Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Mirna Z. Ilic"'
Short- and long-term exposure of articular cartilage to curcumin or quercetin inhibits aggrecan loss
Publikováno v:
The Journal of Nutritional Biochemistry. 23:106-112
The aim of this study was to determine if curcumin and quercetin inhibit induced aggrecan loss from bovine articular cartilage explants given that these polyphenols have been shown to suppress the expression of matrix-degrading enzymes. The kinetics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e75437b81c3a5692756b6825b2ff48bb
https://doi.org/10.1016/j.jnutbio.2010.11.004
https://doi.org/10.1016/j.jnutbio.2010.11.004
Autor:
Jill Cook, Mirna Z. Ilic, Tom Samiric, Christopher J. Handley, Julian A. Feller, John Parkinson
Publikováno v:
Arthritis & Rheumatism. 62:3028-3035
Objective. To determine differences in the metabolism of proteoglycans and the gene expression of proteinases and their inhibitors between patellar tendons exhibiting chronic overuse tendinopathy and normal patellar tendons in humans. Methods. Rates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69116a9750051dee67720a1c283d4dba
https://doi.org/10.1002/art.27587
https://doi.org/10.1002/art.27587
Autor:
Øystein Lian, Roald Bahr, Vincent Duronio, John Parkinson, Clive R. Roberts, Christopher J. Handley, Jillianne Leigh Cook, David A. Hart, Alex Scott, Karim M. Khan, Tom Samiric, Mirna Z. Ilic
Publikováno v:
Scandinavian Journal of Medicine & Science in Sports. 18:427-435
Expansion of the extracellular matrix is a prominent but poorly characterized feature of tendinosis. The present study aimed to characterize the extent and distribution of the large aggregating proteoglycan versican in patients with patellar tendinos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20ff23775c59666ca960da18e2e3800f
https://doi.org/10.1111/j.1600-0838.2007.00735.x
https://doi.org/10.1111/j.1600-0838.2007.00735.x
Publikováno v:
European Journal of Biochemistry. 271:3612-3620
This work investigated the kinetics of catabolism and the catabolic fate of the newly synthesized (35)S-labelled proteoglycans present in explant cultures of tendon. Tissue from the proximal region of bovine deep flexor tendon was incubated with [(35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37a9f49c26eef0c3cecc9caf8831c033
https://doi.org/10.1111/j.0014-2956.2004.04307.x
https://doi.org/10.1111/j.0014-2956.2004.04307.x
Publikováno v:
Matrix Biology. 23:127-140
Tendons are collagenous tissues made of mainly Type I collagen and it has been shown that the major proteoglycans of tendons are decorin and versican. Little is still known about the catabolism of these proteoglycans in tendon. Therefore, the aim of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05d62d2862457eb60cb636a6f17a7971
https://doi.org/10.1016/j.matbio.2004.03.004
https://doi.org/10.1016/j.matbio.2004.03.004
Publikováno v:
Osteoarthritis and Cartilage. 11:613-622
Objective : To investigate the effect of long-term exposure to glucosamine or mannosamine on the catabolism of aggrecan by explant cultures of bovine articular cartilage maintained in the presence of retinoic acid. Design : The kinetics of loss of 35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5b9867ef4968feb4e9fa4b02df67fcb
https://doi.org/10.1016/s1063-4584(03)00092-x
https://doi.org/10.1016/s1063-4584(03)00092-x
Autor:
Gavin C. Jones, Christopher J. Handley, C. Graham Knight, Anthony J. Day, Mireille Vankemmelbeke, Cyprianne Fowles, David J. Buttle, Mirna Z. Ilic, John S. Mort
Publikováno v:
European Journal of Biochemistry. 270:2394-2403
Three mammalian ADAMTS enzymes, ADAMTS-1, -4 and -5, are known to cleave aggrecan at certain glutamyl bonds and are considered to be largely responsible for cartilage aggrecan catabolism observed during the development of arthritis. We have previousl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0219665cd02b67725f6804a955378cfa
https://doi.org/10.1046/j.1432-1033.2003.03607.x
https://doi.org/10.1046/j.1432-1033.2003.03607.x
Autor:
Christopher J. Handley, David J. Buttle, Clair Adcocks, H. Clem Robinson, Mirna Z. Ilic, Meng Tuck Mok
Publikováno v:
Matrix Biology. 20:543-553
Bovine aggrecan was digested with bovine cathepsin D at pH 5.2 under conditions of partial digestion and the resulting aggrecan core protein fragments were separated by electrophoresis on gradient polyacrylamide gels. The fragments were characterized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b4945a89c1e9c7239cf3774a67af6c0
https://doi.org/10.1016/s0945-053x(01)00168-8
https://doi.org/10.1016/s0945-053x(01)00168-8
Autor:
Mireille Vankemmelbeke, Melody Clark, Changlu Liu, David J. Buttle, Gregory S. Kelner, David Burnett, Ingunn Holen, Mirna Z. Ilic, Richard A. Maki, Anthony G. Wilson, Christopher J. Handley
Publikováno v:
European Journal of Biochemistry. 268:1259-1268
ADAMTS proteinases, belonging to the adamalysin subfamily of metalloproteinases, have been implicated in a variety of cellular events such as morphogenesis, cell migration, angiogenesis, ovulation and extracellular matrix breakdown. Aggrecanase-1 (AD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f4970c5cdcc9259ecf1a089d652447e
https://doi.org/10.1046/j.1432-1327.2001.01990.x
https://doi.org/10.1046/j.1432-1327.2001.01990.x
Publikováno v:
Arthritis & Rheumatism. 43:2211-2218
Objective. The catabolism of aggrecan and loss of aggrecan fragments from articular cartilage is a key event in the pathogenesis of arthritic diseases such as osteoarthritis. The catabolism of aggrecan is mediated by the specific proteolytic activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3cffed0b3591061ecc8bb9af9ab80851
https://doi.org/10.1002/1529-0131(200010)43:10<2211::aid-anr8>3.0.co
https://doi.org/10.1002/1529-0131(200010)43:10<2211::aid-anr8>3.0.co