Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Misbha, Ud Din Ahmad"'
Autor:
Christopher R. Smith, Svitlana Kulyk, Misbha Ud Din Ahmad, Valentina Arkhipova, James G. Christensen, Robin J. Gunn, Anthony Ivetac, John M. Ketcham, Jon Kuehler, J. David Lawson, Nicole C. Thomas, Xiaolun Wang, Matthew A. Marx
Publikováno v:
RSC Medicinal Chemistry. 13:1549-1564
Herein we describe our approach to prioritize five fragment hits with the objective of answering three questions: could the binding potency be improved? Were the series chemically tractable? Could additional co-crystal structures be solved?
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8c927f9ba7684ab99a67e20faf2bf6f
https://doi.org/10.1039/d2md00163b
https://doi.org/10.1039/d2md00163b
Autor:
Andrea Musacchio, Anastassis Perrakis, Andrew P. Carter, Ingrid R. Vetter, Petra Janning, Stefano Maffini, Andreas Brockmeyer, Sabine Wohlgemuth, Franziska Müller, Mathias Girbig, Verena Cmentowski, Misbha Ud Din Ahmad, Ennio d’Amico
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e551c1bd02298fdd62f2c5616f1733d1
https://doi.org/10.15252/rc.2022086323
https://doi.org/10.15252/rc.2022086323
Autor:
Sebastian Wierer, Peter Daldrop, Misbha Ud Din Ahmad, Winfried Boos, Malte Drescher, Wolfram Welte, Ralf Seidel
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0156098 (2016)
In many hyperthermophilic archaea the DNA binding protein TrmBL2 or one of its homologues is abundantly expressed. TrmBL2 is thought to play a significant role in modulating the chromatin architecture in combination with the archaeal histone proteins
Externí odkaz:
https://doaj.org/article/77375a604eeb46148a7f2ac69eead533
Autor:
Ennio d’Amico, Misbha Ud Din Ahmad, Verena Cmentowski, Mathias Girbig, Franziska Müller, Sabine Wohlgemuth, Andreas Brockmeyer, Stefano Maffini, Petra Janning, Ingrid R. Vetter, Andrew P. Carter, Anastassis Perrakis, Andrea Musacchio
Cytoplasmic Dynein 1, or Dynein, is a microtubule minus-end directed motor. Dynein motility requires Dynactin and a family of activating adaptors that stabilize the Dynein-Dynactin complex and promote regulated interactions with cargo in space and ti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3c57b59edc06a918b8cf7147df66531
https://www.biorxiv.org/content/10.1101/2022.02.02.478874v1
https://www.biorxiv.org/content/10.1101/2022.02.02.478874v1
Autor:
Ennio A. d’Amico, Misbha Ud Din Ahmad, Verena Cmentowski, Mathias Girbig, Franziska Müller, Sabine Wohlgemuth, Andreas Brockmeyer, Stefano Maffini, Petra Janning, Ingrid R. Vetter, Andrew P. Carter, Anastassis Perrakis, Andrea Musacchio
Cytoplasmic Dynein 1, or Dynein, is a microtubule minus end–directed motor. Dynein motility requires Dynactin and a family of activating adaptors that stabilize the Dynein–Dynactin complex and promote regulated interactions with cargo in space an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::556c814b9397f9e60383deb350840660
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85137935918
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85137935918
Autor:
Ralphe Drenth, Misbha Ud Din Ahmad, Wouter Elings, Monika Timmer, Anneloes Blok, Danny B. van Zanten, Marcellus Ubbink, Anastassis Perrakis, Aleksandra Chikunova
Publikováno v:
Antimicrobial Agents and Chemotherapy
Antimicrobial Agents and Chemotherapy, 65(8), e02628-20. American Society for Microbiology
Antimicrobial Agents and Chemotherapy, 65(8), e02628-20. American Society for Microbiology
The β-lactamase of Mycobacterium tuberculosis, BlaC, is susceptible to inhibition by clavulanic acid. The ability of this enzyme to escape inhibition through mutation was probed using error-prone PCR combined with functional screening in Escherichia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3be53aee75258d437ccd1fccea1004cb
https://doi.org/10.1128/aac.02628-20
https://doi.org/10.1128/aac.02628-20
Autor:
Aleksandra Chikunova, Misbha Ud Din Ahmad, Adil A Safeer, Marcellus Ubbink, Anastassis Perrakis, Ilona van Alen
Publikováno v:
Biochemistry, 60(28), 2236-2245. American Chemical Society (ACS)
Biochemistry
Biochemistry
The current rise of antibiotic resistant forms of Mycobacterium tuberculosis is a global health threat that calls for new antibiotics. The β-lactamase BlaC of this pathogen prevents the use of β-lactam antibiotics, except in combination with a β-l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6f5037926d148ff1997ec9650d55178
https://hdl.handle.net/1887/3245475
https://hdl.handle.net/1887/3245475
Autor:
Jeroen Molenaar, Alexander Fish, Sridhar Sreeramulu, Harald Schwalbe, Nadide Altincekic, Misbha Ud Din Ahmad, Christian Richter, Hans Wienk, Anastassis Perrakis
Publikováno v:
Journal of Visualized Experiments
Thermal shift assays (TSAs) examine how the melting temperature (Tm) of a target protein changes in response to changes in its environment (e.g., buffer composition). The utility of TSA, and specifically of nano-Differential Scanning Fluorimetry (nan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ad6d16804c0a0ffe66fc611200fecc0
https://doi.org/10.3791/62469-v
https://doi.org/10.3791/62469-v
Autor:
Anastassis Perrakis, Misbha Ud Din Ahmad, Max P. Manley, Tuğçe Bilman, Aleksandra Chikunova, Marcellus Ubbink
Publikováno v:
The Febs Journal
FEBS Journal, 288(19), 5708-5722. Wiley
'FEBS Journal ', vol: 288, pages: 5708-5722 (2021)
FEBS Journal, 288(19), 5708-5722. Wiley
'FEBS Journal ', vol: 288, pages: 5708-5722 (2021)
Evolutionary robustness requires that the number of highly conserved amino acid residues in proteins is minimized. In enzymes, such conservation is observed for catalytic residues but also for some residues in the second shell or even further from th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50d917061cfb2556f3f5db8681d18906
https://hdl.handle.net/1887/3245477
https://hdl.handle.net/1887/3245477