Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Misun Won"'
Autor:
Tae-Hee Han, Joohan Lee, Dipesh S. Harmalkar, Hyeseul Kang, Guanghai Jin, Min Kyung Park, Minkyoung Kim, Hyun-A Yang, Jinsu Kim, Su Jeong Kwon, Tae-Su Han, Yongseok Choi, Misun Won, Hyun Seung Ban, Kyeong Lee
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 176, Iss , Pp 116838- (2024)
Hypoxia-inducible factor (HIF)-1α is a crucial transcription factor associated with cancer metabolism and is regarded as a potent anticancer therapeutic strategy within the hypoxic microenvironment of cancer. In this study, stilbenoid derivatives we
Externí odkaz:
https://doaj.org/article/d595514a20df4e729c00fddcaaa926bb
Autor:
Joo-Young Im, Soo Jin Kim, Jong-Lyul Park, Tae-Hee Han, Woo-il Kim, Inhyub Kim, Bomin Ko, So-Young Chun, Mi-Jung Kang, Bo-Kyung Kim, Sol A. Jeon, Seon-Kyu Kim, Incheol Ryu, Seon-Young Kim, Ki-Hoan Nam, Inah Hwang, Hyun Seung Ban, Misun Won
Publikováno v:
Experimental and Molecular Medicine, Vol 56, Iss 1, Pp 235-249 (2024)
Abstract Cytochrome b5 reductase 3 (CYB5R3) is involved in various cellular metabolic processes, including fatty acid synthesis and drug metabolism. However, the role of CYB5R3 in cancer development remains poorly understood. Here, we show that CYB5R
Externí odkaz:
https://doaj.org/article/0b08a891f6e7484ead7d40b35e5ac83c
Publikováno v:
Experimental and Molecular Medicine, Vol 55, Iss 5, Pp 879-885 (2023)
Abstract Increasing evidence indicates that DNA damage-induced apoptosis suppressor (DDIAS) is an oncogenic protein that is highly expressed in a variety of cancers, including colorectal cancer, lung cancer, breast cancer, and hepatocellular carcinom
Externí odkaz:
https://doaj.org/article/3ecfc6b6b79749cf8e1674ff3312a42b
Autor:
Bo-Kyung Kim, Da-Mi Kim, Hyunkyung Park, Seon-Kyu Kim, Mi-Aie Hwang, Jungwoon Lee, Mi-Jung Kang, Jae-Eun Byun, Joo-Young Im, Minho Kang, Kyung Chan Park, Young Il Yeom, Seon-Young Kim, Haiyoung Jung, Dae-Hyuk Kweon, Jae-Ho Cheong, Misun Won
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-17 (2022)
Abstract Background Identifying biomarkers related to the diagnosis and treatment of gastric cancer (GC) has not made significant progress due to the heterogeneity of tumors. Genes involved in histological classification and genetic correlation studi
Externí odkaz:
https://doaj.org/article/54003f4254e64e8b9a11049f59e4ca44
Design, Synthesis and Biological Evaluation of Novel MDH Inhibitors Targeting Tumor Microenvironment
Autor:
Sreenivasulu Godesi, Jeong-Ran Han, Jang-Keun Kim, Dong-Ik Kwak, Joohan Lee, Hossam Nada, Minkyoung Kim, Hyun-A Yang, Joo-Young Im, Hyun Seung Ban, Chang Hoon Lee, Yongseok Choi, Misun Won, Kyeong Lee
Publikováno v:
Pharmaceuticals, Vol 16, Iss 5, p 683 (2023)
MDH1 and MDH2 enzymes play an important role in the survival of lung cancer. In this study, a novel series of dual MDH1/2 inhibitors for lung cancer was rationally designed and synthesized, and their SAR was carefully investigated. Among the tested c
Externí odkaz:
https://doaj.org/article/8a1985dd73694d9e97e63647fd7dfd2c
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 1, p 376 (2022)
The tumor microenvironment comprising blood vessels, fibroblasts, immune cells, and the extracellular matrix surrounding cancer cells, has recently been targeted for research in cancer therapy. We aimed to investigate the effect of macrophages on the
Externí odkaz:
https://doaj.org/article/234fd14bfc6b408cb45b7dd637726d71
Autor:
Hyun Ji Kim, Mi Kyung Park, Hyun Jung Byun, Minkyoung Kim, Boram Kim, Lu Yu, Tuan Minh Nguyen, Thi Ha Nguyen, Phuong Anh Do, Eun Ji Kim, Ji Hyun Kim, Enkhmend Enkhtaivan, Kyung Sung Kim, Ji Yun Jang, Gyeoung Jin Kang, Ho Lee, Misun Won, Kyeong Lee, Jungsook Cho, Chang Hoon Lee
Publikováno v:
Antioxidants, Vol 10, Iss 11, p 1674 (2021)
LW1497 suppresses the expression of the hypoxia-inducing factor (HIF)-1α inhibiting malate dehydrogenase. Although hypoxia and HIF-1α are known to be important in cancer, LW1497 has not been therapeutically applied to cancer yet. Thus, we investiga
Externí odkaz:
https://doaj.org/article/141c8b24db014edda9b8f8ddc25a88ea
Autor:
Joo-Young Im, Sung-Hoon Yoon, Bo-Kyung Kim, Hyun Seung Ban, Kyoung-Jae Won, Kyung-Sook Chung, Kyeong Eun Jung, Misun Won
Publikováno v:
Data in Brief, Vol 9, Iss C, Pp 257-261 (2016)
The data included in this article are associated with the article entitled “DNA-damage-induced apoptosis suppressor (DDIAS) is upregulated via ERK5/MEF2B signaling and promotes β-catenin-mediated invasion” (J.Y. Im, S.H. Yoon, B.K. Kim, H.S. Ban
Externí odkaz:
https://doaj.org/article/8f5a0921dc444bfc964f6f0c39e7c65d
Autor:
Joo-Young Im, Kang-Woo Lee, Kyoung-Jae Won, Bo-Kyung Kim, Hyun Seung Ban, Sung-Hoon Yoon, Young-Ju Lee, Young-Joo Kim, Kyung-Bin Song, Misun Won
Publikováno v:
Data in Brief, Vol 5, Iss C, Pp 975-980 (2015)
DNA damage induced apoptosis suppressor (DDIAS), or human Noxin (hNoxin), is strongly expressed in lung cancers. DDIAS knockdown induced apoptosis in non-small cell lung carcinoma A549 cells in response to DNA damage, indicating DDIAS as a potential
Externí odkaz:
https://doaj.org/article/e2f91985ef824cc5a992dc7e88eeeebe
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162568 (2016)
We previously reported that hypoxia-inducible factor (HIF)-1 inhibitor LW6, an aryloxyacetylamino benzoic acid derivative, inhibits malate dehydrogenase 2 (MDH2) activity during the mitochondrial tricarboxylic acid (TCA) cycle. In this study, we pres
Externí odkaz:
https://doaj.org/article/bc7cb153bbe94ae2bf26aa196336f152