Výsledky vyhledávání - "Miroslav Smola"

Akademický článek

Convergent evolution in the mechanisms of ACBD3 recruitment to picornavirus replication sites.

Autor: Vladimira Horova, Heyrhyoung Lyoo, Bartosz Różycki, Dominika Chalupska, Miroslav Smola, Jana Humpolickova, Jeroen R P M Strating, Frank J M van Kuppeveld, Evzen Boura, Martin Klima

Publikováno v: PLoS Pathogens, Vol 15, Iss 8, p e1007962 (2019)

Enteroviruses, members of the family of picornaviruses, are the most common viral infectious agents in humans causing a broad spectrum of diseases ranging from mild respiratory illnesses to life-threatening infections. To efficiently replicate within

Externí odkaz: https://doaj.org/article/3c595b6221a645c7b30fb60a680283a1

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Design, Synthesis, and Biochemical and Biological Evaluation of Novel 7-Deazapurine Cyclic Dinucleotide Analogues as STING Receptor Agonists

Autor: Zdeněk Vavřina, Pavla Perlíková, Nemanja Milisavljević, Florian Chevrier, Miroslav Smola, Joshua Smith, Milan Dejmek, Vojtěch Havlíček, Miloš Buděšínský, Radek Liboska, Lenka Vaneková, Jiří Brynda, Evzen Boura, Pavlína Řezáčová, Michal Hocek, Gabriel Birkuš

Publikováno v: Journal of Medicinal Chemistry. 65:14082-14103

Cyclic dinucleotides (CDNs) are second messengers that activate stimulator of interferon genes (STING). The cGAS-STING pathway plays a promising role in cancer immunotherapy. Here, we describe the synthesis of CDNs containing 7-substituted 7-deazapur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bc699db0a58f8c3583118679a461959
https://doi.org/10.1021/acs.jmedchem.2c01305

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Synthesis and Biological Evaluation of Phosphoester and Phosphorothioate Prodrugs of STING Agonist 3′,3′-c-Di(2′F,2′dAMP)

Autor: Gabriel Birkus, Miroslav Smola, Petra Břehová, Lubomír Rulíšek, Martin Maxmilian Kaiser, Michal Šála, Aleš Marek, Martin Dračínský, Andrea Brázdová, Barbora Novotna, Zlatko Janeba, Milan Dejmek, Joshua R. Smith, Markéta Pimková Polidarová, Radim Nencka, Ondřej Páv, Evzen Boura, Ondrej Gutten

Publikováno v: Journal of Medicinal Chemistry. 64:7596-7616

Cyclic dinucleotides (CDNs) are second messengers that bind to the stimulator of interferon genes (STING) and trigger the expression of type I interferons and proinflammatory cytokines. Here we evaluate the activity of 3',3'-c-di(2'F,2'dAMP) and its

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::583c7c8621ad313e02166230b7d6d0b2
https://doi.org/10.1021/acs.jmedchem.1c00301

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Ligand Strain and Its Conformational Complexity Is a Major Factor in the Binding of Cyclic Dinucleotides to STING Protein

Autor: Miroslav Smola, Ondrej Gutten, Milan Dejmek, Milan Kožíšek, Thomas Evangelidis, Zahra Aliakbar Tehrani, Barbora Novotná, Radim Nencka, Gabriel Birkuš, Lubomír Rulíšek, Evzen Boura

Publikováno v: Angewandte Chemie (International Ed. in English)

STING (stimulator of interferon genes) is a key regulator of innate immunity that has recently been recognized as a promising drug target. STING is activated by cyclic dinucleotides (CDNs) which eventually leads to expression of type I interferons an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eee445ddb3d2d83a85e47330275e3e4
https://doi.org/10.1002/anie.202016805

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Protein–Ligand Interactions in the STING Binding Site Probed by Rationally Designed Single-Point Mutations: Experiment and Theory

Autor: Miroslav Smola, Martin Zavřel, Gabriel Birkus, Vilém Charvát, Milan Kožíšek, Ondrej Gutten, Zahra Aliakbar Tehrani, Lubomír Rulíšek, Zdeněk Vavřina, Evzen Boura

Publikováno v: Biochemistry. 60:607-620

STING protein (stimulator of interferon genes) plays an important role in the innate immune system. A number of potent compounds regulating its activity have been reported, mostly derivatives of cyclic dinucleotides (CDNs), natural STING agonists. He

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8fcfa42287fa3c027f0680e8901d29b
https://doi.org/10.1021/acs.biochem.0c00949

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Enzymatic Synthesis of 3'-5', 3'-5' Cyclic Dinucleotides, Their Binding Properties to the Stimulator of Interferon Genes Adaptor Protein, and Structure/Activity Correlations

Autor: Florian Chevrier, Monika Staś, Radek Liboska, Miroslav Smola, Lucie Holá, Evzen Boura, Ondrej Gutten, Martin Zavřel, Lubomír Rulíšek, Barbora Novotna, Zdeněk Vavřina, Juraj Dobiaš, Gabriel Birkus, Miloš Buděšínský

Publikováno v: Biochemistry. 60(48)

The 3'-5', 3'-5' cyclic dinucleotides (3'3'CDNs) are bacterial second messengers that can also bind to the stimulator of interferon genes (STING) adaptor protein in vertebrates and activate the host innate immunity. Here, we profiled the substrate sp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::566fa9e8b67f54b6682fc1b1daaf0b02
https://pubmed.ncbi.nlm.nih.gov/34788017

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Discovery of isonucleotidic CDNs as potent STING agonists with immunomodulatory potential

Autor: Milan Dejmek, Michal Šála, Andrea Brazdova, Lenka Vanekova, Miroslav Smola, Martin Klíma, Petra Břehová, Miloš Buděšínský, Martin Dračínský, Eliška Procházková, Martin Zavřel, Ondřej Šimák, Ondřej Páv, Evzen Boura, Gabriel Birkuš, Radim Nencka

Publikováno v: Structure. 30:1146-1156.e11

Stimulator of interferon genes (STING) is an adaptor protein of the cGAS-STING signaling pathway involved in the sensing of cytosolic DNA. It functions as a receptor for cyclic dinucleotides (CDNs) and, upon their binding, mediates cytokine expressio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab39906c104f0aa94e63901ec65433c4
https://doi.org/10.1016/j.str.2022.05.012

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Enzymatic Preparation of 2'-5',3'-5'-Cyclic Dinucleotides, Their Binding Properties to Stimulator of Interferon Genes Adaptor Protein, and Structure/Activity Correlations

Publikováno v: Journal of medicinal chemistry. 62(23)

Cyclic dinucleotides are second messengers in the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway, which plays an important role in recognizing tumor cells and viral or bacterial infections. They bind to the STING adapto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39fa918f39b01eb21b81b75407db4916
https://pubmed.ncbi.nlm.nih.gov/31715099

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Structural basis for hijacking of the host ACBD3 protein by bovine and porcine enteroviruses and kobuviruses

Autor: Evzen Boura, Miroslav Smola, Vladimira Horova, Martin Klima

Publikováno v: Archives of virology. 165(2)

Picornaviruses infect a wide range of mammals including livestock such as cattle and swine. As with other picornavirus genera such as Aphthovirus, there is emerging evidence of a significant economic impact of livestock infections caused by members o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85d691d82bf01e0414e8f733686109ad
https://pubmed.ncbi.nlm.nih.gov/31845156

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No magnesium is needed for binding of the stimulator of interferon genes to cyclic dinucleotides

Autor: Miroslav Smola, Evzen Boura, Gabriel Birkus

Publikováno v: Acta Crystallogr F Struct Biol Commun

Stimulator of interferon genes (STING) binds cyclic dinucleotides (CDNs), which induce a large conformational change of the protein. The structural basis of activation of STING by CDNs is rather well understood. Unliganded STING forms an open dimer t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d5219a367e507a6bbb54ca1a0348682
https://pubmed.ncbi.nlm.nih.gov/31475926

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