Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Misty M. Attwood"'
Autor:
Mohamed H. Al-Sabri, Maryam Nikpour, Laura E. Clemensson, Misty M. Attwood, Michael J. Williams, Mathias Rask-Anderson, Jessica Mwinyi, Helgi B. Schiöth
Publikováno v:
Cell & Bioscience, Vol 12, Iss 1, Pp 1-20 (2022)
Abstract Monoaminergic neurotransmitter systems play a central role in neuronal function and behaviour. Dysregulation of these systems gives rise to neuropsychiatric and neurodegenerative disorders with high prevalence and societal burden, collective
Externí odkaz:
https://doaj.org/article/25cad3bf46fa4012b801ae3e40292cf9
Autor:
Timofey O. Klyucherev, Pawel Olszewski, Alena A. Shalimova, Vladimir N. Chubarev, Vadim V. Tarasov, Misty M. Attwood, Stina Syvänen, Helgi B. Schiöth
Publikováno v:
Translational Neurodegeneration, Vol 11, Iss 1, Pp 1-24 (2022)
Abstract Alzheimer's disease (AD) is a complex, heterogeneous, progressive disease and is the most common type of neurodegenerative dementia. The prevalence of AD is expected to increase as the population ages, placing an additional burden on nationa
Externí odkaz:
https://doaj.org/article/f56a63ad026244c5a41ddc10feb525cc
Autor:
Andrey D. Bondarev, Misty M. Attwood, Jörgen Jonsson, Vladimir N. Chubarev, Vadim V. Tarasov, Wen Liu, Helgi B. Schiöth
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
The phosphodiesterase (PDE) enzymes, key regulator of the cyclic nucleotide signal transduction system, are long-established as attractive therapeutic targets. During investigation of trends within clinical trials, we have identified a particularly h
Externí odkaz:
https://doaj.org/article/a72af28bc4344e818bb63535d3d11b6c
Autor:
Amelia D. Dahlén, Giovanna Dashi, Ivan Maslov, Misty M. Attwood, Jörgen Jonsson, Vladimir Trukhan, Helgi B. Schiöth
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2022)
Type 2 diabetes mellitus (T2DM) continues to be a substantial medical problem due to its increasing global prevalence and because chronic hyperglycemic states are closely linked with obesity, liver disease and several cardiovascular diseases. Since t
Externí odkaz:
https://doaj.org/article/af5b91bb11d5434bb911a2c774ac0e2b
Autor:
Misty M. Attwood, Helgi B. Schiöth
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Transmembrane proteins are involved in many essential cell processes such as signal transduction, transport, and protein trafficking, and hence many are implicated in different disease pathways. Further, as the structure and function of proteins are
Externí odkaz:
https://doaj.org/article/34063f4fb63c4c89b49b2b1b68de5c8f
Autor:
Misty M. Attwood, Helgi B. Schiöth
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2020)
As the structure and functions of proteins are correlated, investigating groups of proteins with the same gross structure may provide important insights about their functional roles. Trispanins, proteins that contain three alpha-helical transmembrane
Externí odkaz:
https://doaj.org/article/b392f03455724aa4af350c939479f3bd
Autor:
Maija Dambrova, Marina Makrecka-Kuka, Janis Kuka, Reinis Vilskersts, Didi Nordberg, Misty M. Attwood, Stefan Smesny, Zumrut Duygu Sen, An Chi Guo, Eponine Oler, Siyang Tian, Jiamin Zheng, David S. Wishart, Edgars Liepinsh, Helgi B. Schiöth
Publikováno v:
Pharmacological Reviews. 74:506-551
Acylcarnitines are fatty acid metabolites that play important roles in many cellular energy metabolism pathways. They have historically been used as important diagnostic markers for inborn errors of fatty acid oxidation and are being intensively stud
Autor:
Aziza Ben Kraiem, Misty M. Attwood, Jessica Mwinyi, Vadim V. Tarasov, Vladimir N. Chubarev, Farzin Zobdeh, Helgi B. Schiöth
Publikováno v:
British Journal of Pharmacology. 178:4588-4607
Migraine is the sixth most prevalent disease globally, a major cause of disability, and it imposes an enormous personal and socioeconomic burden. Migraine treatment is often limited by insufficient therapy response, leading to the need for individual
Publikováno v:
Nature Reviews Drug Discovery. 20:839-861
The FDA approval of imatinib in 2001 was a breakthrough in molecularly targeted cancer therapy and heralded the emergence of kinase inhibitors as a key drug class in the oncology area and beyond. Twenty years on, this article analyses the landscape o
Autor:
Debraj Basu, Jenish Maharjan, Angier Allen, Rahul Thapa, Misty M Attwood, Myrna Hurtado, Zohora Iqbal, Jana Hoffman
Background Despite the emergence of several promising machine learning models for prediction of patients at risk of sepsis, investigation of factors that contribute to false positive rates has not been performed. Here, we conducted a false positive a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4a9b0d5f0814784e9cdf0f9ab4ae545
https://doi.org/10.21203/rs.3.rs-1746922/v1
https://doi.org/10.21203/rs.3.rs-1746922/v1