Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Miruna C Barbu"'
Autor:
Danni A. Gadd, Robert F. Hillary, Daniel L. McCartney, Liu Shi, Aleks Stolicyn, Neil A. Robertson, Rosie M. Walker, Robert I. McGeachan, Archie Campbell, Shen Xueyi, Miruna C. Barbu, Claire Green, Stewart W. Morris, Mathew A. Harris, Ellen V. Backhouse, Joanna M. Wardlaw, J. Douglas Steele, Diego A. Oyarzún, Graciela Muniz-Terrera, Craig Ritchie, Alejo Nevado-Holgado, Tamir Chandra, Caroline Hayward, Kathryn L. Evans, David J. Porteous, Simon R. Cox, Heather C. Whalley, Andrew M. McIntosh, Riccardo E. Marioni
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Characterising associations between the methylome, proteome and phenome may provide insight into biological pathways governing brain health. Here, blood protein markers of brain health are integrated with omics data to reveal DNA methylation differen
Externí odkaz:
https://doaj.org/article/1eaa7fc6efbf4260a056871f0b0cae03
Autor:
Mathew A. Harris, Simon R. Cox, Laura de Nooij, Miruna C. Barbu, Mark J. Adams, Xueyi Shen, Ian J. Deary, Stephen M. Lawrie, Andrew M. McIntosh, Heather C. Whalley
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Depression is assessed in various ways in research, with large population studies often relying on minimal phenotyping. Genetic results suggest clinical diagnoses and self-report measures of depression show some core similarities, but also i
Externí odkaz:
https://doaj.org/article/aab0a5a9ff184c02856fc613af0c3079
Autor:
Xueyi Shen, Doretta Caramaschi, Mark J. Adams, Rosie M. Walker, Josine L. Min, Alex Kwong, Gibran Hemani, Genetics of DNA Methylation Consortium, Miruna C. Barbu, Heather C. Whalley, Sarah E. Harris, Ian J. Deary, Stewart W. Morris, Simon R. Cox, Caroline L. Relton, Riccardo E. Marioni, Kathryn L. Evans, Andrew M. McIntosh
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-16 (2022)
Abstract Background Depression is a disabling and highly prevalent condition where genetic and epigenetic, such as DNA methylation (DNAm), differences contribute to disease risk. DNA methylation is influenced by genetic variation but the association
Externí odkaz:
https://doaj.org/article/d2acf3cdcee6403f88223fb30ff43ea6
Autor:
Amelia J. Edmondson-Stait, Xueyi Shen, Mark J. Adams, Miruna C. Barbu, Hannah J. Jones, Veronique E. Miron, Judith Allardyce, James P. Boardman, Stephen M. Lawrie, Andrew M. McIntosh, Golam M. Khandaker, Alex S.F. Kwong, Heather C. Whalley
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 26, Iss , Pp 100528- (2022)
Inflammation is implicated in depression and psychosis, including association of childhood inflammatory markers on the subsequent risk of developing symptoms. However, it is unknown whether early-life inflammatory markers are associated with the numb
Externí odkaz:
https://doaj.org/article/f88a130972c04c3db498c86226a54915
Autor:
Claire Green, Aleks Stolicyn, Mathew A. Harris, Xueyi Shen, Liana Romaniuk, Miruna C. Barbu, Emma L. Hawkins, Joanna M. Wardlaw, J. Douglas Steele, Gordon D. Waiter, Anca-Larisa Sandu, Archie Campbell, David J. Porteous, Jonathan R. Seckl, Stephen M. Lawrie, Rebecca M. Reynolds, Jonathan Cavanagh, Andrew M. McIntosh, Heather C. Whalley
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Hypothalamic–pituitary–adrenal (HPA) axis dysregulation has been commonly reported in major depressive disorder (MDD), but with considerable heterogeneity of results; potentially due to the predominant use of acute measures of an inheren
Externí odkaz:
https://doaj.org/article/89b054256ca14047ae3a738743e18a0d
Autor:
Julie Schoorl, Miruna C. Barbu, Xueyi Shen, Mat R. Harris, Mark J. Adams, Heather C. Whalley, Stephen M. Lawrie
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract There has been a substantial amount of research reporting the neuroanatomical associations of psychotic symptoms in people with schizophrenia. Comparatively little attention has been paid to the neuroimaging correlates of subclinical psychot
Externí odkaz:
https://doaj.org/article/0663714d8b4c4b72aeca01b89a52e1e2
Autor:
Miruna C. Barbu, Carmen Amador, Alex S.F. Kwong, Xueyi Shen, Mark J. Adams, David M. Howard, Rosie M. Walker, Stewart W. Morris, Josine L. Min, Chunyu Liu, Jenny van Dongen, Mohsen Ghanbari, Caroline Relton, David J. Porteous, Archie Campbell, Kathryn L. Evans, Heather C. Whalley, Andrew M. McIntosh
Publikováno v:
EBioMedicine, Vol 79, Iss , Pp 104000- (2022)
Summary: Background: DNA methylation (DNAm) is associated with time-varying environmental factors that contribute to major depressive disorder (MDD) risk. We sought to test whether DNAm signatures of lifestyle and biochemical factors were associated
Externí odkaz:
https://doaj.org/article/f2438b9b8f5a489eb3648ba1916d4d96
Autor:
Gladi Thng, Xueyi Shen, Aleks Stolicyn, Mathew A. Harris, Mark J. Adams, Miruna C. Barbu, Alex S. F. Kwong, Sophia Frangou, Stephen M. Lawrie, Andrew M. McIntosh, Liana Romaniuk, Heather C. Whalley
Publikováno v:
European Psychiatry, Vol 65 (2022)
Abstract Background Major depressive disorder (MDD) is a polygenic disorder associated with brain alterations but until recently, there have been no brain-based metrics to quantify individual-level variation in brain morphology. Here, we evaluated a
Externí odkaz:
https://doaj.org/article/50eb08abd1764d5fadc0c0b451a255a7
Autor:
Xueyi Shen, Niamh MacSweeney, Stella W.Y. Chan, Miruna C. Barbu, Mark J. Adams, Stephen M. Lawrie, Liana Romaniuk, Andrew M. McIntosh, Heather C. Whalley
Publikováno v:
EClinicalMedicine, Vol 42, Iss , Pp 101204- (2021)
Background: Depression is the leading cause of disability worldwide with > 50% of cases emerging before the age of 25 years. Large-scale neuroimaging studies in depression implicate robust structural brain differences in the disorder. However, most s
Externí odkaz:
https://doaj.org/article/4a66f628d303496fb92046dc6b56d62d
Autor:
Mathew A. Harris, Simon R. Cox, Laura de Nooij, Miruna C. Barbu, Mark J. Adams, Xueyi Shen, Ian J. Deary, Stephen M. Lawrie, Andrew M. McIntosh, Heather C. Whalley
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/3ec263912b06456d9bb62bb050a38bb0