Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Misuk Kang"'
Publikováno v:
Bioorganicmedicinal chemistry letters. 56
Sodium-dependent glucose co-transporter 2 (SGLT2) has emerged as a promising drug target for the treatment of type 2 diabetes, and recently, several SGLT2 inhibitors have been approved for clinical use. A series of molecules with a C-aryl glucoside s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7461a923e19bbff3943ef43c63df259c
https://pubmed.ncbi.nlm.nih.gov/34813882
https://pubmed.ncbi.nlm.nih.gov/34813882
Autor:
Ka Young Chung, Misuk Kang
Publikováno v:
Biochemical and Biophysical Research Communications. 423:600-605
Endothelin-1 (ET-1) induces positive inotropy (enhanced contractility) in cardiac muscle, but establishing underlying cellular mechanisms has been controversial in part because of a growing number of signaling pathways and end effectors targeted by E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a300307ee4114ecd54641554f1ebe925
https://doi.org/10.1016/j.bbrc.2012.06.024
https://doi.org/10.1016/j.bbrc.2012.06.024
Autor:
Kwang-Seop Song, Suk Ho Lee, Hyun-Ju Park, Jeongmin Kim, Jong Yup Kim, Seung-Hwan Cho, Misuk Kang, Jinhwa Lee, Jun Sung Lee
Publikováno v:
Bioorganic & Medicinal Chemistry. 19:5813-5832
Novel thiophene C-aryl glucoside SGLT2 inhibitors were designed and synthesized. Two different types of thiophene derivatives were readily prepared. Among the compounds tested, ethylphenyl at the distal ring 71p showed the best in vitro inhibitory ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::987f606e2db287339e5138d7b89429d3
https://doi.org/10.1016/j.bmc.2011.08.014
https://doi.org/10.1016/j.bmc.2011.08.014
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 294:H2391-H2399
Endothelin (ET)-1 regulates the contractility and growth of the heart by binding G protein-coupled receptors of the ET type A receptor (ETA)/ET type B (ETB) receptor family. ETA, the predominant ET-1 receptor subtype in myocardium, is thought to loca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e24af60dcd1b430775025abc56aa5d52
https://doi.org/10.1152/ajpheart.00011.2008
https://doi.org/10.1152/ajpheart.00011.2008
PICOT Inhibits Cardiac Hypertrophy and Enhances Ventricular Function and Cardiomyocyte Contractility
Autor:
Ji Myoung Kim, Susumu Sakata, Woo Jin Park, Eun Young Kim, Dong Kwon Yang, Sun-Hee Woo, Roger J. Hajjar, Dongtak Jeong, Hyeseon Cha, Lei Cui, Young-Hoon Lee, Le Thi Thu, Jae Gyun Oh, Do Han Kim, Ronglih Liao, Oliver Y. Bernecker, Misuk Kang, Pyoung Oh Yoon
Publikováno v:
Circulation Research. 99:307-314
Multiple signaling pathways involving protein kinase C (PKC) have been implicated in the development of cardiac hypertrophy. We observed that a putative PKC inhibitor, PICOT ( P KC- I nteracting C ousin O f T hioredoxin) was upregulated in response t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe2a3f114a7f8ede7c4f215b0a317b6e
https://doi.org/10.1161/01.res.0000234780.06115.2c
https://doi.org/10.1161/01.res.0000234780.06115.2c
Autor:
Misuk Kang, Jeffery W. Walker
Publikováno v:
Journal of Molecular and Cellular Cardiology. 38:753-764
To examine cardiac contractile regulation and protein kinase C (PKC) translocation in parallel, the delta and epsilon isoforms of PKC were fused to green fluorescent protein (GFP) and expressed in adult rat ventricular myocytes maintained in short te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ee2ded91fd9f9953c6d053f07dc0b96
https://doi.org/10.1016/j.yjmcc.2005.02.017
https://doi.org/10.1016/j.yjmcc.2005.02.017
Publikováno v:
Biotechnology and bioengineering. 110(11)
Corynebacterium glutamicum is an important industrial organism that is widely used in the production of amino acids, nucleotides and vitamins. To extend its product spectrum and improve productivity, C. glutamicum needs to undergo further engineering
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2ffe6b4cee2c21f7d649f3f8e37c91f4
https://pubmed.ncbi.nlm.nih.gov/23633298
https://pubmed.ncbi.nlm.nih.gov/23633298
Publikováno v:
Physiology (Bethesda, Md.). 22
Catecholamines, endothelin-1 and angiotensin II are among a diverse group of diffusible extracellular signals that regulate pump function of the heart by binding to G-protein coupled receptors (GPCR). When the body demands a temporary boost of power
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd9f667eb113cf32cfcf07edf6d5ff3b
https://pubmed.ncbi.nlm.nih.gov/17557938
https://pubmed.ncbi.nlm.nih.gov/17557938
Autor:
Misuk, Kang, Jeffery W, Walker
Publikováno v:
Experimental biology and medicine (Maywood, N.J.). 231(6)
It has been proposed that intracellular alkalinization underlies the enhanced contractility of ventricular myocytes exposed to endothelin (ET)-1. The effects of ET-1 on the contractility and intracellular pH (pH(i)) were examined here in cultured adu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eae275f3edc3f14d762e169312bcabb5
https://pubmed.ncbi.nlm.nih.gov/16741014
https://pubmed.ncbi.nlm.nih.gov/16741014
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 289(5)
The Z-line represents a critical link between the transverse tubule network and cytoskeleton of cardiac cells with a role in anchoring structural proteins, ion channels, and signaling molecules. Protein kinase C-ε (PKC-ε) regulates cardiac excitabi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eb4cc66351d76ea34e3782d590385b0
https://pubmed.ncbi.nlm.nih.gov/15964917
https://pubmed.ncbi.nlm.nih.gov/15964917