Zobrazeno 1 - 10 of 19 pro vyhledávání: '"Mitch Phelps"'
1
Akademický článek
Pharmacokinetics and tolerability of multiple‐day oral dosing of mycophenolate mofetil in healthy horses
Autor: Kaitlyn Bello, Gwendolen Lorch, Kyeongmin Kim, Ramiro E. Toribio, Liwei Yan, Zhiliang Xie, Kasey Hill, Mitch Phelps
Publikováno v: Journal of Veterinary Internal Medicine, Vol 37, Iss 5, Pp 1907-1916 (2023)
Abstract Background Additional efficacious immunomodulatory treatment is needed for the management of immune‐mediated disease in horses. Mycophenolate mofetil (MMF) is an immunosuppressive drug that warrants assessment as a viable therapeutic agent
Externí odkaz: https://doaj.org/article/7da2714c8ebf4f81a68d9f0be846820b
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4
Akademický článek
Oral tetrahydrouridine and decitabine for non-cytotoxic epigenetic gene regulation in sickle cell disease: A randomized phase 1 study.
Autor: Robert Molokie, Donald Lavelle, Michel Gowhari, Michael Pacini, Lani Krauz, Johara Hassan, Vinzon Ibanez, Maria A Ruiz, Kwok Peng Ng, Philip Woost, Tomas Radivoyevitch, Daisy Pacelli, Sherry Fada, Matthew Rump, Matthew Hsieh, John F Tisdale, James Jacobberger, Mitch Phelps, James Douglas Engel, Santhosh Saraf, Lewis L Hsu, Victor Gordeuk, Joseph DeSimone, Yogen Saunthararajah
Publikováno v: PLoS Medicine, Vol 14, Iss 9, p e1002382 (2017)
BACKGROUND:Sickle cell disease (SCD), a congenital hemolytic anemia that exacts terrible global morbidity and mortality, is driven by polymerization of mutated sickle hemoglobin (HbS) in red blood cells (RBCs). Fetal hemoglobin (HbF) interferes with
Externí odkaz: https://doaj.org/article/c7733c856c0b41248e7cccfad4c6af2d
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5
Akademický článek
Registered report: Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs
Autor: Mitch Phelps, Chris Coss, Hongyan Wang, Matthew Cook, Reproducibility Project: Cancer Biology
Publikováno v: eLife, Vol 5 (2016)
The Reproducibility Project: Cancer Biology seeks to address growing concerns about reproducibility in scientific research by conducting replications of selected experiments from a number of high-profile papers in the field of cancer biology. The pap
Externí odkaz: https://doaj.org/article/44fc8c8eb9a3462191aa1828efdf5f6c
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6
Akademický článek
Toxicology and Biodistribution Studies for MGH2.1, an Oncolytic Virus that Expresses Two Prodrug-activating Genes, in Combination with Prodrugs
Autor: Kazue Kasai, Hiroshi Nakashima, Fang Liu, Samantha Kerr, Jiang Wang, Mitch Phelps, Philip M Potter, William B Goins, Soledad A Fernandez, E Antonio Chiocca
Publikováno v: Molecular Therapy: Nucleic Acids, Vol 2, Iss C (2013)
MGH2.1 is a herpes simplex virus type 1 (HSV1) oncolytic virus that expresses two prodrug-activating transgenes: the cyclophosphamide (CPA)-activating cytochrome P4502B1 (CYP2B1) and the CPT11-activating secreted human intestinal carboxylesterase (sh
Externí odkaz: https://doaj.org/article/7c6daeb645e8436c8b2554c83b6d87fd
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7
Akademický článek
Structurally modified curcumin analogs inhibit STAT3 phosphorylation and promote apoptosis of human renal cell carcinoma and melanoma cell lines.
Autor: Matthew A Bill, Courtney Nicholas, Thomas A Mace, Jonathan P Etter, Chenglong Li, Eric B Schwartz, James R Fuchs, Gregory S Young, Li Lin, Jiayuh Lin, Lei He, Mitch Phelps, Pui-Kai Li, Gregory B Lesinski
Publikováno v: PLoS ONE, Vol 7, Iss 8, p e40724 (2012)
The Janus kinase-2 (Jak2)-signal transducer and activator of transcription-3 (STAT3) pathway is critical for promoting an oncogenic and metastatic phenotype in several types of cancer including renal cell carcinoma (RCC) and melanoma. This study desc
Externí odkaz: https://doaj.org/article/5599ab05f7594c22bf3b3ba8343111bc
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