Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Mischa R. Müller"'
Autor:
Emelie Foord, Charlotte Klynning, Esther Schoutrop, Judith M. Förster, Jennifer Krieg, Anette Mörtberg, Mischa R. Müller, Christel Herzog, Dieter Schiegg, Denis Villemagne, Ulrike Fiedler, Dan Snell, Benjamin Kebble, Jonas Mattsson, Victor Levitsky, Michael Uhlin
Publikováno v:
Journal of Immunology Research, Vol 2020 (2020)
PD-1/PD-L1 blockade has revolutionized the field of immunooncology. Despite the relative success, the response rate to anti-PD-1 therapy requires further improvements. Our aim was to explore the enhancement of T-cell function by using novel PD-1-bloc
Externí odkaz:
https://doaj.org/article/1b8abe36663a4d659c3c6bc13e5ba077
Autor:
John Steven, Mischa R. Müller, Miguel F. Carvalho, Obinna C. Ubah, Marina Kovaleva, Gerard Donohoe, Thomas Baddeley, Dawn Cornock, Kenneth Saunders, Andrew J. Porter, Caroline Jane Barelle
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Molecular engineering to increase the percentage identity to common human immunoglobulin sequences of non-human therapeutic antibodies and scaffolds has become standard practice. This strategy is often used to reduce undesirable immunogenic responses
Externí odkaz:
https://doaj.org/article/7110d669fa544afe8fc82b08c6045dd8
Autor:
William S. Somers, Daniel King, Adarsh Godbole, Lidia Mosyak, Oleg V. Kovalenko, Valerie Calabro, Lioudmila Tchistiakova, Caroline J. Barelle, Nicole Piche-Nicholas, Kristine Svenson, Mischa R. Müller, Davinder Gill, Andrea Olland
Publikováno v:
Journal of Biological Chemistry. 288:17408-17419
The immunoglobulin new antigen receptors (IgNARs) are a class of Ig-like molecules of the shark immune system that exist as heavy chain-only homodimers and bind antigens by their single domain variable regions (V-NARs). Following shark immunization a
Autor:
Allan Jensen, Christopher Grace, Nicole Piche-Nicholas, Timothy P. Hickling, Lam Khetemenee, Stephane Olland, John Steven, Ronan O’Dwyer, Lioudmila Tchistiakova, Macy Jin, Yulia Vugmeyster, Caroline J. Barelle, Leeying Wu, Mischa R. Müller, Davinder Gill, Kenneth Saunders
Publikováno v:
mAbs. 4:673-685
Advances in recombinant antibody technology and protein engineering have provided the opportunity to reduce antibodies to their smallest binding domain components and have concomitantly driven the requirement for devising strategies to increase serum
Autor:
Stuart D. Perkins, Oliver J. Lanning, Sarah A. Goodchild, John Steven, Christopher H. Logue, Riccardo V. D'Elia, Robert J. Phillpotts, Mischa R. Müller, Lyn M. O’Brien
Publikováno v:
Antiviral Research. 90:1-8
In murine models of Venezuelan equine encephalitis virus (VEEV) infection, the neutralising monoclonal antibody 1A3B-7 has been shown to be effective in passive protection from challenge by the aerosol route with serogroups I, II and Mucambo virus (f
Autor:
Marina Kovaleva, Ronan O’Dwyer, Caroline J. Barelle, Helen Dooley, Fiona M. Rudkin, Mischa R. Müller
Publikováno v:
Antibody Engineering ISBN: 9781617799730
The drive to exploit novel targets and biological pathways has lead to the expansion of classical antibody research into innovative fragment adaptations and novel scaffolds. The hope being that alternative or cryptic epitopes may be targeted, tissue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44739a6eddba967b092e8bc91bb33e5e
https://doi.org/10.1007/978-1-61779-974-7_9
https://doi.org/10.1007/978-1-61779-974-7_9
Autor:
Musen Liang, Kathryn Crouch, Martin F. Flajnik, Lauren E. Smith, John Steven, Helen Dooley, Wei Cao, Caroline J. Barelle, Leeying Wu, Mischa R. Müller, Davinder Gill, Heather H. Shih, Janet E. Paulsen, Mike Lee
Publikováno v:
Developmental and comparative immunology. 36(4)
The cartilaginous fish (chimeras, sharks, skates and rays) are the oldest group relative to mammals in which an adaptive immune system founded upon immunoglobulins has been found. In this manuscript we characterize the immunoglobulins of the spiny do
Autor:
William J.J. Finlay, Brian J. Fennell, S.E. Hufton, Mischa R. Müller, Davinder Gill, Orla Cunningham, Valerie Calabro, Leeying Wu, Wei Cao, Alfredo Darmanin-Sheehan
Publikováno v:
Journal of molecular biology. 400(2)
The shark antigen-binding V(NAR) domain has the potential to provide an attractive alternative to traditional biotherapeutics based on its small size, advantageous physiochemical properties, and unusual ability to target clefts in enzymes or cell sur