Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Miroslav Baláz"'
Autor:
Vissarion Efthymiou, Lianggong Ding, Miroslav Balaz, Wenfei Sun, Lucia Balazova, Leon G. Straub, Hua Dong, Eric Simon, Adhideb Ghosh, Aliki Perdikari, Svenja Keller, Umesh Ghoshdastider, Carla Horvath, Caroline Moser, Bradford Hamilton, Heike Neubauer, Christian Wolfrum
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract The current obesity epidemic and high prevalence of metabolic diseases necessitate efficacious and safe treatments. Brown adipose tissue in this context is a promising target with the potential to increase energy expenditure, however no phar
Externí odkaz:
https://doaj.org/article/ef281b42140141c1891ca96fd175d996
Autor:
Fabienne Gräbnitz, Dominique Stark, Danielle Shlesinger, Anthony Petkidis, Mariana Borsa, Alexander Yermanos, Andreas Carr, Niculò Barandun, Arne Wehling, Miroslav Balaz, Timm Schroeder, Annette Oxenius
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112468- (2023)
Summary: The strength of T cell receptor (TCR) stimulation and asymmetric distribution of fate determinants are both implied to affect T cell differentiation. Here, we uncover asymmetric cell division (ACD) as a safeguard mechanism for memory CD8 T c
Externí odkaz:
https://doaj.org/article/bcf275accd224424bf38dd9db79b0d8e
Autor:
Anand Kumar Sharma, Tongtong Wang, Alaa Othman, Radhika Khandelwal, Miroslav Balaz, Salvatore Modica, Nicola Zamboni, Christian Wolfrum
Publikováno v:
Molecular Metabolism, Vol 71, Iss , Pp 101701- (2023)
Objective: Emerging evidence suggest the existence of constant basal lipolysis and re-esterification of a substantial fraction of thus liberated fatty acids. In stimulated lipolysis, the re-esterification is proposed to be a protective mechanism agai
Externí odkaz:
https://doaj.org/article/bdf2274ead414c6d9fb369cfa8de1823
Autor:
Lucia Balazova, Miroslav Balaz, Carla Horvath, Áron Horváth, Caroline Moser, Zuzana Kovanicova, Adhideb Ghosh, Umesh Ghoshdastider, Vissarion Efthymiou, Elke Kiehlmann, Wenfei Sun, Hua Dong, Lianggong Ding, Ez-Zoubir Amri, Pirjo Nuutila, Kirsi A. Virtanen, Tarja Niemi, Barbara Ukropcova, Jozef Ukropec, Pawel Pelczar, Thorsten Lamla, Bradford Hamilton, Heike Neubauer, Christian Wolfrum
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Activation of thermogenic adipocytes is a strategy to combat metabolic diseases. Here the authors report that GPR180 is a component of TGFβ signalling that promotes thermogenic adipocyte function and mediates the metabolic effects of the adipocyte-s
Externí odkaz:
https://doaj.org/article/88ee4530cad64964a1bb8fbac9b2b659
Autor:
Mariana Borsa, Niculò Barandun, Fabienne Gräbnitz, Isabel Barnstorf, Nicolas S. Baumann, Katharina Pallmer, Samira Baumann, Dominique Stark, Miroslav Balaz, Nathalie Oetiker, Franziska Wagen, Christian Wolfrum, Anna Katharina Simon, Nicole Joller, Yves Barral, Roman Spörri, Annette Oxenius
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Asymmetrical cell division helps to maintain cellular heterogeneity in the T cell compartment. Here the authors examine the differential immune responses built by naive and virtual memory T cells from young and aged individuals, and explore the effec
Externí odkaz:
https://doaj.org/article/61aae8a737c543db8b183a3356289468
Autor:
Edwin E. G. W. ter Voert, Hanna Svirydenka, Julian Müller, Anton S. Becker, Miroslav Balaz, Vissarion Efthymiou, Claudia Irene Maushart, Gani Gashi, Christian Wolfrum, Matthias J. Betz, Irene A. Burger
Publikováno v:
EJNMMI Research, Vol 10, Iss 1, Pp 1-10 (2020)
Abstract Background Positron emission tomography (PET) is increasingly applied for in vivo brown adipose tissue (BAT) research in healthy volunteers. To limit the radiation exposure, the injected 18F-FDG tracer dose should be as low as possible. With
Externí odkaz:
https://doaj.org/article/9e6fd289156846fe868bb4a91518b05b
Autor:
Martina Felder, Claudia Irene Maushart, Gani Gashi, Jaël Rut Senn, Anton S. Becker, Julian Müller, Miroslav Balaz, Christian Wolfrum, Irene A. Burger, Matthias Johannes Betz
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
BackgroundStatins are commonly prescribed for primary and secondary prevention of atherosclerotic disease. They reduce cholesterol biosynthesis by inhibiting hydroxymethylglutaryl-coenzyme A-reductase (HMG-CoA-reductase) and therefore mevalonate synt
Externí odkaz:
https://doaj.org/article/1da85f4685ec4a61a5d809db33327698
Autor:
Timea Kurdiova, Miroslav Balaz, Zuzana Kovanicova, Erika Zemkova, Martin Kuzma, Vitazoslav Belan, Juraj Payer, Daniela Gasperikova, Hans Dieplinger, Barbara Ukropcova, Jozef Ukropec
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
AimAfamin is a liver-produced glycoprotein, a potential early marker of metabolic syndrome. Here we investigated regulation of afamin in a course of the metabolic disease development and in response to 3-month exercise intervention.MethodsWe measured
Externí odkaz:
https://doaj.org/article/9a3c6f9de5c04c54a5a41140c4b36c5e
Autor:
Claudia Irene Maushart, Jaël Rut Senn, Rahel Catherina Loeliger, Marius E. Kraenzlin, Julian Müller, Anton S. Becker, Miroslav Balaz, Christian Wolfrum, Irene A. Burger, Matthias Johannes Betz
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Thyroid hormone (TH) is an important regulator of mammalian metabolism and facilitates cold induced thermogenesis (CIT) in brown adipose tissue (BAT). Profound hypothyroidism or hyperthyroidism lead to alterations in BAT function and CIT. In euthyroi
Externí odkaz:
https://doaj.org/article/347d11e4c29f40fdba2113eb40920135
Autor:
Zuzana Kovaničová, Miloslav Karhánek, Tímea Kurdiová, Miroslav Baláž, Christian Wolfrum, Barbara Ukropcová, Jozef Ukropec
Publikováno v:
Metabolites, Vol 11, Iss 9, p 619 (2021)
Cold exposure results in activation of metabolic processes required for fueling thermogenesis, potentially promoting improved metabolic health. However, the metabolic complexity underlying this process is not completely understood. We aimed to analyz
Externí odkaz:
https://doaj.org/article/991bbe2d02ae4b3d95a2c4424b54dc2a