Výsledky vyhledávání - "Misa Matsubara"

Supplementary Figure S1 from Enhanced Antitumor Effects of Novel Intracellular Delivery of an Active Form of Menaquinone-4, Menahydroquinone-4, into Hepatocellular Carcinoma

Autor: Jiro Takata, Yoshiharu Karube, Morishige Takeshita, Manabu Nakashima, Munechika Enjoji, Nami Nagata-Akaho, Mariko Kusuda, Yohei Kubo, Misa Matsubara, Kazuhisa Matsunaga, Daisuke Watase, Shuichi Setoguchi

Supplementary Figure S1. Intracellular MKO and MK-4 levels after 24 h treatment with MKO in PLC/PRF/5 cells.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d42802ffb0b21c59851d08eec385e4ae
https://doi.org/10.1158/1940-6207.22527081.v1

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Supplementary Table S1 from Enhanced Antitumor Effects of Novel Intracellular Delivery of an Active Form of Menaquinone-4, Menahydroquinone-4, into Hepatocellular Carcinoma

Supplementary Table S1. Growth inhibition IC50 values of MK-4 and MKH-DMG against HCC cell lines after treatment with MK-4 or MKH-DMG.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4539b11e36b440b578348c8d1a2b0640
https://doi.org/10.1158/1940-6207.22527069

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Supplementary Table S3 from Enhanced Antitumor Effects of Novel Intracellular Delivery of an Active Form of Menaquinone-4, Menahydroquinone-4, into Hepatocellular Carcinoma

Supplementary Table S3. Effects of MKH-DMG on liver incidence and growth of DCP-positive HCC in a murine spleen-liver metastasis model.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::877ef930558d8dba6a8abac7e212fb73
https://doi.org/10.1158/1940-6207.22527063

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Supplementary Figure S2 from Enhanced Antitumor Effects of Novel Intracellular Delivery of an Active Form of Menaquinone-4, Menahydroquinone-4, into Hepatocellular Carcinoma

Supplementary Figure S2. Intracellular MKO and MK-4 levels after 24 h treatment with MKH-DMG or MK-4 in PLC/PRF/5 cells.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f38fa48cc8d20a81fbe736ce1b0dd87
https://doi.org/10.1158/1940-6207.22527078

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Data from Enhanced Antitumor Effects of Novel Intracellular Delivery of an Active Form of Menaquinone-4, Menahydroquinone-4, into Hepatocellular Carcinoma

Reduced cellular uptake of menaquinone-4 (MK-4), a vitamin K2 homolog, in human hepatocellular carcinoma (HCC) limits its usefulness as a safe long-term antitumor agent for recurrent HCC and produces des-γ-carboxy prothrombin (DCP). We hypothesized

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::09c3c4f1708f4f1ede7e3c4dc068c3c6
https://doi.org/10.1158/1940-6207.c.6545316.v1

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Supplementary Table S2 from Enhanced Antitumor Effects of Novel Intracellular Delivery of an Active Form of Menaquinone-4, Menahydroquinone-4, into Hepatocellular Carcinoma

Supplementary Table S2. Pharmacokinetic parameters of MKH-DMG and MK-4 in plasma and liver after p.o. administration of MKH-DMG in mice.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::168a6b7d265660b024029e9585881d89
https://doi.org/10.1158/1940-6207.22527066.v1

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Supplementary Figure S3 from Enhanced Antitumor Effects of Novel Intracellular Delivery of an Active Form of Menaquinone-4, Menahydroquinone-4, into Hepatocellular Carcinoma

Supplementary Figure S3. Plasma and liver concentration profiles of MK-4 and MKH-DMG after oral administration of MKH-DMG in mice.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1b20f13e11dba40c5fe0c598f627c37
https://doi.org/10.1158/1940-6207.22527075

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Supplementary Materials from Enhanced Antitumor Effects of Novel Intracellular Delivery of an Active Form of Menaquinone-4, Menahydroquinone-4, into Hepatocellular Carcinoma

Supplementary Materials. Supplementary Material and Methods, Results, References, and Figure legends.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5964bd87ca3729a732dd41715152b99
https://doi.org/10.1158/1940-6207.22527072

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Enhanced Antitumor Effects of Novel Intracellular Delivery of an Active Form of Menaquinone-4, Menahydroquinone-4, into Hepatocellular Carcinoma

Autor: Nami Nagata-Akaho, Kazuhisa Matsunaga, Manabu Nakashima, Yoshiharu Karube, Misa Matsubara, Daisuke Watase, Jiro Takata, Morishige Takeshita, Yohei Kubo, Munechika Enjoji, Shuichi Setoguchi, Mariko Kusuda

Publikováno v: Cancer Prevention Research. 8:129-138

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca33f77d8c74bb599368b21bb1ec4ad3
https://doi.org/10.1158/1940-6207.capr-14-0292

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