Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Miroslav, Psotka"'
Autor:
Xueqin Huang, Li You, Eugenie Nepovimova, Miroslav Psotka, David Malinak, Marian Valko, Ladislav Sivak, Jan Korabecny, Zbynek Heger, Vojtech Adam, Qinghua Wu, Kamil Kuca
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Phosphoinositide 3-kinases (PI3K) and phosphoinositide 3-kinase-related protein kinases (PIKK) are two structurally related families of kinases that play vital roles in cell growth and DNA damage repair. Dysfunction of PIKK members and aberrant stimu
Externí odkaz:
https://doaj.org/article/2625c42c0d07439f92419713efaf92ad
Autor:
Zuzana Kohoutova, David Malinak, Rudolf Andrys, Jana Svobodova, Miroslav Psotka, Monika Schmidt, Lukas Prchal, Kamil Musilek
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 760-767 (2022)
The organophosphorus antidotes, so-called oximes, are able to restore the enzymatic function of acetylcholinesterase (AChE) or butyrylcholinesterase (BChE) via cleavage of organophosphate from the active site of the phosphylated enzyme. In this work,
Externí odkaz:
https://doaj.org/article/d7105037e8584f718109d172295dd89d
Autor:
Patrik Oleksak, Miroslav Psotka, Marketa Vancurova, Olena Sapega, Jana Bieblova, Milan Reinis, David Rysanek, Romana Mikyskova, Katarina Chalupova, David Malinak, Jana Svobodova, Rudolf Andrys, Helena Rehulkova, Vojtech Skopek, Pham Ngoc Lam, Jiri Bartek, Zdenek Hodny, Kamil Musilek
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 410-424 (2021)
Twelve novel analogs of STAT3 inhibitor BP-1-102 were designed and synthesised with the aim to modify hydrophobic fragments of the molecules that are important for interaction with the STAT3 SH2 domain. The cytotoxic activity of the reference and nov
Externí odkaz:
https://doaj.org/article/cfac0c0e4320428ab38cfae14e7c28f8
Autor:
David Malinak, Rafael Dolezal, Vendula Hepnarova, Miroslava Hozova, Rudolf Andrys, Petr Bzonek, Veronika Racakova, Jan Korabecny, Lukas Gorecki, Eva Mezeiova, Miroslav Psotka, Daniel Jun, Kamil Kuca, Kamil Musilek
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 478-488 (2020)
The series of symmetrical and unsymmetrical isoquinolinium-5-carbaldoximes was designed and prepared for cholinesterase reactivation purposes. The novel compounds were evaluated for intrinsic acetylcholinesterase (AChE) or butyrylcholinesterase (BChE
Externí odkaz:
https://doaj.org/article/4eaa3b83e7db43c89b59bdfb119cb77b
Autor:
Alzbeta Filipova, Jan Marek, Radim Havelek, Jaroslav Pejchal, Marcela Jelicova, Jana Cizkova, Martina Majorosova, Lubica Muckova, Tomas Kucera, Lukas Prchal, Miroslav Psotka, Natalie Zivna, Darja Koutova, Zuzana Sinkorova, Martina Rezacova, Ales Tichy
Publikováno v:
Molecules, Vol 25, Iss 3, p 532 (2020)
The increasing risk of radiation exposure underlines the need for novel radioprotective agents. Hence, a series of novel 1-(2-hydroxyethyl)piperazine derivatives were designed and synthesized. Some of the compounds protected human cells against radia
Externí odkaz:
https://doaj.org/article/8e047d5c8c22403da51ebf57d1ca52df
Autor:
Daniel Jun, Eva Mezeiova, Rudolf Andrys, Jan Korabecny, Lukas Gorecki, Kamil Musilek, David Malinak, Miroslava Hozova, Veronika Racakova, Petr Bzonek, Kamil Kuca, Miroslav Psotka, Vendula Hepnarova, Rafael Dolezal
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 478-488 (2020)
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 478-488 (2020)
The series of symmetrical and unsymmetrical isoquinolinium-5-carbaldoximes was designed and prepared for cholinesterase reactivation purposes. The novel compounds were evaluated for intrinsic acetylcholinesterase (AChE) or butyrylcholinesterase (BChE
Autor:
Tamara Zorbaz, David Malinak, Tereza Hofmanova, Nikola Maraković, Suzana Žunec, Nikolina Maček Hrvat, Rudolf Andrys, Miroslav Psotka, Antonio Zandona, Jana Svobodova, Lukas Prchal, Sanja Fingler, Maja Katalinić, Zrinka Kovarik, Kamil Musilek
Publikováno v:
European Journal of Medicinal Chemistry. 238:114377
The fluorinated bis-pyridinium oximes were designed and synthesized with the aim of increasing their nucleophilicity and potential to reactivate phosphorylated human recombinant acetylcholinesterase (AChE) and human purified plasmatic butyrylcholines
Autor:
Patrik, Oleksak, Miroslav, Psotka, Marketa, Vancurova, Olena, Sapega, Jana, Bieblova, Milan, Reinis, David, Rysanek, Romana, Mikyskova, Katarina, Chalupova, David, Malinak, Jana, Svobodova, Rudolf, Andrys, Helena, Rehulkova, Vojtech, Skopek, Pham, Ngoc Lam, Jiri, Bartek, Zdenek, Hodny, Kamil, Musilek
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Twelve novel analogs of STAT3 inhibitor BP-1-102 were designed and synthesised with the aim to modify hydrophobic fragments of the molecules that are important for interaction with the STAT3 SH2 domain. The cytotoxic activity of the reference and nov
Autor:
David Malinak, Pham Ngoc Lam, Marketa Vancurova, Romana Mikyšková, Vojtech Skopek, Kamil Musilek, Jana Svobodova, Helena Rehulkova, Zdenek Hodny, Miroslav Psotka, Milan Reinis, Olena Sapega, Jiri Bartek, Katarina Chalupova, Rudolf Andrys, David Rysanek, Patrik Oleksak, Jana Bieblová
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 410-424 (2021)
Twelve novel analogs of STAT3 inhibitor BP-1-102 were designed and synthesised with the aim to modify hydrophobic fragments of the molecules that are important for interaction with the STAT3 SH2 domain. The cytotoxic activity of the reference and nov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8cac5c92173998608c522cc3e9dc3be
Autor:
Miroslav Psotka, Jaroslav Pejchal, Tomas Kucera, Zuzana Šinkorová, Ales Tichy, Natalie Zivna, Jana Cizkova, Marcela Jeličová, Alzbeta Filipova, Lubica Muckova, Darja Koutová, Lukas Prchal, Radim Havelek, Jan Marek, Martina Majorosova, Martina Rezacova
Publikováno v:
Molecules, Vol 25, Iss 3, p 532 (2020)
Molecules
Volume 25
Issue 3
Molecules
Volume 25
Issue 3
The increasing risk of radiation exposure underlines the need for novel radioprotective agents. Hence, a series of novel 1-(2-hydroxyethyl)piperazine derivatives were designed and synthesized. Some of the compounds protected human cells against radia