Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Mirvat El‑Sibai"'
Publikováno v:
Journal of Ovarian Research, Vol 14, Iss 1, Pp 1-13 (2021)
Abstract Ovarian carcinoma is the second most common malignancy of the female reproductive system and the leading cause of death from female reproductive system malignancies. Cancer cells have increased proliferation rate and thus require high amount
Externí odkaz:
https://doaj.org/article/042919373684419daae46922977d6156
Autor:
Maria Al Haddad, Rayane El-Rif, Samer Hanna, Leila Jaafar, Rayanne Dennaoui, Sandra Abdellatef, Veronika Miskolci, Dianne Cox, Louis Hodgson, Mirvat El-Sibai
Publikováno v:
Cell Communication and Signaling, Vol 18, Iss 1, Pp 1-20 (2020)
Abstract Background Lung cancer is the second most commonly occurring cancer. The ability to metastasize and spread to distant locations renders the tumor more aggressive. Members of the Rho subfamily of small GTP-binding proteins (GTPases) play a ce
Externí odkaz:
https://doaj.org/article/0b319368d53a441ea31896eff857c9af
Publikováno v:
Cancer Cell International, Vol 20, Iss 1, Pp 1-7 (2020)
Abstract Arginine is a semi essential amino acid that is used in protein biosynthesis. It can be obtained from daily food intake or synthesized in the body through the urea cycle using l-citrulline as a substrate. Arginine has a versatile role in the
Externí odkaz:
https://doaj.org/article/1c43eebceeb64183be3b932b53565fa9
Autor:
Sandra Abdellatef, Isabelle Fakhoury, Maria Al Haddad, Leila Jaafar, Hiba Maalouf, Samer Hanna, Bassem Khalil, Zeinab El Masri, Louis Hodgson, Mirvat El-Sibai
Publikováno v:
European Journal of Cell Biology, Vol 101, Iss 1, Pp 151197- (2022)
Metastasis remains the main challenge to overcome for treating ovarian cancers. In this study, we investigate the potential role of the Cdc42 GAP StarD13 in the modulation of cell motility, invasion in ovarian cancer cells. StarD13 depletion does not
Externí odkaz:
https://doaj.org/article/c030646bb245450f846b4f07b00e9590
Autor:
Nada El Baba, Mohammad Farran, Elie Abi Khalil, Leila Jaafar, Isabelle Fakhoury, Mirvat El-Sibai
Publikováno v:
Analytical Cellular Pathology, Vol 2020 (2020)
Vascular endothelial growth factors (VEGFs) consist of five molecules (VEGFA through D as well as placental growth factor) which are crucial for regulating key cellular and tissue functions. The role of VEGF and its intracellular signaling and downst
Externí odkaz:
https://doaj.org/article/a2457c03d5f94bfba1e2e88b9cfd517e
Publikováno v:
Analytical Cellular Pathology, Vol 2020 (2020)
Astrocytomas are primary malignant brain tumors that originate from astrocytes. Grade IV astrocytoma or glioblastoma is a highly invasive tumor that occur within the brain parenchyma. The Rho family of small GTPases, which includes Rac1, Cdc42, and R
Externí odkaz:
https://doaj.org/article/dbde02174595449f80f3bbaabfe3529b
Autor:
Marwa Al Hassan, Isabelle Fakhoury, Zeinab El Masri, Noura Ghazale, Rayane Dennaoui, Oula El Atat, Amjad Kanaan, Mirvat El-Sibai
Publikováno v:
Analytical Cellular Pathology, Vol 2018 (2018)
Glioblastoma multiforme (GBM) is one of the most common and deadliest cancers of the central nervous system (CNS). GBMs high ability to infiltrate healthy brain tissues makes it difficult to remove surgically and account for its fatal outcomes. To im
Externí odkaz:
https://doaj.org/article/9dd354fd96cd40369f082d41a38cc0a5
Publikováno v:
Cells, Vol 8, Iss 11, p 1397 (2019)
Glioblastoma multiforme (GBM) is one of the most common and deadly cancers of the central nervous system (CNS). It is characterized by the presence of hypoxic regions, especially in the core, leading to an increase in vascularity. This increased vasc
Externí odkaz:
https://doaj.org/article/223eddaf003f4210b940fc378f6ef8a8
Publikováno v:
Cells, Vol 8, Iss 2, p 171 (2019)
Angiogenesis is a hallmark of cancer cell malignancy. The role of the RHO family GTPase RHOG in angiogenesis in vascular endothelial cells has recently been elucidated. However, the regulation of RHOG during this process, as well as its cross-talk wi
Externí odkaz:
https://doaj.org/article/8fc85de4d8d0450795c3926fb1a2b660
Publikováno v:
Mediators of Inflammation, Vol 11, Iss 1, Pp 39-45 (2002)
Background: In inflammatory bowel disease (IBD), cytokine levels (such as interleukin-1 (IL-1)) are elevated. We have shown previously that IL-1 activates phospholipid signaling pathways in intestinal epithelial cells (IEC), leading to increased cera
Externí odkaz:
https://doaj.org/article/c07ad54111f9496b99be7e7848d63229