Pediatric Population Pharmacokinetic Modeling and Exposure–Response Analysis of Ambrisentan in Pulmonary Arterial Hypertension and Comparison With Adult Data

Autor: Malek Okour, Mita M. Thapar, Colm Farrell, Mary Ann Lukas, Maurice Beghetti, Misba Beerahee

Publikováno v: The Journal of Clinical Pharmacology. 63:593-603

This study aimed to develop a population pharmacokinetic (PK) model of ambrisentan in pediatric patients (8-18 years) with pulmonary arterial hypertension (PAH) and compare pediatric ambrisentan systemic exposure with previously reported adult data.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3a495e2e316b7a2954847aa79a5359f
https://doi.org/10.1002/jcph.2199

Pharmacodynamic interactions among atovaquone, proguanil and cycloguanil against Plasmodium falciparum in vitro

Autor: Carl Spindler, Walther H. Wernsdorfer, Mita M. Thapar, Seema Gupta, Anders Björkman

Publikováno v: Transactions of the Royal Society of Tropical Medicine and Hygiene. 97(3)

Synergistic interaction between atovaquone and proguanil has been suggested as the reason for the effectiveness of Malarone®. The pharmacodynamic interactions among atovaquone, proguanil and its metabolite cycloguanil were investigated in 4 Plasmodi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72a15e24ddc40b8f048b980d2477b23d
https://pubmed.ncbi.nlm.nih.gov/15228254

Time-dependent pharmacokinetics and drug metabolism of atovaquone plus proguanil (Malarone) when taken as chemoprophylaxis

Autor: Inger Johansson, Sabina Nivelius, Niklas Lindegårdh, Yngve Bergqvist, Michael Ashton, Mita M. Thapar, Anders Björkman

Publikováno v: European journal of clinical pharmacology. 58(1)

OBJECTIVE: To determine the pharmacokinetic profiles of atovaquone (ATO), proguanil (PROG) and its active metabolite cycloguanil (CYCLO) with respect to possible accumulation and kinetic interaction upon repeated dosing with Malarone. METHODS: Thirte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a73143a7fade1acd2d11373e68d7cda7
https://pubmed.ncbi.nlm.nih.gov/11956669

Population Pharmacokinetic Modeling of Dolutegravir to Optimize Pediatric Dosing in HIV-1-Infected Infants, Children, and Adolescents.

Autor: Chandasana H; Clinical Pharmacology, Modeling and Simulation, GSK, 1250 South Collegeville Road, Collegeville, PA, 19406, USA. hardik.x.chandasana@gsk.com., Thapar M; ICON, Reading, UK., Hayes S; ICON, Reading, UK., Baker M; ViiV Healthcare, Nyon, Switzerland., Gibb DM; Medical Research Council Clinical Trials Unit at University College London, London, UK., Turkova A; Medical Research Council Clinical Trials Unit at University College London, London, UK., Ford D; Medical Research Council Clinical Trials Unit at University College London, London, UK., Ruel T; University of California, San Francisco, San Francisco, CA, USA., Wiznia A; Jacobi Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA., Fairlie L; Faculty of Health Sciences, Wits RHI, University of the Witwatersrand, Johannesburg, South Africa., Bwakura-Dangarembizi M; Faculty of Medicine and Health Sciences, University of Zimbabwe, Harare, Zimbabwe., Mujuru H; Faculty of Medicine and Health Sciences, University of Zimbabwe, Harare, Zimbabwe., Alvero C; Frontier Science Foundation, Brookline, MA, USA., Farhad M; Frontier Science Foundation, Brookline, MA, USA., Hazra R; Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA., Townley E; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Buchanan A; ViiV Healthcare, Durham, NC, USA., Bollen P; Department of Pharmacy, Radboudumc Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, The Netherlands., Waalewijn H; Department of Pharmacy, Radboudumc Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, The Netherlands., Colbers A; Department of Pharmacy, Radboudumc Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, The Netherlands., Burger D; Department of Pharmacy, Radboudumc Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, The Netherlands., Acosta EP; University of Alabama at Birmingham, Birmingham, AL, USA., Singh R; Clinical Pharmacology, Modeling and Simulation, GSK, 1250 South Collegeville Road, Collegeville, PA, 19406, USA.

Publikováno v: Clinical pharmacokinetics [Clin Pharmacokinet] 2023 Oct; Vol. 62 (10), pp. 1445-1459. Date of Electronic Publication: 2023 Aug 21.

Population Pharmacokinetic and Pharmacodynamic Modeling and Effects on Platelet Counts of Different Dosages of Eltrombopag in Chinese Patients With Chronic Primary Immune Thrombocytopenia.

Autor: Wu K; Department of Clinical Pharmacology, Modeling and Simulation, GlaxoSmithKline, Shanghai, China., Thapar M; ICON Development Solutions, Marlow, United Kingdom., Farrell C; ICON Development Solutions, Marlow, United Kingdom., Hayes S; ICON Development Solutions, Marlow, United Kingdom., Guo H; China Medicine Development, GlaxoSmithKline, Shanghai, China., Hou M; Department of Hematology, Qilu Hospital, Shandong University, Shandong, China. Electronic address: houming@medmail.com.cn., Zhang J; Department of Clinical Pharmacology, Modeling and Simulation, GlaxoSmithKline, Research Triangle Park, North Carolina.

Publikováno v: Clinical therapeutics [Clin Ther] 2015 Jul 01; Vol. 37 (7), pp. 1382-95. Date of Electronic Publication: 2015 Apr 27.