Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Misato Takashima-Hirano"'
Autor:
Chika Watanabe, Hisashi Doi, Hiroko Koyama, Hideki Ishii, Misato Takashima-Hirano, Masaaki Suzuki, Kengo Sumi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:3622-3625
Retinoids are a class of chemical compounds which include both natural dietary vitamin A (retinol) metabolites and active synthetic analogs. Both experimental and clinical studies have revealed that retinoids regulate a wide variety of essential biol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f3caecf6d78494ddcb611594c362569
https://doi.org/10.1016/j.bmcl.2014.05.041
https://doi.org/10.1016/j.bmcl.2014.05.041
Autor:
Chunyong Wu, Hiroyuki Kusuhara, Yumiko Katayama, Masaaki Suzuki, Yuichi Sugiyama, Yasuyoshi Watanabe, Misato Takashima-Hirano, Yasuhiro Wada, Tadayuki Takashima
Publikováno v:
Journal of Nuclear Medicine. 54:267-276
A quantitative PET imaging method was used to assess the in vivo kinetics of hepatobiliary and renal excretion of the breast cancer resistance protein (Bcrp) substrate 11C-SC-62807 in mice. Methods: Serial abdominal PET scans were collected in wild-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c3727cbeaaca2da377cbf4ce2ab990b
https://doi.org/10.2967/jnumed.112.110254
https://doi.org/10.2967/jnumed.112.110254
Autor:
Masaaki Suzuki, Hiroko Koyama, Misato Takashima-Hirano, Takafumi Yamaoka, Hisashi Doi, Hiroyoshi Hidaka, Hiroko Nagata, Kengo Sumi
Publikováno v:
Tetrahedron. 68:2336-2341
A novel PET probe, [11C]H-1152, specific for Rho-kinases, was synthesized efficiently for the first time based on rapid Pd0-mediated C-[11C]methylation using [11C]methyl iodide and a tributylstannyl precursor, giving the isolated radioactivity of 3.8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f2b60a9b868012ab635fad229fea777
https://doi.org/10.1016/j.tet.2012.01.033
https://doi.org/10.1016/j.tet.2012.01.033
Autor:
Kiyoshi Matsumura, Yasuyoshi Watanabe, Tadayuki Takashima, Masaaki Suzuki, Osamu Inoue, Keiko Tokuda, Hirotaka Onoe, Misato Takashima-Hirano, Miho Shukuri, Hisashi Doi
Publikováno v:
Journal of Nuclear Medicine. 52:1094-1101
Cyclooxygenase (COX)-1 and -2 are prostanoid-synthesizing enzymes that play important roles in the regulation of neuroinflammation and in the development of neurodegenerative disorders. However, the specific functions of these isoforms are still uncl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2eca113b3746e7900d559b911ff91ae
https://doi.org/10.2967/jnumed.110.084046
https://doi.org/10.2967/jnumed.110.084046
Autor:
Miho Shukuri, Hisashi Doi, Misato Takashima-Hirano, Masaaki Suzuki, Yasuyoshi Watanabe, Miki Goto, Hirotaka Onoe, Yasuhiro Wada, Tadayuki Takashima
Publikováno v:
Chemistry - A European Journal. 16:4250-4258
Cyclooxygenase (COX) is a critical enzyme in prostaglandin biosynthesis that modulates a wide range of biological functions, such as pain, fever, and so on. To perform in vivo COX imaging by positron emission tomography (PET), we developed a method t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aa37a8a545552092352cfbbcad09ef2
https://doi.org/10.1002/chem.200903044
https://doi.org/10.1002/chem.200903044
Autor:
Masaaki Suzuki, Hisashi Doi, Takamitsu Hosoya, Hiroko Koyama, Siqin, Kengo Sumi, Misato Takashima-Hirano
Publikováno v:
Chemistry - A European Journal. 15:12489-12495
The Pd(0)-mediated rapid trapping of methyl iodide with an excess amount of a heteroaryl-substituted tributylstannane has been investigated with the aim of incorporating a short-lived (11)C-labelled methyl group into the heteroaromatic carbon framewo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b43f3b815cdb0628c19ad43b9a088d61
https://doi.org/10.1002/chem.200901145
https://doi.org/10.1002/chem.200901145
Autor:
Hirotaka Onoe, Yasuhisa Tamura, Tadayuki Takashima, Yasuhiro Wada, Yasuyoshi Watanabe, Miho Shukuri, Yilong Cui, Yosky Kataoka, Hisashi Doi, Misato Takashima-Hirano
Publikováno v:
Journal of Nuclear Medicine. 50:1904-1911
Neurogenic inflammation triggered by extravasation of plasma protein has been hypothesized as a key factor in the generation of the pain sensation associated with migraine. The principal immune cell that responds to this inflammation is the parenchym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::077b85ebe540410a35f1673261db11d2
https://doi.org/10.2967/jnumed.109.066498
https://doi.org/10.2967/jnumed.109.066498
Publikováno v:
Chemical and Pharmaceutical Bulletin. 59:1062-1064
Ramelteon (TAK-375) is a novel melatonin receptor agonist that is used for clinical treatment of insomnia. The present report describes radiolabeling of ramelteon with the short-lived positron-emitter 11C (T1/2=20.4 min) by 2 methods. One method was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90b082fd81d6537d00cdc8349c9b61cd
https://doi.org/10.1248/cpb.59.1062
https://doi.org/10.1248/cpb.59.1062
Publikováno v:
Positron Emission Tomography-Current Clinical and Research Aspects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbf1e189cabc3ea995dec7a34e3b622f
http://www.intechopen.com/articles/show/title/pd0-mediated-rapid-c-11c-methylation-and-c-18f-fluoromethylation-revolutionary-advanced-methods-for-
http://www.intechopen.com/articles/show/title/pd0-mediated-rapid-c-11c-methylation-and-c-18f-fluoromethylation-revolutionary-advanced-methods-for-
Autor:
Misato, Takashima-Hirano, Syusaku, Tazawa, Kazuhiro, Takahashi, Hisashi, Doi, Masaaki, Suzuki
Publikováno v:
Chemicalpharmaceutical bulletin. 59(8)
Ramelteon (TAK-375) is a novel melatonin receptor agonist that is used for clinical treatment of insomnia. The present report describes radiolabeling of ramelteon with the short-lived positron-emitter ¹¹C (T(1/2)=20.4 min) by 2 methods. One method
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::26ade7d4425c08433140c413795fc31d
https://pubmed.ncbi.nlm.nih.gov/21804256
https://pubmed.ncbi.nlm.nih.gov/21804256