Zobrazeno 1 - 10
of 1 352
pro vyhledávání: '"Misfolded proteins"'
Autor:
Anuran Bhattacharya, Urmi Chatterji
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Cancer stem cells (CSCs), the master regulators of tumor heterogeneity and progression, exert profound influence on cancer metastasis, via various secretory vesicles. Emerging from CSCs, the exosomes serve as pivotal mediators of intercellul
Externí odkaz:
https://doaj.org/article/83bc24fae53e44459a035dab2245912c
Autor:
Oliwia Koszła, Przemysław Sołek
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-23 (2024)
Abstract The primary challenge in today’s world of neuroscience is the search for new therapeutic possibilities for neurodegenerative disease. Central to these disorders lies among other factors, the aberrant folding, aggregation, and accumulation
Externí odkaz:
https://doaj.org/article/decd79ac91bf42d9af4d437c2b88473e
Publikováno v:
Journal of Biomedical Science, Vol 31, Iss 1, Pp 1-24 (2024)
Abstract The endoplasmic reticulum (ER) employs stringent quality control mechanisms to ensure the integrity of protein folding, allowing only properly folded, processed and assembled proteins to exit the ER and reach their functional destinations. M
Externí odkaz:
https://doaj.org/article/2bc3777e54c54136842c2c31e079c86f
Publikováno v:
Frontiers in Marine Science, Vol 11 (2024)
Studying the effect of heating rate on upper thermal limit has gained considerable attention in enhancing our mechanistic understanding of how organisms respond to changing temperatures in the context of climate change. The present study aimed to inv
Externí odkaz:
https://doaj.org/article/7118c3a242e34b7389cdbfad725e644e
Autor:
Dayuan Wang, Xiao Gu, Xinyi Ma, Jun Chen, Qizhi Zhang, Zhihua Yu, Juan Li, Meng Hu, Xiaofang Tan, Yuyun Tang, Jianrong Xu, Minjun Xu, Qingxiang Song, Huahua Song, Gan Jiang, Zaiming Tang, Xiaoling Gao, Hongzhuan Chen
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 2, Pp 834-851 (2023)
Microglial surveillance plays an essential role in clearing misfolded proteins such as amyloid-beta, tau, and α-synuclein aggregates in neurodegenerative diseases. However, due to the complex structure and ambiguous pathogenic species of the misfold
Externí odkaz:
https://doaj.org/article/68830f1934e244a9a3427fb520505ffc
Akademický článek
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Autor:
Manoj Govindarajulu, Sindhu Ramesh, Tharanth Shankar, Murali Krishna Kora, Timothy Moore, Muralikrishnan Dhanasekaran
Publikováno v:
NeuroSci, Vol 3, Iss 4, Pp 533-545 (2022)
Neurodegenerative diseases are characterized by progressive loss of neurons in specific regions of the brain. Neuronal death is often associated with the accumulation of misfolded proteins due to genetic mutations or abnormal protein homeostasis. An
Externí odkaz:
https://doaj.org/article/0e215285fa8c451d9551a9a09333f97b
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Externí odkaz:
https://doaj.org/article/16ee12fcb69541428b901a9502c3a49d
Autor:
Anna Picca, Flora Guerra, Riccardo Calvani, Hélio José Coelho-Junior, Cecilia Bucci, Emanuele Marzetti
Publikováno v:
Neural Regeneration Research, Vol 17, Iss 3, Pp 534-542 (2022)
Extracellular vesicles have been identified as pivotal mediators of intercellular communication with critical roles in physiological and pathological conditions. Via this route, several molecules (e.g., nucleic acids, proteins, metabolites) can be tr
Externí odkaz:
https://doaj.org/article/c29c87aeb20f4aa4ba3e6ed4569af17d
Akademický článek
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