
Publikováno v:
Transplantation. 104:S359-S359
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b2d77096a209a73a4ff82b56f7540fb
https://doi.org/10.1097/01.tp.0000700368.74161.34
https://doi.org/10.1097/01.tp.0000700368.74161.34
Autor:
Mitchel Ruigrok, Nalinie Maggan, Henderik W. Frijlink, Melgert, Barbro N., Peter Olinga, Wouter Hinrichs
Publikováno v:
11th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology
University of Groningen
University of Groningen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::6a5a2099f50128006c20350f1cf7991b
https://research.rug.nl/en/publications/4a58f30a-c357-4465-9820-4e3a9a6306d4
https://research.rug.nl/en/publications/4a58f30a-c357-4465-9820-4e3a9a6306d4
To investigate the effect of nanoparticulate impurities (NPIs) isolated from pharmaceutical-grade sucrose, on the stability of monoclonal antibodies (mAbs). NPIs were purified from pharmaceutical-grade sucrose and spiked into trastuzumab, rituximab,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9baaeee33e0c936baa00a2b53293296c
http://hdl.handle.net/1887/3202256
http://hdl.handle.net/1887/3202256