Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Misook Choe"'
Autor:
Alexandra A. Abu-Shmais, Matthew J. Vukovich, Perry T. Wasdin, Yukthi P. Suresh, Toma M. Marinov, Scott A. Rush, Rebecca A. Gillespie, Rajeshwer S. Sankhala, Misook Choe, M. Gordon Joyce, Masaru Kanekiyo, Jason S. McLellan, Ivelin S. Georgiev
Publikováno v:
mBio, Vol 15, Iss 10 (2024)
ABSTRACT Throughout life, humans experience repeated exposure to viral antigens through infection and vaccination, resulting in the generation of diverse, antigen-specific antibody repertoires. A paramount feature of antibodies that enables their cri
Externí odkaz:
https://doaj.org/article/675d59ae3e40446aa12faa2f3e327029
Autor:
Elizabeth J. Martinez, William C. Chang, Wei-Hung Chen, Agnes Hajduczki, Paul V. Thomas, Jaime L. Jensen, Misook Choe, Rajeshwer S. Sankhala, Caroline E. Peterson, Phyllis A. Rees, Jordan Kimner, Sandrine Soman, Caitlin Kuklis, Letzibeth Mendez-Rivera, Vincent Dussupt, Jocelyn King, Courtney Corbett, Sandra V. Mayer, Aldon Fernandes, Kripa Murzello, Tres Cookenham, Janine Hvizdos, Larry Kummer, Tricia Hart, Kathleen Lanzer, Julian Gambacurta, Matthew Reagan, Debbie Duso, Sandhya Vasan, Natalie D. Collins, Nelson L. Michael, Shelly J. Krebs, Gregory D. Gromowski, Kayvon Modjarrad, John Kaundinya, M. Gordon Joyce
Publikováno v:
iScience, Vol 27, Iss 10, Pp 110624- (2024)
Summary: The rapid emergence of SARS-CoV-2 variants of concern (VoC) and the threat of future zoonotic sarbecovirus spillover emphasizes the need for broadly protective next-generation vaccines and therapeutics. We utilized SARS-CoV-2 spike ferritin
Externí odkaz:
https://doaj.org/article/d044a7b730b34c81a3817a63324aa1dd
Autor:
Cuiping Liu, Lingshu Wang, Jonah S. Merriam, Wei Shi, Eun Sung Yang, Yi Zhang, Man Chen, Wing-Pui Kong, Cheng Cheng, Yaroslav Tsybovsky, Tyler Stephens, Raffaello Verardi, Kwanyee Leung, Cody Stein, Adam S. Olia, Darcy R. Harris, Misook Choe, Baoshan Zhang, Barney S. Graham, Peter D. Kwong, Richard A. Koup, Amarendra Pegu, John R. Mascola
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-10 (2023)
Abstract While several COVID-19 vaccines have been in use, more effective and durable vaccines are needed to combat the ongoing COVID-19 pandemic. Here, we report highly immunogenic self-assembling SARS-CoV-2 spike-HBsAg nanoparticles displaying a si
Externí odkaz:
https://doaj.org/article/9b37253d44914adeb9ec845f4062bcd4
Autor:
Wei-Hung Chen, Agnes Hajduczki, Elizabeth J. Martinez, Hongjun Bai, Hanover Matz, Thomas M. Hill, Eric Lewitus, William C. Chang, Layla Dawit, Caroline E. Peterson, Phyllis A. Rees, Adelola B. Ajayi, Emily S. Golub, Isabella Swafford, Vincent Dussupt, Sapna David, Sandra V. Mayer, Sandrine Soman, Caitlin Kuklis, Courtney Corbitt, Jocelyn King, Misook Choe, Rajeshwer S. Sankhala, Paul V. Thomas, Michelle Zemil, Lindsay Wieczorek, Tricia Hart, Debora Duso, Larry Kummer, Lianying Yan, Spencer L. Sterling, Eric D. Laing, Christopher C. Broder, Jazmean K. Williams, Edgar Davidson, Benjamin J. Doranz, Shelly J. Krebs, Victoria R. Polonis, Dominic Paquin-Proulx, Morgane Rolland, William W. Reiley, Gregory D. Gromowski, Kayvon Modjarrad, Helen Dooley, M. Gordon Joyce
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
SARS-CoV-2 variants of concern continue to emerge, reducing vaccine efficacy and limiting therapeutic options. Here, Chen and colleagues describe the identification and design of shark nanobodies with pansarbecovirus activity.
Externí odkaz:
https://doaj.org/article/898fe823bbf4468ea5527a2d0a41fa28
Autor:
Rajeshwer S. Sankhala, Vincent Dussupt, Gina Donofrio, Gregory D. Gromowski, Rafael A. De La Barrera, Rafael A. Larocca, Letzibeth Mendez-Rivera, Anna Lee, Misook Choe, Weam Zaky, Grace Mantus, Jaime L. Jensen, Wei-Hung Chen, Neelakshi Gohain, Hongjun Bai, Michael K. McCracken, Rosemarie D. Mason, David Leggat, Bonnie M. Slike, Ursula Tran, Ningbo Jian, Peter Abbink, Rebecca Peterson, Eric Araujo Mendes, Rafael Freitas de Oliveira Franca, Guilherme Amaral Calvet, Ana Maria Bispo de Filippis, Adrian McDermott, Mario Roederer, Mayda Hernandez, Amie Albertus, Edgar Davidson, Benjamin J. Doranz, Morgane Rolland, Merlin L. Robb, Rebecca M. Lynch, Dan H. Barouch, Richard G. Jarman, Stephen J. Thomas, Kayvon Modjarrad, Nelson L. Michael, Shelly J. Krebs, M. Gordon Joyce
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112942- (2023)
Summary: Zika virus (ZIKV) is an emerging pathogen that causes devastating congenital defects. The overlapping epidemiology and immunologic cross-reactivity between ZIKV and dengue virus (DENV) pose complex challenges to vaccine design, given the pot
Externí odkaz:
https://doaj.org/article/df7415563897410eaec20a0810786ea8
Autor:
Shraddha Basu, Neelakshi Gohain, Jiae Kim, Hung V. Trinh, Misook Choe, M. Gordon Joyce, Mangala Rao
Publikováno v:
Cells, Vol 13, Iss 1, p 33 (2023)
Developing a preventative vaccine for HIV-1 has been a global priority. The elicitation of broadly neutralizing antibodies (bNAbs) against a broad range of HIV-1 envelopes (Envs) from various strains appears to be a critical requirement for an effica
Externí odkaz:
https://doaj.org/article/94b557cde4d44f99a6f099511f0e68ac
Autor:
Zhantong Wang, Baoshan Zhang, Li Ou, Qi Qiu, Lingshu Wang, Tatsiana Bylund, Wing-Pui Kong, Wei Shi, Yaroslav Tsybovsky, Lingyuan Wu, Qiong Zhou, Ridhi Chaudhary, Misook Choe, Thayne H. Dickey, Mohammed El Anbari, Adam S. Olia, Reda Rawi, I-Ting Teng, Danyi Wang, Shuishu Wang, Niraj H. Tolia, Tongqing Zhou, Peter D. Kwong
Publikováno v:
Vaccines, Vol 12, Iss 1, p 37 (2023)
The receptor-binding domain (RBD) of the SARS-CoV-2 spike is a primary target of neutralizing antibodies and a key component of licensed vaccines. Substantial mutations in RBD, however, enable current variants to escape immunogenicity generated by va
Externí odkaz:
https://doaj.org/article/5a6e533b068544d5a92eea9c86896ad3
Autor:
Sarah E. Lovelace, Sabrina Helmold Hait, Eun Sung Yang, Madison L. Fox, Cuiping Liu, Misook Choe, Xuejun Chen, Elizabeth McCarthy, John-Paul Todd, Ruth A. Woodward, Richard A. Koup, John R. Mascola, Amarendra Pegu
Publikováno v:
iScience, Vol 25, Iss 10, Pp 105067- (2022)
Summary: Broadly neutralizing antibodies (bNAbs) against HIV-1 are promising immunotherapeutic agents for treatment of HIV-1 infection. bNAbs can be administered to SHIV-infected rhesus macaques to assess their anti-viral efficacy; however, their del
Externí odkaz:
https://doaj.org/article/e67fba8088444e1197904baa6ce1582e
Autor:
Merricka C. Livingstone, Alexis A. Bitzer, Alish Giri, Kun Luo, Rajeshwer S. Sankhala, Misook Choe, Xiaoyan Zou, S. Moses Dennison, Yuanzhang Li, William Washington, Viseth Ngauy, Georgia D. Tomaras, M. Gordon Joyce, Adrian H. Batchelor, Sheetij Dutta
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Plasmodium falciparum malaria contributes to a significant global disease burden. Circumsporozoite protein (CSP), the most abundant sporozoite stage antigen, is a prime vaccine candidate. Inhibitory monoclonal antibodies (mAbs) against CSP m
Externí odkaz:
https://doaj.org/article/f735407d93c347bfbd54ca0405a5bab5
Autor:
Kathryn Westendorf, Stefanie Žentelis, Lingshu Wang, Denisa Foster, Peter Vaillancourt, Matthew Wiggin, Erica Lovett, Robin van der Lee, Jörg Hendle, Anna Pustilnik, J. Michael Sauder, Lucas Kraft, Yuri Hwang, Robert W. Siegel, Jinbiao Chen, Beverly A. Heinz, Richard E. Higgs, Nicole L. Kallewaard, Kevin Jepson, Rodrigo Goya, Maia A. Smith, David W. Collins, Davide Pellacani, Ping Xiang, Valentine de Puyraimond, Marketa Ricicova, Lindsay Devorkin, Caitlin Pritchard, Aoise O’Neill, Kush Dalal, Pankaj Panwar, Harveer Dhupar, Fabian A. Garces, Courtney A. Cohen, John M. Dye, Kathleen E. Huie, Catherine V. Badger, Darwyn Kobasa, Jonathan Audet, Joshua J. Freitas, Saleema Hassanali, Ina Hughes, Luis Munoz, Holly C. Palma, Bharathi Ramamurthy, Robert W. Cross, Thomas W. Geisbert, Vineet Menachery, Kumari Lokugamage, Viktoriya Borisevich, Iliana Lanz, Lisa Anderson, Payal Sipahimalani, Kizzmekia S. Corbett, Eun Sung Yang, Yi Zhang, Wei Shi, Tongqing Zhou, Misook Choe, John Misasi, Peter D. Kwong, Nancy J. Sullivan, Barney S. Graham, Tara L. Fernandez, Carl L. Hansen, Ester Falconer, John R. Mascola, Bryan E. Jones, Bryan C. Barnhart
Publikováno v:
Cell Reports, Vol 39, Iss 7, Pp 110812- (2022)
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-neutralizing monoclonal antibodies (mAbs) can reduce the risk of hospitalization from coronavirus disease 2019 (COVID-19) when administered early. However, SARS-CoV-2 variants of c
Externí odkaz:
https://doaj.org/article/daeff3ff2f814504a3643f35bb419fcf