Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Miroslav Havránek"'
Autor:
Michael Kugler, Josef Holub, Jiří Brynda, Klára Pospíšilová, Suzan El Anwar, Dmytro Bavol, Miroslav Havránek, Vlastimil Král, Milan Fábry, Bohumír Grüner, Pavlína Řezáčová
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1800-1810 (2020)
Human carbonic anhydrase IX (CA IX), a protein specifically expressed on the surface of solid tumour cells, represents a validated target both for anticancer therapy and diagnostics. We recently identified sulfonamide dicarbaboranes as promising inhi
Externí odkaz:
https://doaj.org/article/4e570bd3c5e44b59a3ffde6f4d2e255b
Autor:
Miroslav Havránek, Maksim A. Samsonov, Josef Holub, Zdeňka Růžičková, Ladislav Drož, Aleš Růžička, Jindřich Fanfrlík, Drahomír Hnyk
Publikováno v:
Molecules, Vol 25, Iss 5, p 1200 (2020)
Although 1-Ph-2-X-closo-1,2-C2B10H10 (X = F, Cl, Br, I) derivatives had been computed to have positive values of the heat of formation, it was possible to prepare them. The corresponding solid-state structures were computationally analyzed. Electrost
Externí odkaz:
https://doaj.org/article/6ef3ad25e6734b33b74e0f75cbc2dbf1
Autor:
Miroslav Havránek, Zlatko Janeba, Ondřej Baszczyňski, Martin Maxmilian Kaiser, Viktor Kolman, Vladislav Kotek, Pavel Dosoudil
Publikováno v:
Organic Process Research & Development. 24:1718-1724
We report a scalable efficient synthesis of 5-butyl-4-(4-methoxyphenyl)-6-phenylpyrimidin-2-amine (WQE-134), a dual inhibitor of nitric oxide and prostaglandin E2 production with potent anti-inflam...
Autor:
Jiří Brynda, Pavlína Řezáčová, Suzan El Anwar, K. Pospisilova, Josef Holub, Milan Fábry, Dmytro Bavol, Miroslav Havránek, Vlastimil Král, M. Kugler, Bohumír Grüner
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1800-1810 (2020)
article-version (VoR) Version of Record
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1800-1810 (2020)
Human carbonic anhydrase IX (CA IX), a protein specifically expressed on the surface of solid tumour cells, represents a validated target both for anticancer therapy and diagnostics. We recently identified sulfonamide dicarbaboranes as promising inhi
Autor:
Viswanath Das, Jan Nekvinda, Jiří Brynda, K. Pospisilova, Marian Hajduch, Stanislava Matějková, Jana Dvořanová, Martina Medvedíková, Josef Holub, Soňa Gurská, Bohumír Grüner, Miroslav Havránek, Vlastimil Král, M. Kugler, Barbora Liskova, Pavlína Řezáčová, Suzan El Anwar, Václav Šícha, Milan Fábry, Petr Džubák
Publikováno v:
European journal of medicinal chemistry. 200
Carbonic anhydrase IX (CA IX) is a transmembrane enzyme overexpressed in hypoxic tumors, where it plays an important role in tumor progression. Specific CA IX inhibitors potentially could serve as anti-cancer drugs. We designed a series of sulfonamid
Autor:
Maksim A. Samsonov, Ladislav Drož, Josef Holub, Jindřich Fanfrlík, Zdeňka Růžičková, Drahomír Hnyk, Aleš Růžička, Miroslav Havránek
Publikováno v:
Molecules
Volume 25
Issue 5
Molecules, Vol 25, Iss 5, p 1200 (2020)
Volume 25
Issue 5
Molecules, Vol 25, Iss 5, p 1200 (2020)
Although 1-Ph-2-X-closo-1,2-C2B10H10 (X = F, Cl, Br, I) derivatives had been computed to have positive values of the heat of formation, it was possible to prepare them. The corresponding solid-state structures were computationally analyzed. Electrost
Publikováno v:
Ecological Indicators. 17:68-76
Economic activities often result in external costs which are not included in the current pricing system. Due to these external costs, the standard market mechanism fails to maximize social welfare. Therefore, it is necessary to provide decision maker
Autor:
Miroslav Havránek, Christopher Kennedy, Diane E. Pataki, Timothy Hillman, Barrie Gasson, Yvonne Hansen, Gara Villalba Méndez, Aumnad Phdungsilp, Anu Ramaswami, Julia K. Steinberger
Publikováno v:
Energy Policy. 38:4828-4837
This paper describes the methodology and data used to determine greenhouse gas (GHG) emissions attributable to ten cities or city-regions: Los Angeles County, Denver City and County, Greater Toronto, New York City, Greater London, Geneva Canton, Grea
Publikováno v:
Journal of Industrial Ecology. 11:140-154
Net additions to stock (NAS) are an indicator based on economy-wide material flow accounting and analysis. NAS, a measure of the physical growth rate of an economy, can be used for estimates of future waste flows. It is calculated using two methods:
Autor:
Miroslav Havránek, Dalimil Dvořák
Publikováno v:
Collection of Czechoslovak Chemical Communications. 65:434-454
Repeated Stille coupling of 3-substituted 3-(tributylstannyl)allyl alcohols 2 on a solid support was used to synthesize a 21 × 21 library of skipped dienes and a 21 × 21 × 21 library of skipped trienes. Starting 3-(tributylstannyl)allyl alcohols w