Výsledky vyhledávání - "Mismatch repair complex"

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FAN1 controls mismatch repair complex assembly via MLH1 retention to stabilize CAG repeat expansion in Huntington's disease

Autor: Alessandro A. Sartori, Gabriel Balmus, Gillian P. Bates, Konstantinos Thalassinos, Hilary Wilkinson, Joseph Hamilton, Michael Flower, Robert Goold, Emma L. Bunting, Antonio Porro, Sarah G. Aldous, Thomas Menneteau, Jose R. Vicente, Sarah J. Tabrizi, Nicholas D. Allen

Publikováno v: Cell Reports

Summary CAG repeat expansion in the HTT gene drives Huntington’s disease (HD) pathogenesis and is modulated by DNA damage repair pathways. In this context, the interaction between FAN1, a DNA-structure-specific nuclease, and MLH1, member of the DNA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4912e55345ce3c5f611a397cc26a6471

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Mismatch repair deficiency predicts response to HER2 blockade in HER2-negative breast cancer

Autor: Shunqiang Li, Sinem Seker, Vaishnavi Devarakonda, Tina Primeau, Svasti Haricharan, Rashi Kalra, Matthew J. Ellis, Nindo Punturi, Aloran Mazumder, Shyam M. Kavuri, Ching-Hui Chen

Publikováno v: Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)

Resistance to endocrine treatment occurs in ~30% of ER+ breast cancer patients resulting in ~40,000 deaths/year in the USA. Preclinical studies strongly implicate activation of growth factor receptor, HER2 in endocrine treatment resistance. However,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95f2beb4ded95dfe7e162fe9756e2c7b
http://europepmc.org/articles/PMC8134423

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Distinct DNA repair pathways cause genomic instability at alternative DNA structures

Autor: Anirban Mukherjee, Jennifer A. McKinney, Karen M. Vasquez, Laura A. Christensen, Guliang Wang, Sai H. Sankara Subramanian, Junhua Zhao

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications

Alternative DNA structure-forming sequences can stimulate mutagenesis and are enriched at mutation hotspots in human cancer genomes, implicating them in disease etiology. However, the mechanisms involved are not well characterized. Here, we discover

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a1b7631e6741509aba4e6938652cb65
https://doi.org/10.1038/s41467-019-13878-9

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GAA•TTC repeat expansion in human cells is mediated by mismatch repair complex MutLγ and depends upon the endonuclease domain in MLH3 isoform one

Autor: Kayla T B Fuselier, Ed Grabczyk, Anasheh Halabi

Publikováno v: Nucleic Acids Research

DNA repeat expansion underlies dozens of progressive neurodegenerative disorders. While the mechanisms driving repeat expansion are not fully understood, increasing evidence suggests a central role for DNA mismatch repair. The mismatch repair recogni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd5d54a1ae785b6b33ad8dc74b97aede
http://europepmc.org/articles/PMC5934671

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Desiccation-induced viable but nonculturable state in Pseudomonas putida KT2440, a survival strategy

Autor: Laura Abisaí Pazos-Rojas, Yolanda Elizabeth Morales-García, Jesús de la Torre, Ligia Catalina Munoz-Arenas, Silvia Luna-Suárez, Osvaldo Rodríguez-Andrade, Lesther Emanuel López-Cruz, Verónica Quintero-Hernández, Jesús Muñoz-Rojas, Miguel Angel Villalobos-López, Antonino Baez, Fábio Lopes-Olivares, Orestes López-Ortega

Publikováno v: PLoS ONE
PLoS ONE, Public Library of Science, 2019, 14 (7), pp.e0219554. ⟨10.1371/journal.pone.0219554⟩
PLoS ONE, Vol 14, Iss 7, p e0219554 (2019)
Digital.CSIC. Repositorio Institucional del CSIC
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The potential of Pseudomonas putida KT2440 to act as a plant-growth promoter or as a bior-emediator of toxic compounds can be affected by desiccation. In the present work, the bacterial survival ratio (BSR) in response to air desiccation was evaluate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85717eaa8bc2fa7e402f256103333d50
http://hdl.handle.net/10261/193117

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Absence of MutSβ leads to the formation of slipped-DNA for CTG/CAG contractions at primate replication forks

Autor: Gagan B. Panigrahi, Arturo López Castel, August B. Pearson, Alan E. Tomkinson, Meghan M. Slean, Christopher E. Pearson

Publikováno v: DNA Repair. 42:107-118

Typically disease-causing CAG/CTG repeats expand, but rare affected families can display high levels of contraction of the expanded repeat amongst offspring. Understanding instability is important since arresting expansions or enhancing contractions

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7602d9378bcb7e2790bfe42a365dfaf8
https://doi.org/10.1016/j.dnarep.2016.04.002

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Dynamic DNA binding licenses a repair factor to bypass roadblocks in search of DNA lesions

Autor: Jennifer A. Surtees, John D. Huck, Ilya J. Finkelstein, Yoori Kim, Gregory M. Williams, Maxwell W. Brown

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Nature Communications

DNA-binding proteins search for specific targets via facilitated diffusion along a crowded genome. However, little is known about how crowded DNA modulates facilitated diffusion and target recognition. Here we use DNA curtains and single-molecule flu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b621773185201d43d2874d86bd798562
https://doaj.org/article/9a3005080b6f41aa9f1b91e79f07cfd2

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Intrinsically disordered regions regulate both catalytic and non-catalytic activities of the MutLα mismatch repair complex

Autor: Christopher M Furman, Eric Alani, Yoori Kim, Ilya J. Finkelstein, Carol M. Manhart

Publikováno v: Nucleic Acids Research

Intrinsically disordered regions (IDRs) are present in at least 30% of the eukaryotic proteome and are enriched in chromatin-associated proteins. Using a combination of genetics, biochemistry, and single-molecule biophysics, we characterize how IDRs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a554c762a7f2528669e34061a638fbfd
https://doi.org/10.1101/475152

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Msh2-Msh3 Interferes with Okazaki Fragment Processing to Promote Trinucleotide Repeat Expansions

Autor: Jennifer A. Surtees, Athena Kantartzis, Lata Balakrishnan, Rick L. Roberts, Gregory M. Williams, Robert A. Bambara

Publikováno v: Cell Reports, Vol 2, Iss 2, Pp 216-222 (2012)

Summary Trinucleotide repeat (TNR) expansions are the underlying cause of more than 40 neurodegenerative and neuromuscular diseases, including myotonic dystrophy and Huntington's disease. Although genetic evidence points to errors in DNA replication

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42a0edd21953257fd1d78458688bd87c
https://doi.org/10.1016/j.celrep.2012.06.020

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