Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Miro J. Eigenmann"'
Autor:
Jakob C. Stüber, Karin F. Rechberger, Saša M. Miladinović, Thomas Pöschinger, Tamara Zimmermann, Remi Villenave, Miro J. Eigenmann, Thomas E. Kraft, Dhaval K. Shah, Hubert Kettenberger, Wolfgang F. Richter
Publikováno v:
AAPS Open, Vol 8, Iss 1, Pp 1-18 (2022)
Abstract This study explores the impact of antibody surface charge on tissue distribution into various tissues including tumor. Tumor-bearing mice were dosed intravenously with a mixture comprising three antibodies engineered to carry negative charge
Externí odkaz:
https://doaj.org/article/7356f1aec7b84b8489b40eb563178c52
Presents the goodness of fit plots when fitting a 1-compartmental model to the short term PK data.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4a1a7345b2f913d983a647248bc8c90
https://doi.org/10.1158/1535-7163.22508385.v1
https://doi.org/10.1158/1535-7163.22508385.v1
Autor:
Antje-Christine Walz, Marina Bacac, Thorsten Lehr, Florian Limani, Sarah Diggelmann, Jitka Somandin, Regula B. Buser, Sylvia Herter, Nicolas Frances, Miro J. Eigenmann, Tina Weinzierl, Arthur J. Van De Vyver
Experimental data triplicate values with model fit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::236fc9f6a87241f542cdff136010e359
https://doi.org/10.1158/1535-7163.22521570.v1
https://doi.org/10.1158/1535-7163.22521570.v1
Autor:
Antje-Christine Walz, Marina Bacac, Thorsten Lehr, Florian Limani, Sarah Diggelmann, Jitka Somandin, Regula B. Buser, Sylvia Herter, Nicolas Frances, Miro J. Eigenmann, Tina Weinzierl, Arthur J. Van De Vyver
Targeted T-cell redirection is a promising field in cancer immunotherapy. T-cell bispecific antibodies (TCB) are novel antibody constructs capable of binding simultaneously to T cells and tumor cells, allowing cross-linking and the formation of immun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::660357c498b0b8984076522718e1e498
https://doi.org/10.1158/1535-7163.c.6543060
https://doi.org/10.1158/1535-7163.c.6543060
Autor:
Antje-Christine Walz, Marina Bacac, Thorsten Lehr, Florian Limani, Sarah Diggelmann, Jitka Somandin, Regula B. Buser, Sylvia Herter, Nicolas Frances, Miro J. Eigenmann, Tina Weinzierl, Arthur J. Van De Vyver
Estimated parameter values
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46ceb060b2ec8eb42fe870e1ca310382
https://doi.org/10.1158/1535-7163.22521552.v1
https://doi.org/10.1158/1535-7163.22521552.v1
Autor:
Antje-Christine Walz, Marina Bacac, Thorsten Lehr, Florian Limani, Sarah Diggelmann, Jitka Somandin, Regula B. Buser, Sylvia Herter, Nicolas Frances, Miro J. Eigenmann, Tina Weinzierl, Arthur J. Van De Vyver
Supplementary section S1 describes the compound properties of cibisatamab as well as details on data generation, model development and modeling strategy applied
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ce5d10b23066566fc8b27cf6312e8fe
https://doi.org/10.1158/1535-7163.22521558
https://doi.org/10.1158/1535-7163.22521558
Presents the estimated parameter values derived from the biomarker short term modeling.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdb89cdb7f73205465f3b474c7b65f62
https://doi.org/10.1158/1535-7163.22508370.v1
https://doi.org/10.1158/1535-7163.22508370.v1
Autor:
Florian Limani, Tina Weinzierl, Arthur J Van De Vyver, Marina Bacac, Thorsten Lehr, Nicolas Frances, Sarah Diggelmann, Miro J. Eigenmann, Regula B. Buser, Sylvia Herter, Antje-Christine Walz, Jitka Somandin
Publikováno v:
Molecular Cancer Therapeutics. 20:357-366
Targeted T-cell redirection is a promising field in cancer immunotherapy. T-cell bispecific antibodies (TCB) are novel antibody constructs capable of binding simultaneously to T cells and tumor cells, allowing cross-linking and the formation of immun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::035ff88c461379a8814ea6ee432cd191
https://doi.org/10.1158/1535-7163.mct-20-0269
https://doi.org/10.1158/1535-7163.mct-20-0269
Autor:
Jakob C. Stüber, Karin F. Rechberger, Saša M. Miladinović, Thomas Pöschinger, Tamara Zimmermann, Remi Villenave, Miro J. Eigenmann, Thomas E. Kraft, Dhaval K. Shah, Hubert Kettenberger, Wolfgang F. Richter
This study explores the impact of antibody surface charge on tissue distribution into various tissues including tumor. Tumor-bearing mice were dosed intravenously with a mixture comprising three antibodies engineered to carry negative charge patches,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e366e898c5ae827d84ad0a80214d8142
https://doi.org/10.1101/2021.09.01.458024
https://doi.org/10.1101/2021.09.01.458024
Autor:
Thorsten Lehr, Christian Klein, Sylvia Herter, Tanja Fauti, Meric A. Ovacik, Miro J. Eigenmann, Marina Bacac, Tina Weinzierl, Arthur J Van De Vyver, Christian Pohl, Antje-Christine Walz
Publikováno v:
The AAPS journal. 24(1)
CD3-bispecific antibodies are a new class of immunotherapeutic drugs against cancer. The pharmacological activity of CD3-bispecifics is typically assessed through in vitro assays of cancer cell lines co-cultured with human peripheral blood mononuclea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::323ce188915baf0542b7d85dcfd00f54
https://pubmed.ncbi.nlm.nih.gov/34862519
https://pubmed.ncbi.nlm.nih.gov/34862519