Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Mitcheell Maestre-Martínez"'
Autor:
Piotr Neumann, Frank Edlich, Milton T. Stubbs, Gunter Fischer, Christoph Parthier, Katja Haupt, Mitcheell Maestre-Martínez, Christian Lücke
Publikováno v:
Journal of Molecular Recognition. 24:23-34
The Bcl-2 inhibitor FKBP38 is regulated by the Ca(2+)-sensor calmodulin (CaM). Here we show a hitherto unknown low-affinity cation-binding site in the FKBP domain of FKBP38, which may afford an additional level of regulation based on electrostatic in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1c1fbb77ebe52cc0ee887d00b9559c4
https://doi.org/10.1002/jmr.1020
https://doi.org/10.1002/jmr.1020
Autor:
Nicolas Coudevylle, Olaf Jahn, Stefan Becker, Kalina Dimova, Mitcheell Maestre-Martínez, Harald J. Junge, Nils Brose, Noa Lipstein, Fernando Rodriguez-Castañeda, Christian Griesinger, Donghan Lee, Teresa Carlomagno
Publikováno v:
The EMBO Journal
Ca(2+) signalling in neurons through calmodulin (CaM) has a prominent function in regulating synaptic vesicle trafficking, transport, and fusion. Importantly, Ca(2+)-CaM binds a conserved region in the priming proteins Munc13-1 and ubMunc13-2 and thu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03c5dd593b6a7c68ab67c75c8d18e6c8
https://doi.org/10.1038/emboj.2009.373
https://doi.org/10.1038/emboj.2009.373
Publikováno v:
Magnetic Resonance in Chemistry. 47:16-30
Four types of polypeptide (1)J(C alpha X) couplings are examined, involving the main-chain carbon C(alpha) and either of four possible substituents. A total 3105 values of (1)J(C alpha H alpha), (1)J(C alpha C beta), (1)J(C alpha C'), and (1)J(C alph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06be2343d7404261c3e4b28e292d931a
https://doi.org/10.1002/mrc.2337
https://doi.org/10.1002/mrc.2337
Autor:
Sebastian Wolff, Christian Griesinger, Stefan Becker, Mitcheell Maestre-Martínez, Luigi Russo
Publikováno v:
Journal of the American Chemical Society
An ensemble-based approach is presented to explore the conformational space sampled by a multidomain protein showing moderate interdomain dynamics in terms of translational and rotational motions. The strategy was applied on a complex of calmodulin (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78307ed3885708b0370249c886f55d84
http://hdl.handle.net/11591/386803
http://hdl.handle.net/11591/386803
Autor:
Katja Haupt, Frank Edlich, Miriam Linnert, Mitcheell Maestre-Martínez, Arndt Pechstein, Christian Lücke, Miroslav Malesevic, Günther Jahreis
FKBP38 is a regulator of the prosurvival protein Bcl-2, but in the absence of detailed structural insights, the molecular mechanism of the underlying interaction has remained unknown. Here, we report the contact regions between Bcl-2 and the catalyti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b01ff1292e6f299660d9daf998e4332e
https://europepmc.org/articles/PMC3366001/
https://europepmc.org/articles/PMC3366001/
Autor:
Franziska Jarczowski, Gunter Fischer, Mitcheell Maestre-Martínez, Katja Haupt, Günther Jahreis, Christian Lücke, Frank Erdmann, Frank Edlich
Publikováno v:
Biological Chemistry. 391
The human FK506-binding protein 38 (FKBP38) regulates Bcl-2 in neuronal apoptosis. To control Bcl-2 activity, FKBP38 requires a prior interaction with the Ca2+-sensor calmodulin (CaM). The resulting FKBP38/CaM complex is unique within the FKBP family
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dafd72a4a896ebc6d2921264946e381
https://doi.org/10.1515/bc.2010.122
https://doi.org/10.1515/bc.2010.122
Publikováno v:
Magnetic resonance in chemistry : MRC. 47(1)
Four types of polypeptide (1)J(C alpha X) couplings are examined, involving the main-chain carbon C(alpha) and either of four possible substituents. A total 3105 values of (1)J(C alpha H alpha), (1)J(C alpha C beta), (1)J(C alpha C'), and (1)J(C alph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c62d011037e25b4e3e35a223f26d8612
https://pubmed.ncbi.nlm.nih.gov/18853398
https://pubmed.ncbi.nlm.nih.gov/18853398
Autor:
Günther Jahreis, Marie-Christine Moutty, Franziska Jarczowski, Gunter Fischer, Miroslav Malesevic, Frank Edlich, Christian Lücke, Matthias Weiwad, Mitcheell Maestre-Martínez
Publikováno v:
The Journal of biological chemistry. 282(50)
The FK506-binding protein 38 (FKBP38) affects neuronal apoptosis control by suppressing the anti-apoptotic function of Bcl-2. The direct interaction between FKBP38 and Bcl-2, however, requires a prior activation of FKBP38 by the Ca2+ sensor calmoduli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb1363dadbb2f0837fa370a7235f53b3
https://pubmed.ncbi.nlm.nih.gov/17942410
https://pubmed.ncbi.nlm.nih.gov/17942410
Autor:
Christian Lücke, Matthias Weiwad, Frank Edlich, Mitcheell Maestre-Martínez, Franziska Jarczowski, Gunter Fischer
Publikováno v:
Journal of biomolecular NMR. 34(3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::936ed6e965bc7177df278e2eb5c54ba9
https://pubmed.ncbi.nlm.nih.gov/16604427
https://pubmed.ncbi.nlm.nih.gov/16604427