Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Mitch, McVey"'
Autor:
Varandt Khodaverdian, Tokio Sano, Lara R Maggs, Gina Tomarchio, Ana Dias, Mai Tran, Connor Clairmont, Mitch McVey
Publikováno v:
PLoS Genetics, Vol 20, Iss 7, p e1011181 (2024)
When replication forks encounter damaged DNA, cells utilize damage tolerance mechanisms to allow replication to proceed. These include translesion synthesis at the fork, postreplication gap filling, and template switching via fork reversal or homolog
Externí odkaz:
https://doaj.org/article/941897c6ec2641a1ba792ad0b728460b
Autor:
Steven J. Marygold, Helen Attrill, Elena Speretta, Kate Warner, Michele Magrane, Maria Berloco, Sue Cotterill, Mitch McVey, Yikang Rong, Masamitsu Yamaguchi
Publikováno v:
Fly, Vol 14, Iss 1-4, Pp 49-61 (2020)
DNA synthesis during replication or repair is a fundamental cellular process that is catalyzed by a set of evolutionary conserved polymerases. Despite a large body of research, the DNA polymerases of Drosophila melanogaster have not yet been systemat
Externí odkaz:
https://doaj.org/article/99e69527df4f42e0afe31ac2c92e38d3
Autor:
Terrence Hanscom, Nicholas Woodward, Rebecca Batorsky, Alexander J Brown, Steven A Roberts, Mitch McVey
Publikováno v:
Nucleic Acids Research. 50:7465-7478
Alternative end joining (alt-EJ) mechanisms, such as polymerase theta-mediated end joining, are increasingly recognized as important contributors to inaccurate double-strand break repair. We previously proposed an alt-EJ model whereby short DNA repea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44a94eadcc3da94ccea8db92e07fd14c
https://doi.org/10.1093/nar/gkac575
https://doi.org/10.1093/nar/gkac575
Autor:
Jacob M. Miller, Sydney Prange, Huanding Ji, Alesandra R. Rau, Avi Patel, Nadejda L. Butova, Avery Lutter, Helen Chung, Chiara Merigliano, Chetan C. Rawal, Terrence Hanscom, Mitch McVey, Irene Chiolo
Pericentromeric heterochromatin is highly enriched for repetitive sequences prone to aberrant recombination. Previous studies showed that homologous recombination (HR) repair is uniquely regulated in this domain to enable ‘safe’ repair while prev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf968c41a360d3e2a4c094341c382ce1
https://doi.org/10.1101/2023.03.03.531058
https://doi.org/10.1101/2023.03.03.531058
Autor:
Terrence Hanscom, Mitch McVey
Publikováno v:
Cells, Vol 9, Iss 7, p 1657 (2020)
Double-strand breaks are one of the most deleterious DNA lesions. Their repair via error-prone mechanisms can promote mutagenesis, loss of genetic information, and deregulation of the genome. These detrimental outcomes are significant drivers of huma
Externí odkaz:
https://doaj.org/article/88f949565f334f4285a82ae39bb3c2c9
Autor:
Kelly Beagan, Robin L Armstrong, Alice Witsell, Upasana Roy, Nikolai Renedo, Amy E Baker, Orlando D Schärer, Mitch McVey
Publikováno v:
PLoS Genetics, Vol 13, Iss 5, p e1006813 (2017)
Double strand breaks (DSBs) and interstrand crosslinks (ICLs) are toxic DNA lesions that can be repaired through multiple pathways, some of which involve shared proteins. One of these proteins, DNA Polymerase θ (Pol θ), coordinates a mutagenic DSB
Externí odkaz:
https://doaj.org/article/424f94cfac564df49822bba40c3fbed3
Autor:
Sara K. Martin, Mitch McVey
Publikováno v:
Molecular cell. 82(20)
Deshpande et al. (2022) demonstrate that BRCA1, a tumor suppressor tasked with protecting the genome, is encoded by a gene that is intrinsically fragile.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45303afba2fd391472dd93c1f5c4fe43
https://pubmed.ncbi.nlm.nih.gov/36270245
https://pubmed.ncbi.nlm.nih.gov/36270245
Rif1 plays important roles in the repair of DNA double-strand breaks in multiple organisms. In mammals, RIF1 promotes non-homologous end joining and suppresses homologous recombination by interacting with 53BP1 to inhibit resection. In Saccharomyces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18cb1d1a0e0e04f48eabb8ce3029f8cf
https://doi.org/10.1101/2022.05.24.493293
https://doi.org/10.1101/2022.05.24.493293
Autor:
Mitch McVey, Jan A. Pechenik
Publikováno v:
The American Biology Teacher. 82:416-420
Traditional assessments in college biology classrooms, such as exams and lab reports, often have limited utility in promoting long-lasting understanding of course material and do not always engage students from all backgrounds. The inclusion of creat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19462aee13fdcb6bbfe25185cbc80e63
https://doi.org/10.1525/abt.2020.82.6.416
https://doi.org/10.1525/abt.2020.82.6.416
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Scientific Reports
Sertraline hydrochloride is a commonly prescribed antidepressant medication that acts by amplifying serotonin signaling. Numerous studies have suggested that children of women taking sertraline during pregnancy have an increased risk of developmental
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::688df5a6b41373bb623c1ca7548e52f2
http://link.springer.com/article/10.1038/s41598-020-61362-y
http://link.springer.com/article/10.1038/s41598-020-61362-y