Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Mirtha Elisa Aguado"'
Autor:
Maikel Izquierdo, De Lin, Sandra O'Neill, Lauren A Webster, Christy Paterson, John Thomas, Mirtha Elisa Aguado, Enrique Colina Araújo, Daniel Alpízar-Pedraza, Halimatu Joji, Lorna MacLean, Anthony Hope, David W Gray, Martin Zoltner, Mark C Field, Jorge González-Bacerio, Manu De Rycker
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 18, Iss 2, p e0011956 (2024)
BackgroundChagas disease is caused by the protozoan parasite Trypanosoma cruzi and leads to ~10,000 deaths each year. Nifurtimox and benznidazole are the only two drugs available but have significant adverse effects and limited efficacy. New chemothe
Externí odkaz:
https://doaj.org/article/eda16b548238447697b8e6f336b5e1ca
Autor:
Jorge González-Bacerio, Maikel Izquierdo, Mirtha Elisa Aguado, Ana C. Varela, Maikel González-Matos, Maday Alonso del Rivero
Publikováno v:
Microbial Cell, Vol 8, Iss 10, Pp 239-246 (2021)
Several microbial metalo-aminopeptidases are emerging as novel targets for the treatment of human infectious diseases. Some of them are well validated as targets and some are not; some are essential enzymes and others are important for virulence and
Externí odkaz:
https://doaj.org/article/6d46b80827814f7c83550a392acbfd4b
Autor:
Jorge González-Bacerio, Irina Arocha, Mirtha Elisa Aguado, Yanira Méndez, Sabrina Marsiccobetre, Maikel Izquierdo, Daniel G. Rivera, Katherine Figarella, Néstor L. Uzcátegui
Publikováno v:
Life, Vol 11, Iss 10, p 1037 (2021)
Chagas disease, caused by the kinetoplastid parasite Trypanosoma cruzi, is a human tropical illness mainly present in Latin America. The therapies available against this disease are far from ideal. Proteases from pathogenic protozoan have been consid
Externí odkaz:
https://doaj.org/article/76ac9f2e5b3e4002a1b154edd177f810
Autor:
Jorge González-Bacerio, Mirtha Elisa Aguado, Maikel Izquierdo, Maikel González-Matos, Ana C. Varela, Yanira Méndez, Maday Alonso del Rivero, Daniel G. Rivera
Publikováno v:
Current Drug Targets. 24:416-461
Background: Parasitic human infectious diseases are a worldwide health problem due to the increased resistance to conventional drugs. For this reason, the identification of novel molecular targets and the discovery of new chemotherapeutic agents are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7296af1e4ae96615c996e297b4b30a0a
https://doi.org/10.2174/1389450124666230224140724
https://doi.org/10.2174/1389450124666230224140724
Autor:
Maikel González-Matos, Ana C. Varela, Maday Alonso del Rivero, Mirtha Elisa Aguado, Jorge González-Bacerio, Maikel Izquierdo
Publikováno v:
Microbial Cell
Microbial Cell, Vol 8, Iss 10, Pp 239-246 (2021)
Microbial Cell, Vol 8, Iss 10, Pp 239-246 (2021)
Several microbial metalo-aminopeptidases are emerging as novel targets for the treatment of human infectious diseases. Some of them are well validated as targets and some are not; some are essential enzymes and others are important for virulence and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15bc7ecae936c3447d081353e04c83bb
https://doi.org/10.15698/mic2021.10.761
https://doi.org/10.15698/mic2021.10.761
Autor:
Sabrina Marsiccobetre, Mirtha Elisa Aguado, Katherine Figarella, Yanira Méndez, Irina Arocha, Daniel G. Rivera, Néstor L. Uzcátegui, Jorge González-Bacerio, Maikel Izquierdo
Publikováno v:
Life, Vol 11, Iss 1037, p 1037 (2021)
Life
Volume 11
Issue 10
Life
Volume 11
Issue 10
Chagas disease, caused by the kinetoplastid parasite Trypanosoma cruzi, is a human tropical illness mainly present in Latin America. The therapies available against this disease are far from ideal. Proteases from pathogenic protozoan have been consid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cca5670adfef34ce6d095dc87d09cbd7
https://www.mdpi.com/2075-1729/11/10/1037
https://www.mdpi.com/2075-1729/11/10/1037
Autor:
Maikel González-Matos, Juan F. Quintana, Jorge González-Bacerio, Maikel Izquierdo, Mirtha Elisa Aguado, Mark C. Field
Publikováno v:
Protein expression and purification. 183
The Leishmania major leucyl-aminopeptidase (LAPLm), a member of the M17 family of proteases, is a potential drug target for treatment of leishmaniasis. To better characterize enzyme properties, recombinant LAPLm (rLAPLm) was expressed in Escherichia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11d6f113cc8f5ff3c7ee50da3f665c33
https://pubmed.ncbi.nlm.nih.gov/33775769
https://pubmed.ncbi.nlm.nih.gov/33775769
Publikováno v:
The protein journal. 38(2)
The M17 leucyl-aminopeptidase of Trypanosoma cruzi (LAPTc) is a novel drug target for Chagas disease. The objective of this work was to obtain recombinant LAPTc (rLAPTc) in Escherichia coli. A LAPTc gene was designed, optimized for its expression in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b27fe4338e303b4c00941087bf2299cd
https://pubmed.ncbi.nlm.nih.gov/30905022
https://pubmed.ncbi.nlm.nih.gov/30905022