Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Misa Iwatani"'
Autor:
Kenichi Iwai, Masahiro Yaguchi, Kazuho Nishimura, Yukiko Yamamoto, Toshiya Tamura, Daisuke Nakata, Ryo Dairiki, Yoichi Kawakita, Ryo Mizojiri, Yoshiteru Ito, Moriteru Asano, Hironobu Maezaki, Yusuke Nakayama, Misato Kaishima, Kozo Hayashi, Mika Teratani, Shuichi Miyakawa, Misa Iwatani, Maki Miyamoto, Michael G Klein, Wes Lane, Gyorgy Snell, Richard Tjhen, Xingyue He, Sai Pulukuri, Toshiyuki Nomura
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 6, Pp 1-15 (2018)
Abstract The modulation of pre‐mRNA splicing is proposed as an attractive anti‐neoplastic strategy, especially for the cancers that exhibit aberrant pre‐mRNA splicing. Here, we discovered that T‐025 functions as an orally available and potent
Externí odkaz:
https://doaj.org/article/5f979a579b0246ad90c5cfcded6e406d
Autor:
Tyler Funnell, Shinya Tasaki, Arusha Oloumi, Shinsuke Araki, Esther Kong, Damian Yap, Yusuke Nakayama, Christopher S. Hughes, S.-W. Grace Cheng, Hirokazu Tozaki, Misa Iwatani, Satoshi Sasaki, Tomohiro Ohashi, Tohru Miyazaki, Nao Morishita, Daisuke Morishita, Mari Ogasawara-Shimizu, Momoko Ohori, Shoichi Nakao, Masatoshi Karashima, Masaya Sano, Aiko Murai, Toshiyuki Nomura, Noriko Uchiyama, Tomohiro Kawamoto, Ryujiro Hara, Osamu Nakanishi, Karey Shumansky, Jamie Rosner, Adrian Wan, Steven McKinney, Gregg B. Morin, Atsushi Nakanishi, Sohrab Shah, Hiroyoshi Toyoshiba, Samuel Aparicio
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
The phosphorylation of serine/arginine-rich proteins by CDC-like kinase is a central regulatory mechanism for RNA splicing reactions. Here, the authors synthesize a novel small molecule CLK inhibitor and map CLK-responsive alternative splicing events
Externí odkaz:
https://doaj.org/article/5aad2179e7e647afa20357dc81dea1bc
Autor:
Shinsuke Araki, Ryo Dairiki, Yusuke Nakayama, Aiko Murai, Risa Miyashita, Misa Iwatani, Toshiyuki Nomura, Osamu Nakanishi
Publikováno v:
PLoS ONE, Vol 10, Iss 1, p e0116929 (2015)
Accumulating evidence has demonstrated the importance of alternative splicing in various physiological processes, including the development of different diseases. CDC-like kinases (CLKs) and serine-arginine protein kinases (SRPKs) are components of t
Externí odkaz:
https://doaj.org/article/c03c65d55d8948bcbcc348848340aa05
Autor:
Yasushi Hattori, Shigemitsu Matsumoto, Shinji Morimoto, Masaki Daini, Masashi Toyofuku, Satoru Matsuda, Rina Baba, Koji Murakami, Misa Iwatani, Hideyuki Oki, Shinji Iwasaki, Kouta Matsumiya, Yusuke Tominari, Haruhide Kimura, Mitsuhiro Ito
Publikováno v:
European journal of medicinal chemistry. 239
Lysine-specific demethylase 1 (LSD1) is an enzyme that demethylates methylated histone H3 lysine 4 (H3K4). Inhibition of LSD1 enzyme activity could increase H3K4 methylation levels and treat diseases associated with epigenetic dysregulation. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1799e4688154809d1d4f50bf466e86b
https://pubmed.ncbi.nlm.nih.gov/35749987
https://pubmed.ncbi.nlm.nih.gov/35749987
Autor:
Toshio Tanaka, Tomohiro Kawamoto, Satoshi Endo, Samuel Aparicio, Michiko Tawada, Atsushi Nakanishi, Momoko Ohori, Douglas R. Cary, Masahiro Ito, Masahiro Nogami, Toshihiro Imaeda, Misa Iwatani, Shinsuke Araki, Shoichi Nakao, Yasuhiro Imaeda
Publikováno v:
Biochemical and Biophysical Research Communications. 523:795-801
The DEAD-box family of RNA helicases plays essential roles in both transcriptional and translational mRNA degradation; they unwind short double-stranded RNA by breaking the RNA-RNA interactions. Two DEAD-box RNA helicases, eukaryotic translation init
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f92b4a687affd66801c43aa881d530cd
https://doi.org/10.1016/j.bbrc.2019.12.094
https://doi.org/10.1016/j.bbrc.2019.12.094
Autor:
Shigeru Igaki, Ryosuke Hibino, Ken Tsuchida, Shinji Iwasaki, Satoru Matsuda, Ryujiro Hara, Hiroko Kamada, Masashi Toyofuku, Haruhide Kimura, Misa Iwatani, Rina Baba, Mitsuhiro Ito, Kota Matsumiya, Hideyuki Oki, Yusuke Kamada, Takeshi Hirakawa, Shinji Morimoto
Publikováno v:
Neuropsychopharmacology
Dysregulation of histone H3 lysine 4 (H3K4) methylation has been implicated in the pathogenesis of several neurodevelopmental disorders. Targeting lysine-specific demethylase 1 (LSD1), an H3K4 demethylase, is therefore a promising approach to treat t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6a412d79e9c823a65878035790b06f0
https://doi.org/10.1038/s41386-018-0300-9
https://doi.org/10.1038/s41386-018-0300-9
Autor:
Takahito Hara, Satoshi Kitazawa, Misa Iwatani, Hitoshi Miyashita, Ryutaro Adachi, Yukiko Yamamoto, Megumi Morimoto, Takeo Arita, Sou Sakamoto, Takaharu Hirayama, Kazumasa Miyamoto
Publikováno v:
Biochemical and Biophysical Research Communications. 488:648-654
Protein translation is highly activated in cancer tissues through oncogenic mutations and amplifications, and this can support survival and aberrant proliferation. Therefore, blocking translation could be a promising way to block cancer progression.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fda348abfaf1262d6c6f1c6c91988b09
https://doi.org/10.1016/j.bbrc.2017.01.045
https://doi.org/10.1016/j.bbrc.2017.01.045
Autor:
Samuel Aparicio, Tomohiro Kawamoto, Yoshihiro Ishibashi, Atsushi Nakanishi, Hiromichi Kimura, Daisuke Morishita, Misa Iwatani-Yoshihara, Takashi Ito, Hideyuki Oki, Yasuhiro Imaeda, Toshio Tanaka, Masahiro Ito
Publikováno v:
ACS Chemical Biology. 12:1760-1768
Eukaryotic initiation factor 4A-3 (eIF4A3) is an Asp-Glu-Ala-Asp (DEAD) box-family adenosine triphosphate (ATP)-dependent RNA helicase. Subtypes eIF4A1 and eIF4A2 are required for translation initiation, but eIF4A3 participates in the exon junction c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed64391b881c548a1b4fda32aaa18a7d
https://doi.org/10.1021/acschembio.7b00041
https://doi.org/10.1021/acschembio.7b00041
Autor:
Masahiro Ito, Misa Iwatani-Yoshihara, Yusuke Kamada, Samuel Aparicio, Toshio Tanaka, Douglas R. Cary, Yasuhiro Imaeda, Atsushi Nakanishi, Tomohiro Kawamoto
Publikováno v:
Journal of Medicinal Chemistry. 60:3335-3351
Eukaryotic initiation factor 4A3 (eIF4A3), a member of the DEAD-box RNA helicase family, is one of the core components of the exon junction complex (EJC). The EJC is known to be involved in a variety of RNA metabolic processes typified by nonsense-me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11ae55102dd517a13f30761ae1b802cf
https://doi.org/10.1021/acs.jmedchem.6b01904
https://doi.org/10.1021/acs.jmedchem.6b01904
Autor:
Satoshi Sogabe, Shoichi Nakao, Tomohiro Kawamoto, Misa Iwatani, Samuel Aparicio, Yasuhiro Imaeda, Toshio Tanaka, Masahiro Ito, Atsushi Nakanishi, Yusuke Kamada
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:2200-2209
Eukaryotic initiation factor 4A3 (eIF4A3), an ATP-dependent RNA helicase, is a core component of exon junction complex (EJC). EJC has a variety of roles in RNA metabolism such as translation, surveillance, and localization of spliced RNA. It is worth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51f3dbea65dffc37af9d2c56295f85a2
https://doi.org/10.1016/j.bmc.2017.02.035
https://doi.org/10.1016/j.bmc.2017.02.035