Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Misato Funayama"'
Autor:
Takayuki Kondo, Keiko Imamura, Misato Funayama, Kayoko Tsukita, Michiyo Miyake, Akira Ohta, Knut Woltjen, Masato Nakagawa, Takashi Asada, Tetsuaki Arai, Shinobu Kawakatsu, Yuishin Izumi, Ryuji Kaji, Nobuhisa Iwata, Haruhisa Inoue
Publikováno v:
Cell Reports, Vol 21, Iss 8, Pp 2304-2312 (2017)
In the process of drug development, in vitro studies do not always adequately predict human-specific drug responsiveness in clinical trials. Here, we applied the advantage of human iPSC-derived neurons, which offer human-specific drug responsiveness,
Externí odkaz:
https://doaj.org/article/119fc43eb23c46f4bc742a11a0c112de
Autor:
Shin-ichiro Sekine, Takayuki Kondo, Nagahisa Murakami, Keiko Imamura, Takako Enami, Ran Shibukawa, Kayoko Tsukita, Misato Funayama, Masatoshi Inden, Hisaka Kurita, Isao Hozumi, Haruhisa Inoue
Publikováno v:
Stem Cell Research, Vol 24, Iss C, Pp 40-43 (2017)
Idiopathic basal ganglia calcification (IBGC), also known as Fahr disease or primary familial brain calcifications (PFBC), is a rare neurodegenerative disorder characterized by calcium deposits in basal ganglia and other brain regions, causing neurop
Externí odkaz:
https://doaj.org/article/ca83311820a143458bf3559849bcf6a0
Autor:
Ghee Wan Tan, Takayuki Kondo, Nagahisa Murakami, Keiko Imamura, Takako Enami, Kayoko Tsukita, Ran Shibukawa, Misato Funayama, Riki Matsumoto, Akio Ikeda, Ryosuke Takahashi, Haruhisa Inoue
Publikováno v:
Stem Cell Research, Vol 24, Iss C, Pp 12-15 (2017)
Autosomal dominant lateral temporal epilepsy (ADLTE) is an inherited epileptic syndrome, and it is associated with mutations of leucine-rich glioma inactivated 1 (LGI1) gene. The underlying mechanisms of ADLTE are still unknown, as human neurons are
Externí odkaz:
https://doaj.org/article/96515e19ee224a44a8a87cc42c86e5d6
Autor:
Nagahisa Murakami, Taizo Ishikawa, Takayuki Kondo, Keiko Imamura, Kayoko Tsukita, Takako Enami, Misato Funayama, Ran Shibukawa, Shinichi Matsumoto, Yuishin Izumi, Etsuro Ohta, Fumiya Obata, Ryuji Kaji, Haruhisa Inoue
Publikováno v:
Stem Cell Research, Vol 24, Iss C, Pp 36-39 (2017)
Peripheral blood mononuclear cells (PBMCs) were collected from a clinically diagnosed 20-year-old dystonia patient with a GCH1 mutation (DYT5). Episomal vectors were used to introduce reprogramming factors (OCT3/4, SOX2, KLF4, L-MYC, LIN28, and p53 c
Externí odkaz:
https://doaj.org/article/3c60341b2ff94882ac8bb71a9bfad8db
Autor:
Takayuki Kondo, Misato Funayama, Kayoko Tsukita, Akitsu Hotta, Akimasa Yasuda, Satoshi Nori, Shinjiro Kaneko, Masaya Nakamura, Ryosuke Takahashi, Hideyuki Okano, Shinya Yamanaka, Haruhisa Inoue
Publikováno v:
Stem Cell Reports, Vol 3, Iss 2, Pp 242-249 (2014)
Transplantation of glial-rich neural progenitors has been demonstrated to attenuate motor neuron degeneration and disease progression in rodent models of mutant superoxide dismutase 1 (SOD1)-mediated amyotrophic lateral sclerosis (ALS). However, tran
Externí odkaz:
https://doaj.org/article/4886217ee1b340a088e2fdcae6c35335
Autor:
Keiko Imamura, Masato Nakagawa, Takayuki Kondo, Nobuhisa Iwata, Haruhisa Inoue, Michiyo Miyake, Akira Ohta, Takashi Asada, Shinobu Kawakatsu, Yuishin Izumi, Misato Funayama, Ryuji Kaji, Kayoko Tsukita, Knut Woltjen, Tetsuaki Arai
Publikováno v:
Cell Reports, Vol 21, Iss 8, Pp 2304-2312 (2017)
In the process of drug development, in vitro studies do not always adequately predict human-specific drug responsiveness in clinical trials. Here, we applied the advantage of human iPSC-derived neurons, which offer human-specific drug responsiveness,
Autor:
Nagahisa Murakami, Takako Enami, Hisaka Kurita, Misato Funayama, Keiko Imamura, Shin-ichiro Sekine, Ran Shibukawa, Takayuki Kondo, Masatoshi Inden, Isao Hozumi, Kayoko Tsukita, Haruhisa Inoue
Publikováno v:
Stem Cell Research, Vol 24, Iss C, Pp 40-43 (2017)
Idiopathic basal ganglia calcification (IBGC), also known as Fahr disease or primary familial brain calcifications (PFBC), is a rare neurodegenerative disorder characterized by calcium deposits in basal ganglia and other brain regions, causing neurop
Autor:
Nagahisa Murakami, Kayoko Tsukita, Ran Shibukawa, Takayuki Kondo, Akio Ikeda, Takako Enami, Ghee Wan Tan, Haruhisa Inoue, Keiko Imamura, Misato Funayama, Riki Matsumoto, Ryosuke Takahashi
Publikováno v:
Stem Cell Research, Vol 24, Iss C, Pp 12-15 (2017)
Autosomal dominant lateral temporal epilepsy (ADLTE) is an inherited epileptic syndrome, and it is associated with mutations of leucine-rich glioma inactivated 1 (LGI1) gene. The underlying mechanisms of ADLTE are still unknown, as human neurons are
Autor:
Takayuki Kondo1, Misato Funayama1, Michiyo Miyake1, Kayoko Tsukita1, Takumi Era2, Hitoshi Osaka3, Takashi Ayaki4, Ryosuke Takahashi4, Haruhisa Inoue1 haruhisa@cira.kyoto-u.ac.jp
Publikováno v:
Acta Neuropathologica Communications. 7/11/2016, Vol. 4, p1-12. 12p.
Autor:
Akitsu Hotta, Shinya Yamanaka, Ryosuke Takahashi, Satoshi Nori, Akimasa Yasuda, Shinjiro Kaneko, Masaya Nakamura, Haruhisa Inoue, Hideyuki Okano, Kayoko Tsukita, Misato Funayama, Takayuki Kondo
Publikováno v:
Stem Cell Reports, Vol 3, Iss 2, Pp 242-249 (2014)
Stem Cell Reports
Stem Cell Reports
Summary Transplantation of glial-rich neural progenitors has been demonstrated to attenuate motor neuron degeneration and disease progression in rodent models of mutant superoxide dismutase 1 (SOD1)-mediated amyotrophic lateral sclerosis (ALS). Howev