Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Miroslava Zoldakova"'
Autor:
Benedikt Linder, Miroslava Zoldakova, Zsuzsanna Kornyei, Leonhard H. F. Köhler, Sebastian Seibt, Dominic Menger, André Wetzel, Emília Madarász, Rainer Schobert, Donat Kögel, Bernhard Biersack
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 16; Pages: 9056
While the fungal metabolite illudin M (1) is indiscriminately cytotoxic in cancer and non-malignant cells, its retinoate 2 showed a greater selectivity for the former, especially in a cerebral context. Illudin M killed malignant glioma cells as well
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b091f482228a520da3ed21db9cc12c59
https://pubmed.ncbi.nlm.nih.gov/36012321
https://pubmed.ncbi.nlm.nih.gov/36012321
Publikováno v:
Applied Organometallic Chemistry. 25:117-120
The objective of this work was to combine the ABC-transporter inhibition characteristic of esters of the Schisandra sphenantera metabolite schisandrol A with the growth inhibitory and anti-migratory effects typical of titanium complexes. To this end
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4733771248e0766a9d7253047676283e
https://doi.org/10.1002/aoc.1725
https://doi.org/10.1002/aoc.1725
Publikováno v:
European Journal of Medicinal Chemistry. 45:1972-1975
Ru(eta6-arene) complexes of epidermal growth factor receptor (EGFR) inhibiting tyrphostins 1a and 1b were prepared, characterized and tested for DNA interaction and bioactivity in four human tumor cell lines. The intrinsic cytotoxicity and cell line
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11c47f82a2e029e99bc64666d1f76e20
https://doi.org/10.1016/j.ejmech.2010.01.040
https://doi.org/10.1016/j.ejmech.2010.01.040
Publikováno v:
Tetrahedron Letters. 49:3359-3362
Schisandrol A, a dibenzocyclooctadiene lignan, was obtained by a simplified procedure from Schisandra chinensis fruits. Its reaction with carboxylic acids to give new esters (schisantherins) required special conditions such as microwave irradiation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1967f57155e7d680bf4b62e7dac42f76
https://doi.org/10.1016/j.tetlet.2008.03.134
https://doi.org/10.1016/j.tetlet.2008.03.134
Autor:
Rainer Schobert, Thomas Mueller, Andrea Dietrich, Bernd Kalinowski, Reinhard Paschke, Bernhard Biersack, Miroslava Zoldakova
Publikováno v:
Journal of inorganic biochemistry. 105(12)
A series of dichloridoplatinum(II) complexes with selective and high cytotoxicity [IC 90 (96 h) ≤ 3 μM] against cisplatin-resistant 1411HP testicular cancer cells were identified. They bear stationary 6-aminomethylnicotinate or 2,4-diaminobutyrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::266a79ffa9a7a5afa79f750adf282c18
https://pubmed.ncbi.nlm.nih.gov/22071088
https://pubmed.ncbi.nlm.nih.gov/22071088
Autor:
Andreas Brown, Zsuzsanna Környei, Rainer Schobert, Bernhard Biersack, Miroslava Zoldakova, Emília Madarász
Publikováno v:
Biochemical pharmacology. 80(10)
The combretastatin A4 analogous chalcone (2E)-3-(3-hydroxy-4-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one 1 and its dichloridoplatinum(II) (6-aminomethylnicotinate) complex 2 were previously found to be highly active against a variety of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2017bf2d631e2818adcc875b65847dc1
https://pubmed.ncbi.nlm.nih.gov/20709029
https://pubmed.ncbi.nlm.nih.gov/20709029
Autor:
Sebastian Knauer, Katharina Effenberger, Bernhard Biersack, Miroslava Zoldakova, Wolfgang Milius, Rainer Schobert
Publikováno v:
Anti-cancer drugs. 20(8)
The unfavorable therapeutic index of the fungal cytotoxin illudin M was to be improved by covalent attachment of the redox modulator and phenyl isobiostere ferrocene. Esters of illudin M with ferrocenoic and 1,1'-ferrocenedioic acid were prepared, st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e01fd6080460e32143a575f8fbff7b34
https://pubmed.ncbi.nlm.nih.gov/19606019
https://pubmed.ncbi.nlm.nih.gov/19606019
Autor:
Bernhard Biersack, Angelika Fruehauf, Thomas Mueller, Miroslava Zoldakova, Rainer Schobert, Sebastian Knauer, Andrea Dietrich
Publikováno v:
Journal of medicinal chemistry. 52(2)
Three dichlorido(6-aminomethylnicotinate)platinum complexes 6 comprising a combretastatin A-4 analogous chalcone were tested on a panel of 21 tumor cell lines from 9 entities. Parent chalcone 1a and the directly linked conjugate 6a exhibited excellen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eaa48fed78994593446d43e3e0f8c32
https://pubmed.ncbi.nlm.nih.gov/19102652
https://pubmed.ncbi.nlm.nih.gov/19102652
Publikováno v:
Chemistrybiodiversity. 5(8)
Twenty-eight [6-(aminomethyl)nicotinate]dichloridoplatinum(II) complexes 1 esterified with various terpene alcohols either directly or via alkyl spacers were tested for antiproliferative activity in human 518A2 melanoma and HL-60 leukemia cells. Gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dd055a642dbbac25a07d72fc3c557ba
https://pubmed.ncbi.nlm.nih.gov/18729100
https://pubmed.ncbi.nlm.nih.gov/18729100
Autor:
Fazlul H. Sarkar, Hana Kostrhunova, Miroslava Zoldakova, Viktor Brabec, Aamir Ahmad, Rainer Schobert, Subhash Padhye, Bernhard Biersack
Publikováno v:
MedChemComm. 2:493
The combretastatin A-4 analogue m-hydroxychalcone 2 was esterified with a (1-carboxyethane-2,3-diamine)dichloridoplatinum(II) fragment to give complex 6 which was more active against various cancer cell lines (IC50 < 1 µM) than its analogue 3 bearin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c64f1381fc5d141259bb42e4add15484
https://doi.org/10.1039/c1md00042j
https://doi.org/10.1039/c1md00042j