Interrogation of CYP2D6 Structural Variant Alleles Improves the Correlation Between CYP2D6 Genotype and CYP2D6‐Mediated Metabolic Activity

Autor: Rachel Dalton, Seung‐been Lee, Katrina G. Claw, Bhagwat Prasad, Brian R. Phillips, Danny D. Shen, Lai Hong Wong, Mitch Fade, Matthew G. McDonald, Maitreya J. Dunham, Douglas M. Fowler, Allan E. Rettie, Erin Schuetz, Timothy A. Thornton, Deborah A. Nickerson, Andrea Gaedigk, Kenneth E. Thummel, Erica L. Woodahl

Publikováno v: Clinical and Translational Science, Vol 13, Iss 1, Pp 147-156 (2020)

The cytochrome P450 2D6 (CYP2D6) gene locus is challenging to accurately genotype due to numerous single nucleotide variants and complex structural variation. Our goal was to determine whether the CYP2D6 genotype‐phenotype correlation is improved w

Externí odkaz: https://doaj.org/article/16a9484280914410be57114d167f3ce5

Interrogation of CYP2D6 Structural Variant Alleles Improves the Correlation Between CYP2D6 Genotype and CYP2D6‐Mediated Metabolic Activity.

Autor: Dalton, Rachel¹ (AUTHOR), Lee, Seung‐been² (AUTHOR), Claw, Katrina G.³ (AUTHOR), Prasad, Bhagwat³ (AUTHOR), Phillips, Brian R.³ (AUTHOR), Shen, Danny D.³ (AUTHOR), Wong, Lai Hong² (AUTHOR), Fade, Mitch² (AUTHOR), McDonald, Matthew G.⁴ (AUTHOR), Dunham, Maitreya J.² (AUTHOR), Fowler, Douglas M.² (AUTHOR), Rettie, Allan E.⁴ (AUTHOR), Schuetz, Erin⁵ (AUTHOR), Thornton, Timothy A.⁶ (AUTHOR), Nickerson, Deborah A.² (AUTHOR), Gaedigk, Andrea⁷ (AUTHOR), Thummel, Kenneth E.³ (AUTHOR), Woodahl, Erica L.¹ (AUTHOR) erica.woodahl@umontana.edu

Publikováno v: CTS: Clinical & Translational Science. Jan2020, Vol. 13 Issue 1, p147-156. 10p.

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