Zobrazeno 1 - 10
of 835
pro vyhledávání: '"Mischel P"'
Autor:
Mio Harachi, Kenta Masui, Erika Shimizu, Kumiko Murakami, Hiromi Onizuka, Yoshihiro Muragaki, Takakazu Kawamata, Hisako Nakayama, Mariko Miyata, Takashi Komori, Webster K. Cavenee, Paul S. Mischel, Atsushi Kurata, Noriyuki Shibata
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-17 (2024)
Abstract DNA methylation is crucial for chromatin structure and gene expression and its aberrancies, including the global “hypomethylator phenotype”, are associated with cancer. Here we show that an underlying mechanism for this phenotype in the
Externí odkaz:
https://doaj.org/article/59ba976a12834ee782df85c5cc6333ba
Autor:
Gustavo Barbi Vieira, Hévilla Souza Oliveira, Jônatas Araújo de Almeida, Mischel Carmen Neyra Belderrain
Publikováno v:
Project Leadership and Society, Vol 5, Iss , Pp 100115- (2024)
Project Portfolio Selection (PPS) is a relevant activity in organizations to define the best set of projects to pursue their strategic objectives. Previous works have presented diverse and sometimes conflicting understandings of the meaning and impli
Externí odkaz:
https://doaj.org/article/184a822598ad4762bf74399413122ee4
Autor:
Miin S Lin, Se-Young Jo, Jens Luebeck, Howard Y Chang, Sihan Wu, Paul S Mischel, Vineet Bafna
Publikováno v:
eLife, Vol 12 (2024)
Extrachromosomal DNA is a common cause of oncogene amplification in cancer. The non-chromosomal inheritance of ecDNA enables tumors to rapidly evolve, contributing to treatment resistance and poor outcome for patients. The transcriptional context in
Externí odkaz:
https://doaj.org/article/046c3f6729814f22a71b2d46f9439236
Autor:
Jamarie Geller, Katherine Keith, Christian Smith, Rachel Pacilio, Cynthia Arfken, Megan Oxley, Nicholas Mischel
Publikováno v:
Journal of Affective Disorders Reports, Vol 15, Iss , Pp 100688- (2024)
Background: Ketamine has demonstrated efficacy in treating depression unresponsive to traditional interventions and is increasingly utilized in psychiatric practice. However, limited information is available regarding effectiveness in patients with p
Externí odkaz:
https://doaj.org/article/35579162de3e497dba943e057ecbc451
Autor:
Recio Juan A, Glaspy John A, Ng Charles, Sazegar Hooman, Matsunaga Doug, Guo Deliang, Attar Narsis, von Euw Erika, Niehr Franziska, Lo Roger S, Mischel Paul S, Comin-Anduix Begonya, Ribas Antoni
Publikováno v:
Journal of Translational Medicine, Vol 9, Iss 1, p 76 (2011)
Abstract Background A molecular linkage between the MAPK and the LKB1-AMPK energy sensor pathways suggests that combined MAPK oncogene inhibition and metabolic modulation of AMPK would be more effective than either manipulation alone in melanoma cell
Externí odkaz:
https://doaj.org/article/07f1a3c842bf4d638c59891157f0e629
Autor:
Kehoe Sarah M, Barretina Jordi G, MacConaill Laura E, Sazegar Hooman, Mok Stephen, Hsueh Teli, Guo Deliang, Wang Qi, Nazarian Ramin, Søndergaard Jonas N, Attar Narsis, von Euw Erika, Zuckerman Jonathan E, Chmielowski Bartosz, Comin-Anduix Begoña, Koya Richard C, Mischel Paul S, Lo Roger S, Ribas Antoni
Publikováno v:
Journal of Translational Medicine, Vol 8, Iss 1, p 39 (2010)
Abstract Blocking oncogenic signaling induced by the BRAFV600E mutation is a promising approach for melanoma treatment. We tested the anti-tumor effects of a specific inhibitor of Raf protein kinases, PLX4032/RG7204, in melanoma cell lines. PLX4032 d
Externí odkaz:
https://doaj.org/article/6fff43b663ca40a9a338bc0bb035ebf6
Autor:
Farooqi Haumith K, Liau Linda M, Dong Jun, Lai Albert, Cloughesy Timothy F, Scheck Adrienne C, Lee Yohan, Horvath Steve, Mischel Paul S, Nelson Stanley F
Publikováno v:
BMC Medical Genomics, Vol 1, Iss 1, p 52 (2008)
Abstract Background Glioblastomas are the most common primary brain tumour in adults. While the prognosis for patients is poor, gene expression profiling has detected signatures that can sub-classify GBMs relative to histopathology and clinical varia
Externí odkaz:
https://doaj.org/article/267a91296f0440d1a0c3381f9b5099f1
Publikováno v:
BMC Genomics, Vol 7, Iss 1, p 40 (2006)
Abstract Background Genes and proteins are organized into functional modular networks in which the network context of a gene or protein has implications for cellular function. Highly connected hub proteins, largely responsible for maintaining network
Externí odkaz:
https://doaj.org/article/9bcaf2c86bbf4cd48373a9efb22d7b58
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.