Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Miroslav Smola"'
Autor:
Vladimira Horova, Heyrhyoung Lyoo, Bartosz Różycki, Dominika Chalupska, Miroslav Smola, Jana Humpolickova, Jeroen R P M Strating, Frank J M van Kuppeveld, Evzen Boura, Martin Klima
Publikováno v:
PLoS Pathogens, Vol 15, Iss 8, p e1007962 (2019)
Enteroviruses, members of the family of picornaviruses, are the most common viral infectious agents in humans causing a broad spectrum of diseases ranging from mild respiratory illnesses to life-threatening infections. To efficiently replicate within
Externí odkaz:
https://doaj.org/article/3c595b6221a645c7b30fb60a680283a1
Autor:
Zdeněk Vavřina, Pavla Perlíková, Nemanja Milisavljević, Florian Chevrier, Miroslav Smola, Joshua Smith, Milan Dejmek, Vojtěch Havlíček, Miloš Buděšínský, Radek Liboska, Lenka Vaneková, Jiří Brynda, Evzen Boura, Pavlína Řezáčová, Michal Hocek, Gabriel Birkuš
Publikováno v:
Journal of Medicinal Chemistry. 65:14082-14103
Cyclic dinucleotides (CDNs) are second messengers that activate stimulator of interferon genes (STING). The cGAS-STING pathway plays a promising role in cancer immunotherapy. Here, we describe the synthesis of CDNs containing 7-substituted 7-deazapur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bc699db0a58f8c3583118679a461959
https://doi.org/10.1021/acs.jmedchem.2c01305
https://doi.org/10.1021/acs.jmedchem.2c01305
Autor:
Gabriel Birkus, Miroslav Smola, Petra Břehová, Lubomír Rulíšek, Martin Maxmilian Kaiser, Michal Šála, Aleš Marek, Martin Dračínský, Andrea Brázdová, Barbora Novotna, Zlatko Janeba, Milan Dejmek, Joshua R. Smith, Markéta Pimková Polidarová, Radim Nencka, Ondřej Páv, Evzen Boura, Ondrej Gutten
Publikováno v:
Journal of Medicinal Chemistry. 64:7596-7616
Cyclic dinucleotides (CDNs) are second messengers that bind to the stimulator of interferon genes (STING) and trigger the expression of type I interferons and proinflammatory cytokines. Here we evaluate the activity of 3',3'-c-di(2'F,2'dAMP) and its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::583c7c8621ad313e02166230b7d6d0b2
https://doi.org/10.1021/acs.jmedchem.1c00301
https://doi.org/10.1021/acs.jmedchem.1c00301
Autor:
Miroslav Smola, Ondrej Gutten, Milan Dejmek, Milan Kožíšek, Thomas Evangelidis, Zahra Aliakbar Tehrani, Barbora Novotná, Radim Nencka, Gabriel Birkuš, Lubomír Rulíšek, Evzen Boura
Publikováno v:
Angewandte Chemie (International Ed. in English)
STING (stimulator of interferon genes) is a key regulator of innate immunity that has recently been recognized as a promising drug target. STING is activated by cyclic dinucleotides (CDNs) which eventually leads to expression of type I interferons an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eee445ddb3d2d83a85e47330275e3e4
https://doi.org/10.1002/anie.202016805
https://doi.org/10.1002/anie.202016805
Autor:
Miroslav Smola, Martin Zavřel, Gabriel Birkus, Vilém Charvát, Milan Kožíšek, Ondrej Gutten, Zahra Aliakbar Tehrani, Lubomír Rulíšek, Zdeněk Vavřina, Evzen Boura
Publikováno v:
Biochemistry. 60:607-620
STING protein (stimulator of interferon genes) plays an important role in the innate immune system. A number of potent compounds regulating its activity have been reported, mostly derivatives of cyclic dinucleotides (CDNs), natural STING agonists. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8fcfa42287fa3c027f0680e8901d29b
https://doi.org/10.1021/acs.biochem.0c00949
https://doi.org/10.1021/acs.biochem.0c00949
Autor:
Florian Chevrier, Monika Staś, Radek Liboska, Miroslav Smola, Lucie Holá, Evzen Boura, Ondrej Gutten, Martin Zavřel, Lubomír Rulíšek, Barbora Novotna, Zdeněk Vavřina, Juraj Dobiaš, Gabriel Birkus, Miloš Buděšínský
Publikováno v:
Biochemistry. 60(48)
The 3'-5', 3'-5' cyclic dinucleotides (3'3'CDNs) are bacterial second messengers that can also bind to the stimulator of interferon genes (STING) adaptor protein in vertebrates and activate the host innate immunity. Here, we profiled the substrate sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::566fa9e8b67f54b6682fc1b1daaf0b02
https://pubmed.ncbi.nlm.nih.gov/34788017
https://pubmed.ncbi.nlm.nih.gov/34788017
Autor:
Zahra Aliakbar Tehrani, Martin Zavřel, Tomáš Jandušík, Andrea Brázdová, Ondrej Gutten, Radim Nencka, Gabriel Birkus, Miloš Buděšínský, Ondřej Páv, Evžen Bouřa, Markéta Pimková Polidarová, Barbora Novotna, Radek Liboska, Zdeněk Vavřina, Milan Dejmek, Miroslav Smola, Jiří Brynda, Ivan Štěpánek, Lubomír Rulíšek, Lenka Vaneková
Publikováno v:
Journal of medicinal chemistry. 62(23)
Cyclic dinucleotides are second messengers in the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway, which plays an important role in recognizing tumor cells and viral or bacterial infections. They bind to the STING adapto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39fa918f39b01eb21b81b75407db4916
https://pubmed.ncbi.nlm.nih.gov/31715099
https://pubmed.ncbi.nlm.nih.gov/31715099
Publikováno v:
Archives of virology. 165(2)
Picornaviruses infect a wide range of mammals including livestock such as cattle and swine. As with other picornavirus genera such as Aphthovirus, there is emerging evidence of a significant economic impact of livestock infections caused by members o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85d691d82bf01e0414e8f733686109ad
https://pubmed.ncbi.nlm.nih.gov/31845156
https://pubmed.ncbi.nlm.nih.gov/31845156
Publikováno v:
Acta Crystallogr F Struct Biol Commun
Stimulator of interferon genes (STING) binds cyclic dinucleotides (CDNs), which induce a large conformational change of the protein. The structural basis of activation of STING by CDNs is rather well understood. Unliganded STING forms an open dimer t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d5219a367e507a6bbb54ca1a0348682
https://pubmed.ncbi.nlm.nih.gov/31475926
https://pubmed.ncbi.nlm.nih.gov/31475926
Autor:
Eva Zborníková, Milan Dejmek, Miroslav Smola, Jaroslav Kozák, Hubert Hřebabecký, Michal Šála, Daniel Ruzek, Evzen Boura, Radim Nencka, Kamil Hercik
Publikováno v:
Antiviral Research. 137:131-133
We describe the expression and purification of an active recombinant Zika virus RNA-dependent RNA polymerase (RdRp). Next, we present the development and optimization of an in vitro assay to measure its activity. We then applied the assay to selected
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b6abb5a170b546df8effb19cfacb927
https://doi.org/10.1016/j.antiviral.2016.11.020
https://doi.org/10.1016/j.antiviral.2016.11.020