Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Misaki, Naota"'
Autor:
Aki Fujisaka, Osamu Fueki, Hiroshi Onodera, Takahiro Nakazawa, Kazuto Watanabe, Kiyoshi Kinoshita, Yoko Hirabayashi, Kosuke Ito, Kazushige Maki, Satoshi Obika, Misaki Naota, Mutsumi Suzuki, Teruyo Arato
Publikováno v:
Nucleic Acid Therapeutics
This white paper summarizes the current consensus of the Japanese Research Working Group for the ICH S6 & Related Issues (WGS6) on strategies for the nonclinical safety assessment of oligonucleotide-based therapeutics (ONTs), specifically focused on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcd01f15555dd204ca64bfdf8d1d47b5
https://pubmed.ncbi.nlm.nih.gov/33470890
https://pubmed.ncbi.nlm.nih.gov/33470890
Autor:
Atsushi Watanabe, Norihiro Sato, Hijiri Iwata, Osamu Kusuoka, Hirofumi Hatakeyama, Misaki Naota, Takayuki Anzai, Dai Nakae, Osamu Nakazono, Daniel Potenta, Michael Wasko
Publikováno v:
Journal of Toxicologic Pathology
The Standard for Exchange of Nonclinical Data (SEND), introduced by the US Food and Drug Administration (FDA), is a scheme for the computerization, electronic application, and screening of preclinical data. Since its establishment, related organizati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e72784b3d5ddbd7548b61100fbffe748
https://doi.org/10.1293/tox.2017-0019
https://doi.org/10.1293/tox.2017-0019
Autor:
Akinori Shimada, Takehito Morita, Ken-ichiro Inoue, Misaki Naota, Yoshimi Kobayashi, Yukari Kohara, Hirohisa Takano
Publikováno v:
Folia Histochemica et Cytobiologica. 53:294-306
Introduction. Exposure to Asian sand dust (ASD) is associated with enhanced pulmonary morbidity and mortality, and the reporting of such cases has rapidly increased in East Asia since 2000. The purpose of the study was to assess chronic lung toxici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca0dc16956c147b11fb098e399fa1ed5
https://doi.org/10.5603/fhc.a2015.0030
https://doi.org/10.5603/fhc.a2015.0030
Autor:
Kotaro Miyake, Akinori Shimada, Takehito Morita, Yuko Naya, Kikumi Ogihara, Ken-ichiro Inoue, Hirohisa Takano, Yuri Kenmotsu, Misaki Naota
Publikováno v:
Folia histochemica et cytobiologica. 56(1)
I ntroduction. We have previously reported that Asian sand dust (ASD) induced acute and chronic inflammatory changes in the lung of mice. Zinc (Zn) is reported to influence inflammation and wound healing. The purpose of the study was to assess the ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5313759d3e7b20d2c4f18da6ef85f0d8
https://pubmed.ncbi.nlm.nih.gov/29577227
https://pubmed.ncbi.nlm.nih.gov/29577227
Autor:
Kumiko Ogawa, Kouhei Amakasu, Takuya Nishimura, Yukie Saegusa, Misaki Naota, Akiyoshi Nishikawa, Mizuho Nonaka
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 86
International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) has been conducting a prospective evaluation period to validate the criteria for waiving some carcinogenicity studies in rats.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cabb50dc843b93948478713a5266a61
https://pubmed.ncbi.nlm.nih.gov/28288808
https://pubmed.ncbi.nlm.nih.gov/28288808
Autor:
Akinori Shimada, Takehito Morita, Ken-ichiro Inoue, Hirohisa Takano, Misaki Naota, Yuko Yamamoto
Publikováno v:
Toxicologic Pathology. 41:487-496
Endocytosis is the primary mechanism by which nanoparticles are translocated over the alveolar epithelium. The purpose of this study was to elucidate the association between endocytosis and the translocation of nanoparticles at the air–blood barrie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2008560517b9709fb32e874903ea059a
https://doi.org/10.1177/0192623312457271
https://doi.org/10.1177/0192623312457271
Autor:
Misaki, Naota, Shizuka, Shiotsu, Akinori, Shimada, Yukari, Kohara, Takehito, Morita, Kenichiro, Inoue, Hirohisa, Takano
Publikováno v:
Toxicologic Pathology. 41:48-62
Asian sand dust (ASD) events are associated with an increase in pulmonary morbidity and mortality. The number of ASD events has increased rapidly in the east Asian region since 2000. To study the chronic lung toxicity of ASD, saline suspensions of lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b0f19082f2b2c10f697969816ca4a81
https://doi.org/10.1177/0192623312452490
https://doi.org/10.1177/0192623312452490
Publikováno v:
Journal of Veterinary Medical Science. 72:1359-1362
Pathological findings associated with scuticociliatosis in farmed Japanese flounder in Japan are described. Ten moribund fishes, farmed in Tottori Prefectural Fisheries Experimental Station, showed cutaneous ulcers, darkened skin, fin and tail rot, e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2a2365e36d11f966f541ac55d647c25
https://doi.org/10.1292/jvms.10-0026
https://doi.org/10.1292/jvms.10-0026
Publikováno v:
Toxicologic Pathology. 37:456-462
Ultrafine particles are ubiquitous in ambient urban and indoor air from multiple sources and may contribute to adverse respiratory and cardiovascular diseases. Recently, it has been demonstrated that ultrafine particles (UFPs) are translocated from t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94bcf07b26fcb0a3f8caf747edfdc3e3
https://doi.org/10.1177/0192623309335059
https://doi.org/10.1177/0192623309335059
Autor:
R. Aerni, Misaki Naota, Atsuhi Watanabe, Dai Nakae, Michael Wasko, Hirofumi Hatakeyama, Takayuki Anzai
Publikováno v:
Toxicology Letters. 280:S302
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17c0250defd41e577b477fda6fabc7f6
https://doi.org/10.1016/j.toxlet.2017.07.844
https://doi.org/10.1016/j.toxlet.2017.07.844