Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Misty Chen-Goodspeed"'
Publikováno v:
Journal of Circadian Rhythms, Vol 11 (2013)
Background: Our recent studies demonstrate that the murine homolog of the human tumor suppressor promyelocytic leukemia (PML) regulates circadian behavior of mice. To further gather insight into PML’s contribution to circadian behavior, we generate
Externí odkaz:
https://doaj.org/article/0223903c1c7e437a87c084a159d3a913
Autor:
Michael A. Rea, Zhi-Xiang Xu, Zhaoyang Zhao, Anita Van Oort-Jansen, Cheng Chi Lee, Takao Miki, Kun Sang Chang, Mingguang Liu, Misty Chen-Goodspeed
Publikováno v:
The EMBO Journal. 31:1427-1439
Studies have suggested that the clock regulator PER2 is a tumour suppressor. A cancer network involving PER2 raises the possibility that some tumour suppressors are directly involved in the mammalian clock. Here, we show that the tumour suppressor pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92ebdeb4b30449529d70003ad8833252
https://doi.org/10.1038/emboj.2012.1
https://doi.org/10.1038/emboj.2012.1
Publikováno v:
Journal of Biological Chemistry. 280:1808-1816
We examined the kinetics of Galpha(s) and Galpha(i) regulation of human type V and type VI adenylyl cyclase (AC V and AC VI) in order to better model interactions between AC and its regulators. Activation of AC VI by Galpha(s) displayed classical Mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f38c3b0fedcc8945bdcbaabf5f90795
https://doi.org/10.1074/jbc.m409172200
https://doi.org/10.1074/jbc.m409172200
Publikováno v:
Bioorganic & Medicinal Chemistry. 9:2083-2091
The catalytic activity of the bacterial phosphotriesterase (PTE) toward a series of chiral analogues of the chemical warfare agents sarin and soman was measured. Chemical procedures were developed for the chiral syntheses of the S P - and R P -enanti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f20a60f07211eacde9ac4f8b63703ef
https://doi.org/10.1016/s0968-0896(01)00113-4
https://doi.org/10.1016/s0968-0896(01)00113-4
Publikováno v:
Biochemistry. 40:1332-1339
The factors that govern the substrate reactivity and stereoselectivity of phosphotriesterase (PTE) toward organophosphotriesters containing various combinations of methyl, ethyl, isopropyl, and phenyl substituents at the phosphorus center were determ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d27f9dad7845fc201cef9d5af54557f
https://doi.org/10.1021/bi001549d
https://doi.org/10.1021/bi001549d
Publikováno v:
Bioorganic Chemistry. 27:395-408
Kanamycin nucleotidyltransferase (KNTase) catalyzes the transfer of the adenyl group from MgATP to either the 4′ or 4″-hydroxyl group of aminoglycoside antibiotics. The steady state kinetic parameters of the enzymatic reaction have been measured
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bcf09e3d21bc4d0c88c0b3cd5a41c32d
https://doi.org/10.1006/bioo.1999.1144
https://doi.org/10.1006/bioo.1999.1144
Publikováno v:
Proteins: Structure, Function, and Genetics. 29:553-561
Phosphotriesterase (PTE) is a zinc metalloenzyme that catalyzes the hydro- lysis of an extensive array of organophosphate pesticides and mammalian acetylcholinester- ase nerve agents. Although the three-dimen- sional crystal structure of PTE has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a518ee234498a34d9914d37b624a60d
https://doi.org/10.1002/(sici)1097-0134(199712)29:4<553::aid-prot14>3.0.co
https://doi.org/10.1002/(sici)1097-0134(199712)29:4<553::aid-prot14>3.0.co
Publikováno v:
The Journal of biological chemistry. 280(3)
We examined the kinetics of Galpha(s) and Galpha(i) regulation of human type V and type VI adenylyl cyclase (AC V and AC VI) in order to better model interactions between AC and its regulators. Activation of AC VI by Galpha(s) displayed classical Mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3beaf8f4d19421cae25b26265e00fc66
https://pubmed.ncbi.nlm.nih.gov/15545274
https://pubmed.ncbi.nlm.nih.gov/15545274
Publikováno v:
The Journal of biological chemistry. 277(32)
The topology of mammalian adenylyl cyclase reveals an integral membrane protein composed of an alternating series of membrane and cytoplasmic domains (C1 and C2). The stimulatory G protein, Galpha(s), binds within a cleft in the C2 domain of adenylyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23e82b1822c59118dc2777d8eef9994a
https://pubmed.ncbi.nlm.nih.gov/12058044
https://pubmed.ncbi.nlm.nih.gov/12058044
Publikováno v:
ChemInform. 32
will catalyze the hydrolysis of the most acidic phenolic substituent from an organophosphate triester. The overall rate of hydrolysis is very much dependent on the pKa of the leaving group phenol. 4b To enhance the substrate stereoselectivity exhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12a283f0ae8a2516bffc6e7ec47dd44a
https://doi.org/10.1002/chin.200108177
https://doi.org/10.1002/chin.200108177