Importance of the Cysteine-Rich Domain of Snake Venom Prothrombin Activators: Insights Gained from Synthetic Neutralizing Antibodies.

Autor: Misson Mindrebo LE; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; International AIDS Vaccine Initiative, New York, NY 10004, USA., Mindrebo JT; Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA 92037, USA., Tran Q; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; International AIDS Vaccine Initiative, New York, NY 10004, USA., Wilkinson MC; Centre for Snakebite Research & Interventions, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK., Smith JM; International AIDS Vaccine Initiative, New York, NY 10004, USA., Verma M; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; International AIDS Vaccine Initiative, New York, NY 10004, USA., Casewell NR; Centre for Snakebite Research & Interventions, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK., Lander GC; Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA 92037, USA., Jardine JG; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; International AIDS Vaccine Initiative, New York, NY 10004, USA.

Publikováno v: Toxins [Toxins (Basel)] 2024 Aug 15; Vol. 16 (8). Date of Electronic Publication: 2024 Aug 15.