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Akademický článek
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Autor:
Zdenka, Sulová, Mário, Seres, Miroslav, Barancík, Lenka, Gibalová, Branislav, Uhrík, Lenka, Poleková, Albert, Breier
Publikováno v:
General physiology and biophysics.
Multidrug resistance (MDR) of neoplastic tissue represents a real obstacle to the effective chemotherapy of cancer. Several mechanisms of MDR were identified, from which the over-expression and efflux activity of P-glycoprotein (P-gp) - a plasma memb
Autor:
Ivana, Kupsáková, Alfons, Rybár, Peter, Docolomanský, Zuzana, Drobná, Ulrike, Stein, Wolfgang, Walther, Miroslav, Barancík, Albert, Breier
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 21(2-3)
In our previous papers we described the ability of methylxanthine pentoxifylline (PTX) to depress the P-glycoprotein (P-gp) mediated multidrug resistance (MDR) of the mouse leukemic cell line L1210/VCR. Other methylxanthines like caffeine and theophy
Publikováno v:
Molecular and cellular biochemistry. 247(1-2)
Eukaryotic cells respond to different external stimuli by activation of mechanisms of cell signaling. One of the major systems participating in the transduction of signal from the cell membrane to nuclear and other intracellular targets is the highly