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Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance

Autor: Masaaki Toda, Misako Itoh, Takashi Nomura, Noriko Sakaguchi, Jun Shimizu, Takeshi Takahashi, Sayuri Yamazaki, Yuhshi Kuniyasu, Shimon Sakaguchi, Toshiko Sakihama

Publikováno v: Immunological Reviews. 182:18-32

There is accumulating evidence that T-cell-mediated dominant control of self-reactive T-cells contributes to the maintenance of immunologic self-tolerance and its alteration can cause autoimmune disease. Efforts to delineate such a regulatory T-cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0364f8114a77ca6b41ef71248806edf6
https://doi.org/10.1034/j.1600-065x.2001.1820102.x

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Hidradenoma Papilliferum. A Case Report and Immunohistochemical Study

Autor: Fujio Otsuka, Yoshihiro Umebayashi, Misako Itoh, Takeshi Tateishi

Publikováno v: Nishi Nihon Hifuka. 57:251-254

Hidradenoma papilliferumは中年女性の外陰部に好発するアポクリン汗器官由来の良性腫瘍で, 本邦皮膚科領域での報告は比較的まれである。われわれは43歳の女性の外陰部に生じた本症の1例を�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::34e79be3ec7e261dcf47fb550de4fe6f
https://doi.org/10.2336/nishinihonhifu.57.251

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Skin metastasis of prostatic carcinoma.Report of a case and statistical observation of skin metastasis of visceral cancer at Univ. of Tsukuba

Autor: Minoru Hoshino, Mituru Iwata, Misako Itoh, Yoshihiro Umebayashi, Fujio Ohtsuka

Publikováno v: Skin Cancer. 9:212-216

A case of prostatic carcinoma with skin metastases is reported. The patient showed four cutaneous nodules on the head. We biopsied one of them, and found out that it is skin metastases of an adenocarcinoma. After admission to Tsukuba Univ. Department

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6f1d00bc30e41cd20fa862eb77197ab0
https://doi.org/10.5227/skincancer.9.212

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Pillars article: immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 1995

Autor: Shimon, Sakaguchi, Noriko, Sakaguchi, Masanao, Asano, Misako, Itoh, Masaaki, Toda

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 186(7)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2b7c9e3b4e42f418e5b11375291a36f6
https://pubmed.ncbi.nlm.nih.gov/21422251

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Immunologic self tolerance maintained by T-cell-mediated control of self-reactive T cells: implications for autoimmunity and tumor immunity

Autor: Shimon Sakaguchi, Noriko Sakaguchi, Sayuri Yamazaki, Yuhshi Kuniyasu, Misako Itoh, Jun Shimizu, Takeshi Takahashi

Publikováno v: Microbes and infection. 3(11)

T-cell-mediated dominant control of self-reactive T cells is one mechanism for maintaining immunologic self tolerance. It also hampers the generation of immunity to autologous tumor cells. Abrogation of the control can evoke potent tumor immunity as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::463343d67a79f7e3ff86fd1b7dca0ea6
https://pubmed.ncbi.nlm.nih.gov/11564439

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Increased T cell autoreactivity in the absence of CD40-CD40 ligand interactions: a role of CD40 in regulatory T cell development

Autor: Noriko Sakaguchi, Ihn-Sook Lee, Wei Shi, Hitoshi Kikutani, Misako Itoh, Masahito Kamanaka, Chie Watanabe, Shimon Sakaguchi, Atsushi Kumanogoh, Xiaosong Wang, Takehito Sato, Kanji Yoshida, Sonoko Habu

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 166(1)

Mutations in the CD40 ligand (CD40L) gene lead to X-linked immunodeficiency with hyper-IgM, which is often associated with autoimmune diseases. To determine the contribution of defective CD40-CD40L interactions to T cell autoreactivity, we reconstitu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11255b924cee2e7055ebf1e641aff9d5
https://pubmed.ncbi.nlm.nih.gov/11123312

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Naturally anergic and suppressive CD25(+)CD4(+) T cells as a functionally and phenotypically distinct immunoregulatory T cell subpopulation

Autor: Takeshi Takahashi, Misako Itoh, Gotaroh Toda, Jun Shimizu, Shimon Sakaguchi, Yuhshi Kuniyasu

Publikováno v: International immunology. 12(8)

A CD4(+) T cell subpopulation defined by the expression levels of a particular cell surface molecule (e.g. CD5, CD45RB, CD25, CD62L or CD38) bears an autoimmune-preventive activity in various animal models. Here we show that the expression of CD25 is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e9fc2be0ec5cbfa3dc72b83a67fffae
https://pubmed.ncbi.nlm.nih.gov/10917889

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T cell-mediated maintenance of natural self-tolerance: its breakdown as a possible cause of various autoimmune diseases

Autor: Misako Itoh, Shimon Sakaguchi, Masanao Asano, Masaaki Toda, Stephen Morse, Noriko Sakaguchi

Publikováno v: Journal of autoimmunity. 9(2)

This paper shows that elimination of a small subpopulation of peripheral T cells can elicit activation/expansion of self-reactive T cells from the remaining T cells and produce a wide spectrum of organ-specific and systemic auto-immune diseases in no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb361ed1c63256588a568d7f8b23694a
https://pubmed.ncbi.nlm.nih.gov/8738965

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