Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Miroslava Cuperlovic"'
Autor:
Miroslava Cuperlovic-Culf, Steffany A.L. Bennett, Yannick Galipeau, Pauline S. McCluskie, Corey Arnold, Salman Bagheri, Curtis L. Cooper, Marc-André Langlois, Jörg H. Fritz, Ciriaco A. Piccirillo, Angela M. Crawley
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110484- (2024)
Summary: Prevention of negative COVID-19 infection outcomes is associated with the quality of antibody responses, whose variance by age and sex is poorly understood. Network approaches identified sex and age effects in antibody responses and neutrali
Externí odkaz:
https://doaj.org/article/518eeac978cf4cdfb3505928c36ddd3d
Autor:
Michel N. Kanaan, Chantal A. Pileggi, Charbel Y. Karam, Luke S. Kennedy, Claire Fong-McMaster, Miroslava Cuperlovic-Culf, Mary-Ellen Harper
Publikováno v:
Redox Biology, Vol 73, Iss , Pp 103213- (2024)
Cysteine, the rate-controlling amino acid in cellular glutathione synthesis is imported as cystine, by the cystine/glutamate antiporter, xCT, and subsequently reduced to cysteine. As glutathione redox is important in muscle regeneration in aging, we
Externí odkaz:
https://doaj.org/article/d63665a9bcdb4a1697b39515309c5096
Autor:
Chantal A. Pileggi, Gaganvir Parmar, Hussein Elkhatib, Corina M. Stewart, Irina Alecu, Marceline Côté, Steffany A.L. Bennett, Jagdeep K. Sandhu, Miroslava Cuperlovic-Culf, Mary-Ellen Harper
Publikováno v:
Current Research in Neurobiology, Vol 5, Iss , Pp 100112- (2023)
SARS-CoV-2 infection is associated with both acute and post-acute neurological symptoms. Emerging evidence suggests that SARS-CoV-2 can alter mitochondrial metabolism, suggesting that changes in brain metabolism may contribute to the development of a
Externí odkaz:
https://doaj.org/article/a8e55941bb8b418f8beb33198757c62a
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-17 (2021)
Abstract Background Direct link between metabolism and cell and organism phenotype in health and disease makes metabolomics, a high throughput study of small molecular metabolites, an essential methodology for understanding and diagnosing disease dev
Externí odkaz:
https://doaj.org/article/0d068470168c430eb89d0f55abad981a
Autor:
Miroslava Cuperlovic-Culf, Emma L. Cunningham, Hossen Teimoorinia, Anuradha Surendra, Xiaobei Pan, Steffany A. L. Bennett, Mijin Jung, Bernadette McGuiness, Anthony Peter Passmore, David Beverland, Brian D. Green
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Delirium is an acute change in attention and cognition occurring in ~ 65% of severe SARS-CoV-2 cases. It is also common following surgery and an indicator of brain vulnerability and risk for the development of dementia. In this work we analy
Externí odkaz:
https://doaj.org/article/4df6d3296fd944089207c388aeb2a432
Autor:
Mathieu Johnson, Sarah Nowlan, Gülsüm Sahin, David A. Barnett, Andrew P. Joy, Mohamed Touaibia, Miroslava Cuperlovic-Culf, Daina Zofija Avizonis, Sandra Turcotte
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Kidney cancer is one of the top ten cancer diagnosed worldwide and its incidence has increased the last 20 years. Clear Cell Renal Cell Carcinoma (ccRCC) are characterized by mutations that inactivate the von Hippel-Lindau (VHL) tumor suppressor gene
Externí odkaz:
https://doaj.org/article/5f3d652ddd3a49e68bd3850cf9d62e57
Publikováno v:
Bioengineering, Vol 10, Iss 2, p 229 (2023)
Recombinant adeno-associated virus (rAAV) is the most effective viral vector technology for directly translating the genomic revolution into medicinal therapies. However, the manufacturing of rAAV viral vectors remains challenging in the upstream pro
Externí odkaz:
https://doaj.org/article/a9c8919bb4864cc6980ecb5ce98f2026
Autor:
Yannick Galipeau, Vinayakumar Siragam, Geneviève Laroche, Erika Marion, Matthew Greig, Michaeline McGuinty, Ronald A Booth, Yves Durocher, Miroslava Cuperlovic-Culf, Steffany A.L. Bennett, Angela M. Crawley, Patrick M. Giguère, Curtis Cooper, Marc-André Langlois
Publikováno v:
EBioMedicine, Vol 74, Iss , Pp 103700- (2021)
Background: Antibodies raised against human seasonal coronaviruses (sCoVs), which are responsible for the common cold, are known to cross-react with SARS-CoV-2 antigens. This prompts questions about their protective role against SARS-CoV-2 infections
Externí odkaz:
https://doaj.org/article/7ba81d4ec8dc43269394d064eb78b2d7
Autor:
Filip Stojanovic, Mariam Taktek, Nam Huan Khieu, Junzhou Huang, Susan Jiang, Kerry Rennie, Balu Chakravarthy, Will J Costain, Miroslava Cuperlovic-Culf
Publikováno v:
PLoS ONE, Vol 16, Iss 5, p e0250568 (2021)
The development of effective therapies as well as early, molecular diagnosis of Alzheimer's disease is impeded by the lack of understanding of the underlying pathological mechanisms. Metabolomics studies of body fluids as well as brain tissues have s
Externí odkaz:
https://doaj.org/article/7ca410966c494c238d0e4caf8e431b64
Publikováno v:
Applied Sciences, Vol 11, Iss 6, p 2692 (2021)
Accurate and efficient segmentation of live-cell images is critical in maximizing data extraction and knowledge generation from high-throughput biology experiments. Despite recent development of deep-learning tools for biomedical imaging applications
Externí odkaz:
https://doaj.org/article/5fda3203387a4eebbf1ff2b106ac29b8