Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Mirra Chung"'
Autor:
Marian Kalocsay, Matthew J. Berberich, Robert A. Everley, Maulik K. Nariya, Mirra Chung, Benjamin Gaudio, Chiara Victor, Gary A. Bradshaw, Robyn J. Eisert, Marc Hafner, Peter K. Sorger, Caitlin E. Mills, Kartik Subramanian
Publikováno v:
Scientific Data, Vol 10, Iss 1, Pp 1-9 (2023)
Abstract We performed quantitative proteomics on 60 human-derived breast cancer cell line models to a depth of ~13,000 proteins. The resulting high-throughput datasets were assessed for quality and reproducibility. We used the datasets to identify an
Externí odkaz:
https://doaj.org/article/d36f69bd2a254d5687bc8e7f98e95fc1
Autor:
Huan Wang, Yiming Wang, Jiongyuan Li, Ziyi He, Sarah A. Boswell, Mirra Chung, Fuping You, Sen Han
Publikováno v:
BMC Medicine, Vol 21, Iss 1, Pp 1-21 (2023)
Abstract Background Tyrosine kinase inhibitors (TKIs) are anti-cancer therapeutics often prescribed for long-term treatment. Many of these treatments cause cardiotoxicity with limited cure. We aim to clarify molecular mechanisms of TKI-induced cardio
Externí odkaz:
https://doaj.org/article/96fac43db70b418382c36d847c4bcc4f
Autor:
Caitlin E. Mills, Kartik Subramanian, Marc Hafner, Mario Niepel, Luca Gerosa, Mirra Chung, Chiara Victor, Benjamin Gaudio, Clarence Yapp, Ajit J. Nirmal, Nicholas Clark, Peter K. Sorger
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
It is currently difficult to perform accurate single-cell assays in 384-well plates. Here the authors report Dye Drop which uses sequential density displacement and microscopy for multi-step assays on cells, and use this to collect single-cell dose-r
Externí odkaz:
https://doaj.org/article/fd5702d7273c4618abdb7be6d446e8fd
Autor:
Sean M. Gross, Mark A. Dane, Rebecca L. Smith, Kaylyn L. Devlin, Ian C. McLean, Daniel S. Derrick, Caitlin E. Mills, Kartik Subramanian, Alexandra B. London, Denis Torre, John Erol Evangelista, Daniel J. B. Clarke, Zhuorui Xie, Cemal Erdem, Nicholas Lyons, Ted Natoli, Sarah Pessa, Xiaodong Lu, James Mullahoo, Jonathan Li, Miriam Adam, Brook Wassie, Moqing Liu, David F. Kilburn, Tiera A. Liby, Elmar Bucher, Crystal Sanchez-Aguila, Kenneth Daily, Larsson Omberg, Yunguan Wang, Connor Jacobson, Clarence Yapp, Mirra Chung, Dusica Vidovic, Yiling Lu, Stephan Schurer, Albert Lee, Ajay Pillai, Aravind Subramanian, Malvina Papanastasiou, Ernest Fraenkel, Heidi S. Feiler, Gordon B. Mills, Jake D. Jaffe, Avi Ma’ayan, Marc R. Birtwistle, Peter K. Sorger, James E. Korkola, Joe W. Gray, Laura M. Heiser
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-20 (2022)
Comprehensive profiling of ligand-induced perturbation responses of the MCF10A mammary epithelial cell line provides an exhaustive resource for identification of the molecular basis of cellular phenotypes.
Externí odkaz:
https://doaj.org/article/50400b000ed946209179e826cd85298c
Autor:
Mario Niepel, Marc Hafner, Qiaonan Duan, Zichen Wang, Evan O. Paull, Mirra Chung, Xiaodong Lu, Joshua M. Stuart, Todd R. Golub, Aravind Subramanian, Avi Ma’ayan, Peter K. Sorger
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Understanding why some tumor cells respond to therapy and others do not is essential for advancing precision cancer care. Here, the authors perform large-scale transcriptomic profiling of breast cancer cell lines treated with anti-cancer drugs and fi
Externí odkaz:
https://doaj.org/article/57f6fd3a402544048badc526067a421b
Autor:
Alessandro Marsili, Cristina Aguayo-Mazzucato, Ting Chen, Aditi Kumar, Mirra Chung, Elaine P Lunsford, John W Harney, Thuy Van-Tran, Elena Gianetti, Waile Ramadan, Cyril Chou, Susan Bonner-Weir, Philip Reed Larsen, Jorge Enrique Silva, Ann Marie Zavacki
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20832 (2011)
The type 2 iodothyronine deiodinase (D2) converts the pro-hormone thyroxine into T3 within target tissues. D2 is essential for a full thermogenic response of brown adipose tissue (BAT), and mice with a disrupted Dio2 gene (D2KO) have an impaired resp
Externí odkaz:
https://doaj.org/article/1dcafe8836a342b4998ec3bb4a900dd3
Autor:
Caitlin Mills, Kartik Subramanian, Marc Hafner, Mario Niepel, Luca Gerosa, Mirra Chung, Chiara Victor, Benjamin Gaudio, Clarence Yapp, Ajit Johnson Nirmal, Nicholas Clark, Peter Sorger
High-throughput measurement of cells perturbed using libraries of small molecules, gene knockouts, or different microenvironmental factors is a key step in functional genomics and pre-clinical drug discovery. However, it remains difficult to perform
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca4c87a1f1309ca57bb83ba37f2ab55c
https://doi.org/10.21203/rs.3.rs-1813095/v1
https://doi.org/10.21203/rs.3.rs-1813095/v1
Autor:
Derek H. Oakley, Caitlin Commins, Matthew P. Frosch, Simon Dujardin, Mirra Chung, Bradley T. Hyman, Rachel E. Bennett, Naomi Klickstein
Publikováno v:
The Journal of Neuroscience
Tau aggregation within neurons is a critical feature of Alzheimer's disease (AD) and related tauopathies. It is believed that soluble pathologic tau species seed the formation of tau aggregates in a prion-like manner and propagate through connected n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb21addd0ffb109091b3e2bb911d6459
https://doi.org/10.1523/jneurosci.2590-20.2021
https://doi.org/10.1523/jneurosci.2590-20.2021
Autor:
Chiara Victor, Luca Gerosa, Ben Gaudio, Mario Niepel, Kartik Subramanian, Marc Hafner, Peter K. Sorger, Mirra Chung, Clarence Yapp, Caitlin E. Mills
High-throughput measurement of cells perturbed using libraries of small molecules, gene knockouts, or different microenvironmental factors is a key step in functional genomics and pre-clinical drug discovery. However, it remains difficult to perform
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5c359da92cf23f9d735736ac8beec71
https://doi.org/10.1101/2021.08.27.457854
https://doi.org/10.1101/2021.08.27.457854
Autor:
Caitlin E. Mills, Kartik Subramanian, Marc Hafner, Mario Niepel, Luca Gerosa, Mirra Chung, Chiara Victor, Benjamin Gaudio, Clarence Yapp, Ajit J. Nirmal, Nicholas Clark, Peter K. Sorger
Publikováno v:
Nature communications. 13(1)
High-throughput measurement of cells perturbed using libraries of small molecules, gene knockouts, or different microenvironmental factors is a key step in functional genomics and pre-clinical drug discovery. However, it remains difficult to perform
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::365462974961e3419be2e33b999f3b43
https://pubmed.ncbi.nlm.nih.gov/36376301
https://pubmed.ncbi.nlm.nih.gov/36376301