Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Miroslav Varecha"'
Autor:
Michaela Bosakova, Sara P Abraham, Alexandru Nita, Eva Hruba, Marcela Buchtova, S Paige Taylor, Ivan Duran, Jorge Martin, Katerina Svozilova, Tomas Barta, Miroslav Varecha, Lukas Balek, Jiri Kohoutek, Tomasz Radaszkiewicz, Ganesh V Pusapati, Vitezslav Bryja, Eric T Rush, Isabelle Thiffault, Deborah A Nickerson, Michael J Bamshad, University of Washington Center for Mendelian Genomics, Rajat Rohatgi, Daniel H Cohn, Deborah Krakow, Pavel Krejci
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 11, Pp 1-20 (2020)
Abstract Mutations in genes affecting primary cilia cause ciliopathies, a diverse group of disorders often affecting skeletal development. This includes Jeune syndrome or asphyxiating thoracic dystrophy (ATD), an autosomal recessive skeletal disorder
Externí odkaz:
https://doaj.org/article/83076ddc0da44600bc5e023ad4e46b45
Autor:
Iva Gudernova, Silvie Foldynova-Trantirkova, Barbora El Ghannamova, Bohumil Fafilek, Miroslav Varecha, Lukas Balek, Eva Hruba, Lucie Jonatova, Iva Jelinkova, Michaela Kunova Bosakova, Lukas Trantirek, Jiri Mayer, Pavel Krejci
Publikováno v:
eLife, Vol 6 (2017)
In-cell profiling enables the evaluation of receptor tyrosine activity in a complex environment of regulatory networks that affect signal initiation, propagation and feedback. We used FGF-receptor signaling to identify EGR1 as a locus that strongly r
Externí odkaz:
https://doaj.org/article/163ec228390542f9aefa419a66246f0b
Autor:
Tomáš Zikmund, Miroslav Varecha, Maria Hovorakova, Michaela Kavkova, Pavel Krejci, Linda Dalecka, Marcela Buchtová, Jozef Kaiser, Eva Hrubá, Miloš Macholán, Michaela Bosakova
Publikováno v:
Journal of Bone and Mineral Research. 36:2258-2274
The Sprouty family is a highly conserved group of intracellular modulators of receptor tyrosine kinase (RTK)-signaling pathways, which have been recently linked to primary cilia. Disruptions in the structure and function of primary cilia cause inheri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1201f537862320187e827407fc38c275
https://doi.org/10.1002/jbmr.4427
https://doi.org/10.1002/jbmr.4427
Autor:
Bohumil Fafilek, Peter Konik, Iva Gudernova, Jennifer Zieba, Miroslav Varecha, Sara P. Abraham, Tomas Gregor, Ivan Duran, David Šmajs, Gert Jansen, Marketa Tomanova, Pavel Krejci, So Hyun Park, Jieun Song, Tomáš Bárta, Deborah Krakow, Lukas Balek, Alexandru Nita, David Potesil, Zheng Fu, Neha Basheer, Hyuk Wan Ko, Aleš Hampl, Michaela Bosakova, Jana Kučerová, Juraj Bosák, Lukáš Trantírek, Zbynek Zdrahal
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the U.S.A., 116(10), 4316-4325. National Academy of Sciences
Proceedings of the National Academy of Sciences of the U.S.A., 116(10), 4316-4325. National Academy of Sciences
Significance A properly functioning primary cilium is prerequisite for both normal development and aging of all ciliated organisms, including humans. In vertebrates, the signaling of Hedgehog family morphogens depends entirely on primary cilium. Rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::837d1a7db436aa04d141b528ac31c912
http://europepmc.org/articles/PMC6410813
http://europepmc.org/articles/PMC6410813
Autor:
Lukáš Trantírek, Stjepan Uldrijan, Bohumil Fafilek, Michaela Bosakova, Pavel Krejci, Miroslav Varecha, Veronika Palušová, Jana Kučerová, Lukas Balek, Iva Gudernova
Publikováno v:
Oncotarget
Many tyrosine kinase inhibitors (TKIs) have failed to reach human use due to insufficient activity in clinical trials. However, the failed TKIs may still benefit patients if their other kinase targets are identified by providing treatment focused on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::224b9a77a6b30c6b6ee71f379301bdc6
https://doi.org/10.18632/oncotarget.22674
https://doi.org/10.18632/oncotarget.22674
Autor:
Miroslav Varecha, Vladimír Rotrekl, Michaela Bosakova, Giuseppe La Venuta, Pavel Krejci, Petr Dvorak, Zaneta Konecna, Karolina Zoufalova, Tereza Vanova, Zuzana Zbonakova, Walter Nickel, Šárka Jelínková
Publikováno v:
Stem Cells. 35:2050-2059
Human pluripotent stem cells (hPSC) require signaling provided by fibroblast growth factor (FGF) receptors. This can be initiated by the recombinant FGF2 ligand supplied exogenously, but hPSC further support their niche by secretion of endogenous FGF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb959d19123f9fd94373a33e0e0e9e81
https://doi.org/10.1002/stem.2660
https://doi.org/10.1002/stem.2660
Autor:
Marcela Buchtová, Jiri Kohoutek, Ganesh V. Pusapati, Katerina Svozilova, Isabelle Thiffault, Ivan Duran, Lukas Balek, Pavel Krejci, Sara P. Abraham, Michael J. Bamshad, Daniel H. Cohn, Deborah Krakow, Michaela Bosakova, S. Paige Taylor, Tomáš Bárta, Deborah A. Nickerson, Vitezslav Bryja, Tomasz Witold Radaszkiewicz, Eva Hrubá, Eric T. Rush, Miroslav Varecha, Alexandru Nita, Rajat Rohatgi, Jorge H. Martin
Publikováno v:
EMBO Molecular Medicine
EMBO Molecular Medicine, Vol 12, Iss 11, Pp n/a-n/a (2020)
EMBO Molecular Medicine, Vol 12, Iss 11, Pp n/a-n/a (2020)
Mutations in genes affecting primary cilia cause ciliopathies, a diverse group of disorders often affecting skeletal development. This includes Jeune syndrome or asphyxiating thoracic dystrophy (ATD), an autosomal recessive skeletal disorder. Unravel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::208e6515d54d4288226d733a8d34fa33
https://pubmed.ncbi.nlm.nih.gov/33200460
https://pubmed.ncbi.nlm.nih.gov/33200460
Autor:
Iva Vesela, Lukáš Trantírek, Stuart Turner, Miroslav Varecha, Iva Gudernova, Silvie Foldynová-Trantírková, Petr Cigler, Marcela Buchtová, Michaela Bosakova, Jan Havlik, Lars Klimaschewski, Pavel Krejci, Peter Claus, Malgorzata Zakrzewska, Lukas Balek, Mateusz Adam Krzyscik, Jitka Neburkova
Publikováno v:
Biomaterials
The blocking of specific protein-protein interactions using nanoparticles is an emerging alternative to small molecule-based therapeutic interventions. However, the nanoparticles designed as "artificial proteins" generally require modification of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1142f37379d9740624cb785d12bead2
https://hdl.handle.net/10067/1523770151162165141
https://hdl.handle.net/10067/1523770151162165141
Autor:
Jennifer Zieba, Bohumil Fafilek, Miroslav Varecha, Nicole H. Cernohorsky, Lukáš Trantírek, Iva Gudernova, Alexandru Nita, Jørgen Wesche, Lucie Jonatova, Christophe Erneux, Ellen Margrethe Haugsten, Tomas Gregor, Pavel Krejci, Jitka Krenova, Martin Piskacek, Lukas Balek, Michaela Bosakova, Somadri Ghosh, Deborah Krakow, Michal Kostas
Sustained activation of extracellular signal-regulated kinase (ERK) drives pathologies caused by mutations in fibroblast growth factor receptors (FGFRs). We previously identified the inositol phosphatase SHIP2 (also known as INPPL1) as an FGFR-intera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9596a5217adb24417e9463b09d8bd9a
http://hdl.handle.net/10852/72447
http://hdl.handle.net/10852/72447
Autor:
Marcela Buchtová, Miroslav Varecha, Pavel Krejci, Jorge H. Martin, Zhenhong Ni, Alexandru Nita, Hana Dosedelova, Radek Machat, Michaela Bosakova, Deborah Krakow, Gert Jansen, Yangli Xie, Ivan Duran, Marek Hampl, Lin Chen
Publikováno v:
Human Molecular Genetics, 27(6), 1093-1105. Oxford University Press
Cilia project from almost every cell integrating extracellular cues with signaling pathways. Constitutive activation of FGFR3 signaling produces the skeletal disorders achondroplasia (ACH) and thanatophoric dysplasia (TD), but many of the molecular m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a1a759f0a7ed0d7a755b52e790e198b
https://pure.eur.nl/en/publications/b5974e06-cf21-4171-ada6-c69993c6f105
https://pure.eur.nl/en/publications/b5974e06-cf21-4171-ada6-c69993c6f105