Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Misha Klein"'
Autor:
Behrouz Eslami-Mossallam, Misha Klein, Constantijn V. D. Smagt, Koen V. D. Sanden, Stephen K. Jones, John A. Hawkins, Ilya J. Finkelstein, Martin Depken
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Cas9 off-target sites can be predicted by many bioinformatics tools. Here the authors present low complexity mechanistic model that characterizes SpCas9 kinetics in free-energy terms, allowing quantitative prediction of off-target activity in bulk-bi
Externí odkaz:
https://doaj.org/article/8ce17f4dfe3843928f961470b5546a13
Autor:
Tao Ju Cui, Misha Klein, Jorrit W. Hegge, Stanley D. Chandradoss, John van der Oost, Martin Depken, Chirlmin Joo
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Argonaute protein is loaded with small RNA and scans long stretch of sequences to find complementary target sites. Here, using single-molecule FRET and kinetic modelling, the authors showed that prokaryotic Argonaute protein binds target DNA loosely
Externí odkaz:
https://doaj.org/article/030bdb4c6a084d029bfa423bfee6d58d
Autor:
Michel Gherman, Misha Klein
Publikováno v:
Estudios Sociales del Estado, Vol 5, Iss 9, Pp 101-123 (2019)
Os últimos anos foram de mudanças e transformações no mapa político brasileiro. Se até o ano de 2013 havia um quadro político estabelecido e consolidado no país, a partir desse momento pode-se notar mudanças profundas e sem precedentes no ce
Externí odkaz:
https://doaj.org/article/b7bba40b2a7941a592386856a1fd7c2f
Publikováno v:
Cell Reports, Vol 22, Iss 6, Pp 1413-1423 (2018)
Summary: Due to their specificity, efficiency, and ease of programming, CRISPR-associated nucleases are popular tools for genome editing. On the genomic scale, these nucleases still show considerable off-target activity though, posing a serious obsta
Externí odkaz:
https://doaj.org/article/8930b2f12fd84f7187b4303a1fcd6861
Autor:
Misha Klein
Being Jewish in Brazil--the world's largest Catholic country--is fraught with paradoxes, and living in São Paulo only amplifies these vivid contradictions. The metropolis is home to Jews from over 60 countries of origin, and to the Hebraica, the wor
Autor:
Misha Klein, Subhas C. Bera, Thomas K. Anderson, Bing Wang, Flavia S. Papini, Jamie J. Arnold, Craig E. Cameron, Martin Depken, Robert N. Kirchdoerfer, Irina Artsimovitch, David Dulin
Publikováno v:
Biophysical Journal, 122(3 Supplement 1), 171a-171a. Biophysical Society
Klein, M, Bera, S C, Anderson, T K, Wang, B, Papini, F S, Arnold, J J, Cameron, C E, Depken, M, Kirchdoerfer, R N, Artsimovitch, I & Dulin, D 2023, ' Mechanism of assembly of an elongation-competent SARS-CoV-2 replication transcription complex ', Biophysical Journal, vol. 122, no. 3 Supplement 1, pp. 171a-171a . https://doi.org/10.1016/j.bpj.2022.11.1071
Klein, M, Bera, S C, Anderson, T K, Wang, B, Papini, F S, Arnold, J J, Cameron, C E, Depken, M, Kirchdoerfer, R N, Artsimovitch, I & Dulin, D 2023, ' Mechanism of assembly of an elongation-competent SARS-CoV-2 replication transcription complex ', Biophysical Journal, vol. 122, no. 3 Supplement 1, pp. 171a-171a . https://doi.org/10.1016/j.bpj.2022.11.1071
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fb8339eb4a500aacda2e6045c01b27b
https://research.vu.nl/en/publications/b815bc2f-c880-41dc-a5f6-3840c02196a0
https://research.vu.nl/en/publications/b815bc2f-c880-41dc-a5f6-3840c02196a0
Autor:
Misha Klein
Publikováno v:
World Literature Today. 97:90-91
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca80490055d507928f70fa2932e58b11
https://doi.org/10.1353/wlt.2023.0155
https://doi.org/10.1353/wlt.2023.0155
From beacon to siren: the transformation of Brazil from racial utopia to racist/antisemitic dystopia
Autor:
Michel Gherman, Misha Klein
Publikováno v:
Revista Videre. 13
Neste artigo, oferecemos reflexões sobre o significado dos usos de símbolos judaicos, israelenses e sionistas no contexto político contemporâneo brasileiro. Nesse contexto pretendemos também explorar os significados do aparecimento destes símbo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7896153fe8c7a3f0662a8522c3fbde4b
https://doi.org/10.30612/videre.v13i28.15413
https://doi.org/10.30612/videre.v13i28.15413
Autor:
Misha Klein, Michel Gherman
Publikováno v:
RepHipUNR (UNR)
Universidad Nacional de Rosario
instacron:UNR
Estudios Sociales del Estado, Vol 5, Iss 9, Pp 101-123 (2019)
Universidad Nacional de Rosario
instacron:UNR
Estudios Sociales del Estado, Vol 5, Iss 9, Pp 101-123 (2019)
Os últimos anos foram de mudanças e transformações no mapa político brasileiro. Se até o ano de 2013 havia um quadro político estabelecido e consolidado no país, a partir desse momento pode-se notar mudanças profundas e sem precedentes no ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::721247c9f61198a7dd647b3688c1281e
https://doi.org/10.35305/ese.v5i9.173
https://doi.org/10.35305/ese.v5i9.173
Autor:
Behrouz, Eslami-Mossallam, Misha, Klein, Constantijn V D, Smagt, Koen V D, Sanden, Stephen K, Jones, John A, Hawkins, Ilya J, Finkelstein, Martin, Depken
Publikováno v:
Nature communications. 13(1)
The S. pyogenes (Sp) Cas9 endonuclease is an important gene-editing tool. SpCas9 is directed to target sites based on complementarity to a complexed single-guide RNA (sgRNA). However, SpCas9-sgRNA also binds and cleaves genomic off-targets with only
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7269eec35d9cd050cb723c30b22dead2
https://pubmed.ncbi.nlm.nih.gov/35292641
https://pubmed.ncbi.nlm.nih.gov/35292641