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Autor:
Kenneth Alan Simmen, Tatiana Agback, Michael Pelcman, Herman de Kock, Horst Wähling, Christina Rydegård, Joseph A. Martin, Magnus Nilsson, Pierre Raboisson, Pedro Pinho, Xiao Xiong Zhou, Anna Winqvist, Kurt Benckestock, David Bernard Smith, Mirva Boothee, Christian Sund, Bertil Samuelsson, Lotta Vrang, Åsa Rosenquist, Nils Gunnar Johansson, Anna Karin Gertrud Linnea Belfrage, Sophie Lachau-Durand, Klaus Klumpp, Koen Vandyck, Kristina Wikström, Ylva Terelius, Tim H. M. Jonckers, Tse-I Lin, Genadiy Kalayanov, Anneli Lindqvist
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(9)
4′-Azido-2′-deoxy-2′-methylcytidine ( 14 ) is a potent nucleoside inhibitor of the HCV NS5B RNA-dependent RNA polymerase, displaying an EC 50 value of 1.2 μM and showing moderate in vivo bioavailability in rat ( F = 14%). Here we describe the