Synthesis of fully functionalized spirostanic 1,2,3-triazoles by the three component reaction of diosgenin azides with acetophenones and aryl aldehydes and their biological evaluation as antiproliferative agents

Autor: Mironov, Maksim E., Rybalova, Tatyana V., Pokrovskii, Mikhail A., Emaminia, Fatemeh, Gandalipov, Erik R., Pokrovskii, Andrey G., Shults, Elvira E.

Publikováno v: In Steroids February 2023 190

Synthesis of Anti-Inflammatory Spirostene-Pyrazole Conjugates by a Consecutive Multicomponent Reaction of Diosgenin with Oxalyl Chloride, Arylalkynes and Hydrazines or Hydrazones.

Autor: Mironov ME; N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Academician Lavrentyev Ave., 9, 630090 Novosibirsk, Russia.; Department of Natural Sciences, Novosibirsk State University, Piragova Str., 1, 630090 Novosibirsk, Russia., Borisov SA; N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Academician Lavrentyev Ave., 9, 630090 Novosibirsk, Russia., Rybalova TV; N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Academician Lavrentyev Ave., 9, 630090 Novosibirsk, Russia., Baev DS; N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Academician Lavrentyev Ave., 9, 630090 Novosibirsk, Russia., Tolstikova TG; N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Academician Lavrentyev Ave., 9, 630090 Novosibirsk, Russia.; Department of Natural Sciences, Novosibirsk State University, Piragova Str., 1, 630090 Novosibirsk, Russia., Shults EE; N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Academician Lavrentyev Ave., 9, 630090 Novosibirsk, Russia.

Publikováno v: Molecules (Basel, Switzerland) [Molecules] 2021 Dec 28; Vol. 27 (1). Date of Electronic Publication: 2021 Dec 28.