Zobrazeno 1 - 10
of 277
pro vyhledávání: '"Miroslaw, Cygler"'
Autor:
Monica Rolando, Ivy Yeuk Wah Chung, Caishuang Xu, Laura Gomez-Valero, Patrick England, Miroslaw Cygler, Carmen Buchrieser
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT Legionella pneumophila is a bacterial pathogen ubiquitous in natural and man-made aquatic environments, where it replicates in protozoa. Its intracellular life cycle depends on the establishment of a Legionella-containing vacuole (LCV) where
Externí odkaz:
https://doaj.org/article/26ec4e0656494b79ac181002d73bfbb5
Autor:
Sven-A. Freibert, Michal T. Boniecki, Claudia Stümpfig, Vinzent Schulz, Nils Krapoth, Dennis R. Winge, Ulrich Mühlenhoff, Oliver Stehling, Miroslaw Cygler, Roland Lill
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
[2Fe-2S] protein cofactors are essential for life and are synthesized on ISCU2 scaffolds. Here, the authors show that hydrophobic interaction of two conserved N-terminal tyrosines induces ISCU2 dimerization and concomitant [2Fe-2S] cluster synthesis.
Externí odkaz:
https://doaj.org/article/c031fda3199f4ae4ade00e57b4490d02
Autor:
Kirsten C. Boddy, Hongxian Zhu, Vanessa M. D’Costa, Caishuang Xu, Ksenia Beyrakhova, Miroslaw Cygler, Sergio Grinstein, Etienne Coyaud, Estelle M. N. Laurent, Jonathan St-Germain, Brian Raught, John H. Brumell
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Salmonella secretes the effector protein SopD into the host cell cytoplasm, leading to scission of the plasma membrane through unclear mechanisms. Here, Boddy et al. show that SopD binds to and inhibits the small GTPase Rab10, thus promoting removal
Externí odkaz:
https://doaj.org/article/c637d11be435406898ecf3fc34ead099
Autor:
Bethany Vaughn, Kevin Voth, Christopher T. Price, Snake Jones, Mateja Ozanic, Marina Santic, Miroslaw Cygler, Yousef Abu Kwaik
Publikováno v:
mBio, Vol 12, Iss 1 (2021)
Intracellular proliferation of Legionella pneumophilaL. pneumophila
Externí odkaz:
https://doaj.org/article/d790a4326841498a97f11d2cb26d4152
Autor:
Kevin Voth, Shivani Pasricha, Ivy Yeuk Wah Chung, Rachelia R. Wibawa, Engku Nuraishah Huda E. Zainudin, Elizabeth L. Hartland, Miroslaw Cygler
Publikováno v:
Biomolecules, Vol 11, Iss 12, p 1802 (2021)
Legionella pneumophila is a Gram-negative intracellular pathogen that causes Legionnaires’ disease in elderly or immunocompromised individuals. This bacterium relies on the Dot/Icm (Defective in organelle trafficking/Intracellular multiplication) T
Externí odkaz:
https://doaj.org/article/eac745ce214746fbb4b20196721fa575
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Fe/S clusters are synthesized by the mitochondrial iron-sulfur cluster assembly (ISC) machinery. Here the authors combine crystallography and small angle X-ray scattering measurements to structurally characterize the core ISC complex and give functio
Externí odkaz:
https://doaj.org/article/380f33a1b9c943c18f6f4d959f2218f2
Autor:
Ivy Yeuk Wah Chung, Miroslaw Cygler
Publikováno v:
Acta Crystallogr F Struct Biol Commun
The bacterium Legionella pneumophila is a causative agent of Legionnaires' disease. It utilizes the Dot/Icm type IV secretion system (T4SS) to deliver over 300 effector proteins into the host cell, leading to modification of cellular processes and cr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4034e2048e1c66d3737470df12adb95
https://doi.org/10.1107/s2053230x22006604
https://doi.org/10.1107/s2053230x22006604
Autor:
Juanita Von Dwingelo, Ivy Yeuk Wah Chung, Christopher T. Price, Lei Li, Snake Jones, Miroslaw Cygler, Yousef Abu Kwaik
Publikováno v:
mBio, Vol 10, Iss 4 (2019)
ABSTRACT Species of the Legionella genus encode at least 18,000 effector proteins that are translocated through the Dot/Icm type IVB translocation system into macrophages and protist hosts to enable intracellular growth. Eight effectors, including an
Externí odkaz:
https://doaj.org/article/7bfe82e9c20c4ed9a96d335fee24c1d8
Autor:
Vanessa M. D’Costa, Virginie Braun, Marija Landekic, Rong Shi, Ariane Proteau, Laura McDonald, Miroslaw Cygler, Sergio Grinstein, John H. Brumell
Publikováno v:
Cell Reports, Vol 12, Iss 9, Pp 1508-1518 (2015)
Intracellular bacterial pathogens of a diverse nature share the ability to evade host immunity by impairing trafficking of endocytic cargo to lysosomes for degradation, a process that is poorly understood. Here, we show that the Salmonella enterica t
Externí odkaz:
https://doaj.org/article/17bde13531c845b49f53f66a85fa1101
Autor:
Andrey M. Grishin, Miroslaw Cygler
Publikováno v:
Biology, Vol 4, Iss 2, Pp 424-442 (2015)
Aromatic compounds are the second most abundant class of molecules on the earth and frequent environmental pollutants. They are difficult to metabolize due to an inert chemical structure, and of all living organisms, only microbes have evolved bioche
Externí odkaz:
https://doaj.org/article/7dca2589a45a43c481e352fe05119fb2